Ezetimibe + Simvastatin

Dosage Forms Available

• Ezetimibe + Simvastatin is available for oral use in the form of tablets.

• These tablets are to be taken by mouth.

Age and Dose Restrictions

• This medicine is meant for adults. It is generally prescribed for individuals who are 18 years of age and older.

Contraindications

• Ezetimibe + Simvastatin is contraindicated in patients with active liver disease or unexplained persistent elevations of liver enzymes.

• It is also contraindicated in patients who are hypersensitive to any component of this medication.

Other Medications to Avoid

• This combination may interact with cyclosporine (an immunosuppressant), danazol (a synthetic steroid), amiodarone, verapamil, diltiazem (heart rate and rhythm regulators), niacin (a form of vitamin B3), fenofibrate (a lipid-lowering medication), colchicine (used to treat gout attacks).

Overdose and Missed Dose

• An overdose of Ezetimibe + Simvastatin may lead to increased side effects such as muscle pain or weakness, which could be signs of serious conditions like rhabdomyolysis. Immediate medical attention is required in cases of overdose.

• If you miss a dose of this medication, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not take two doses at the same time or extra doses.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• If experiencing mild gastrointestinal upset from Ezetimibe + Simvastatin, consider taking your dose with food or at bedtime to reduce discomfort.

• Stay well hydrated by drinking plenty of water which might help alleviate some minor side effects like headaches or dizziness.

Use in Driving and Operating Machinery

• Ezetimibe + Simvastatin may cause dizziness or sleepiness in some individuals. It is advised to avoid driving or operating heavy machinery if you experience these side effects.

Use in Pregnancy and Lactation

• Ezetimibe + Simvastatin is not recommended during pregnancy or while breastfeeding. It could potentially harm the fetus or a nursing baby as cholesterol is crucial for fetal development. Always consult your doctor before using this medication if you are pregnant or planning to become pregnant.

Caution in Other Conditions

• Patients with a history of liver disease need to use Ezetimibe + Simvastatin with caution and under close monitoring.

• Individuals with kidney issues should discuss their condition with their doctor, as dosage adjustments might be necessary.

Special Dietary and Lifestyle Recommendations

• Maintain a low-cholesterol and low-fat diet to help manage cholesterol levels effectively while using Ezetimibe + Simvastatin.

• Incorporate foods high in fibre such as fruits, vegetables, and whole grains which can help reduce the absorption of cholesterol.

• Regular physical activity is recommended. Aim for at least 150 minutes of moderate-intensity aerobic exercise per week, such as brisk walking or cycling.

• Avoid consuming grapefruit or grapefruit juice as it can interfere with the effectiveness of Ezetimibe + Simvastatin and increase the risk of side effects.