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Ezetimibe + Simvastatin

Uses of Ezetimibe + Simvastatin

  • Ezetimibe + Simvastatin is primarily used to manage high cholesterol levels in patients with hyperlipidemia (high levels of fats in the blood). It belongs to a group of medicines known as lipid-regulating medicines.

  • It is also used in patients with homozygous familial hypercholesterolemia and homozygous sitosterolemia, both are rare genetic disorders causing very high cholesterol levels.

Side effects of Ezetimibe + Simvastatin

  • Headache

  • Increased liver enzymes

  • Muscle pain

  • Upper respiratory infection

  • Diarrhoea

  • Abdominal pain

How Ezetimibe + Simvastatin works

  • Ezetimibe + Simvastatin is a cholesterol-lowering combination.

  • Ezetimibe works by blocking the absorption of cholesterol from the food you eat in your intestine.

  • Simvastatin is an enzyme inhibitor. It works by blocking an enzyme called HMG-CoA reductase in your liver that is responsible for making cholesterol.

Certified content

Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Ezetimibe + Simvastatin is available for oral use in the form of tablets.

  • These tablets are to be taken by mouth.

Age and Dose Restrictions

  • This medicine is meant for adults. It is generally prescribed for individuals who are 18 years of age and older.

Contraindications

  • Ezetimibe + Simvastatin is contraindicated in patients with active liver disease or unexplained persistent elevations of liver enzymes.

  • It is also contraindicated in patients who are hypersensitive to any component of this medication.

Other Medications to Avoid

  • This combination may interact with cyclosporine (an immunosuppressant), danazol (a synthetic steroid), amiodarone, verapamil, diltiazem (heart rate and rhythm regulators), niacin (a form of vitamin B3), fenofibrate (a lipid-lowering medication), colchicine (used to treat gout attacks).

Overdose and Missed Dose

  • An overdose of Ezetimibe + Simvastatin may lead to increased side effects such as muscle pain or weakness, which could be signs of serious conditions like rhabdomyolysis. Immediate medical attention is required in cases of overdose.

  • If you miss a dose of this medication, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not take two doses at the same time or extra doses.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • If experiencing mild gastrointestinal upset from Ezetimibe + Simvastatin, consider taking your dose with food or at bedtime to reduce discomfort.

  • Stay well hydrated by drinking plenty of water which might help alleviate some minor side effects like headaches or dizziness.

Use in Driving and Operating Machinery

  • Ezetimibe + Simvastatin may cause dizziness or sleepiness in some individuals. It is advised to avoid driving or operating heavy machinery if you experience these side effects.

Use in Pregnancy and Lactation

  • Ezetimibe + Simvastatin is not recommended during pregnancy or while breastfeeding. It could potentially harm the fetus or a nursing baby as cholesterol is crucial for fetal development. Always consult your doctor before using this medication if you are pregnant or planning to become pregnant.

Caution in Other Conditions

  • Patients with a history of liver disease need to use Ezetimibe + Simvastatin with caution and under close monitoring.

  • Individuals with kidney issues should discuss their condition with their doctor, as dosage adjustments might be necessary.

Special Dietary and Lifestyle Recommendations

  • Maintain a low-cholesterol and low-fat diet to help manage cholesterol levels effectively while using Ezetimibe + Simvastatin.

  • Incorporate foods high in fibre such as fruits, vegetables, and whole grains which can help reduce the absorption of cholesterol.

  • Regular physical activity is recommended. Aim for at least 150 minutes of moderate-intensity aerobic exercise per week, such as brisk walking or cycling.

  • Avoid consuming grapefruit or grapefruit juice as it can interfere with the effectiveness of Ezetimibe + Simvastatin and increase the risk of side effects.

Frequently asked questions

No, Ezetimibe + Simvastatin is not a steroid. It is a combination medication used to manage high cholesterol levels in the body.

No, Ezetimibe + Simvastatin does not typically affect sleep. However, if you experience sleep disturbances while taking this medicine, consult your doctor for advice.

No, there is no scientific evidence suggesting that Ezetimibe + Simvastatin affects fertility. However, if you are planning pregnancy, discuss it with your doctor as this medication should not be taken during pregnancy.

Yes, a diet low in fats and cholesterol should be maintained when taking Ezetimibe + Simvastatin. Also, consumption of large amounts of grapefruit or grapefruit juice should be avoided as it can increase the risk of side effects.

Yes, it is usually safe to take Ezetimibe + Simvastatin long-term as prescribed by your doctor to manage high cholesterol levels. Do not stop taking the medication without consulting your doctor as this could cause your cholesterol levels to increase again.

It may take up to 4 weeks to see the full effect of Ezetimibe + Simvastatin. Continue taking the medication as directed by your doctor even if you do not notice any immediate changes.

Antacids can reduce the absorption of Ezetimibe, one of the ingredients in this combination. Therefore, if you need to take an antacid, do so at least 2 hours before or 4 hours after taking your Ezetimibe + Simvastatin dose.

Terms & Conditions


Available medicines for EZETIMIBE + SIMVASTATIN
Starstat-ez 20/10 MG Tablet 10
Starstat-ez 20/10 MG Tablet 10
Lupin Ltd
Pack of 10 Units
₹79.80
MRP ₹97.32
18.00% OFF
Arstatin-ez 10/10 MG Tablet 10
Arstatin-ez 10/10 MG Tablet 10
Aretaeus Pharmaceuticals
Pack of 10 Units
₹114.80
MRP ₹140.00
18.00% OFF
Simvotin Ez 20/10 MG Tablet 10
Simvotin Ez 20/10 MG Tablet 10
Ranbaxy Laboratories Ltd
Pack of 10 Units
₹210.74
MRP ₹257.00
18.00% OFF
Zostamax 10/10 MG Tablet 10
Zostamax 10/10 MG Tablet 10
Usv Pvt Ltd
Pack of 10 Units
₹68.69
MRP ₹83.77
18.00% OFF
Starstat-ez 10/10 MG Tablet 10
Starstat-ez 10/10 MG Tablet 10
Lupin Ltd
Pack of 10 Units
₹57.30
MRP ₹69.88
18.00% OFF
Simvotin Ez 10/10 MG Tablet 10
Simvotin Ez 10/10 MG Tablet 10
Ranbaxy Laboratories Ltd
Pack of 10 Units
₹103.95
MRP ₹126.77
18.00% OFF
Arstatin Ez 10/10 MG Tablet 10
Arstatin Ez 10/10 MG Tablet 10
Aretaeus Pharmaceuticals
Pack of 10 Units
₹114.80
MRP ₹140.00
18.00% OFF
Simcard Ez Tablet 10
Simcard Ez Tablet 10
Cipla Ltd.
Pack of 10 Units
₹49.20
MRP ₹60.00
18.00% OFF

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