Fludarabine

Dosage Forms Available

• Bosutinib is available in the tablet form to be taken orally.

Age and Dose Restrictions

• Bosutinib is meant for use by adults. It is not recommended for paediatric patients as its safety and effectiveness have not been established in this age group.

Contraindications

• Bosutinib is contraindicated in known hypersensitivity and liver impairment.

Other Medications to Avoid

• Bosutinib may interact with blood pressure-lowering medicines (such as amlodipine, lisinopril), anticoagulants (such as warfarin, dabigatran), medications affecting liver enzymes (such as ketoconazole, rifampin), and other anti-cancer drugs (such as imatinib, nilotinib). It can also interact with medications that affect gastrointestinal pH (such as omeprazole, ranitidine).

Overdose and Missed Dose

• In cases of overdose with Bosutinib, the individual should be given appropriate supportive treatment. There is no specific antidote available for an overdose of Bosutinib.
• If a dose of Bosutinib is missed and it is more than 12 hours until the next dose, skip the missed dose and continue with the next scheduled dose. Do not double the next dose to make up for the missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• To manage nausea, taking Bosutinib with food might help.
• In case of mild diarrhoea, consider staying hydrated by drinking plenty of water.

Use in Driving and Operating Machinery

• Bosutinib may cause dizziness or fatigue. If you experience these symptoms, avoid driving or operating heavy machinery.

Use in Pregnancy and Lactation

• Bosutinib may cause harm to a foetus; therefore, it is not recommended during pregnancy.
• It is advised that breastfeeding should be discontinued during treatment with Bosutinib and for at least two weeks after the final dose.
• Always consult your doctor before using Bosutinib if you are pregnant or breastfeeding.

Caution in Other Conditions

• Caution is advised when using Bosutinib in patients with liver or kidney impairment. Dose adjustments may be necessary.
• Patients with a history of cardiac conditions should be closely monitored due to the risk of cardiac toxicity.

Special Dietary and Lifestyle Recommendations

• Ensure sufficient hydration to help manage potential side effects like nausea and diarrhoea.
• Maintain a balanced diet while undergoing treatment with Bosutinib. Include foods that are easy on the stomach to help manage gastrointestinal side effects such as nausea and abdominal pain.
• Given the risk of fatigue while on Bosutinib, incorporate light to moderate physical activity as tolerated, which can enhance overall well-being. Adjust activities based on personal energy levels.
• It might be beneficial to avoid excessive consumption of grapefruit or grapefruit juice, which can alter the concentration of Bosutinib in your blood, which may lead to increased side effects.