Fluticasone
Uses of Fluticasone
Fluticasone is primarily used to manage allergic rhinitis, asthma, nasal polyps, and skin conditions. It is a synthetic corticosteroid medication.
Other uses include relieving symptoms of hay fever and other respiratory allergies, such as sneezing, runny nose, itchy nose and eyes, and sinus congestion. It is also used to prevent asthma symptoms such as wheezing and shortness of breath.
Side effects of Fluticasone
Headache
Nausea
Nosebleeds
Sore throat
Nasal burning and irritation
How Fluticasone works
Fluticasone is a potent synthetic corticosteroid.
It works by binding to glucocorticoid receptors in the cells, reducing the production of inflammatory chemicals like cytokines and prostaglandins. This action decreases inflammation, swelling, and mucus production in the airways, making it easier to breathe. It is commonly used in treating conditions like asthma and allergic rhinitis.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Fluticasone is available in various forms for different routes of administration.
It can be administered nasally in the form of a spray to manage conditions like allergic rhinitis and nasal polyps.
Fluticasone is also available as an inhaler for delivering the medication directly to the lungs, this formulation is mainly used for managing symptoms of asthma.
For managing skin conditions, it is available as topical creams, ointments, and lotions.
Age and Dose Restrictions
Fluticasone is suitable for both adults and children. However, for children, especially when used long-term, it necessitates regular monitoring as it may slow growth.
Contraindications
The use of Fluticasone is contraindicated in individuals with untreated fungal, bacterial, or viral infections affecting the nose, mouth, or lungs.
Other Medications to Avoid
Fluticasone can interact with CYP3A4 inhibitors (e.g., Ketoconazole, Ritonavir), increasing fluticasone levels and the risk of side effects like adrenal suppression. It also interacts with other corticosteroids (e.g., Prednisone), raising the risk of systemic side effects. Additionally, beta-blockers (e.g., Propranolol) may reduce its effectiveness in treating respiratory conditions, while antifungal and antiviral medications (e.g., Itraconazole, Saquinavir) can elevate fluticasone levels, leading to potential side effects.
Overdose and Missed Dose
Overdosing on Fluticasone may lead to severe side effects such as nosebleeds, cataracts, glaucoma, and impaired wound healing. If you observe these symptoms, inform your doctor immediately.
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening symptoms, please consult your doctor.
Drinking plenty of fluids can help manage some of the side effects like dry mouth.
Avoiding contact with allergens and irritants can help manage skin irritation caused by topical Fluticasone.
Use in Driving and Operating Machinery
Fluticasone does not usually affect your ability to drive or operate heavy machinery. However, if you experience dizziness or drowsiness after using Fluticasone, avoid driving or operating heavy machinery.
Use in Pregnancy and Lactation
The use of Fluticasone during pregnancy and breastfeeding should be decided only after consulting with your doctor.
Caution in Other Conditions
Patients with a history of nosebleeds, nasal ulcers, or nasal surgery should exercise caution while using Fluticasone nasal spray.
Regular eye exams are advised for patients with conditions like glaucoma and cataracts while being managed with inhaled Fluticasone.
Special Dietary and Lifestyle Recommendations
Maintaining a low-sodium diet may help manage high blood pressure which is a risk factor for conditions like asthma.
Avoiding exposure to allergens can help manage the symptoms of allergic rhinitis.
Regular gentle exercise can help improve lung function in individuals with asthma.
Maintaining good hygiene can prevent skin infections that exacerbate conditions like eczema and psoriasis.
Frequently asked questions
Is Fluticasone used for skin conditions?
Yes, topical forms of Fluticasone are used to manage symptoms of inflammatory skin conditions like eczema and psoriasis. This medicine helps reduce redness, itching, and rash associated with these conditions.
How long does it take for Fluticasone to show effects?
Fluticasone starts working within a day of starting the medication. However, maximum benefits might take a week or more to be noticed. Remember, it is important to use Fluticasone regularly as directed by your doctor for it to effectively control your symptoms.
Can I take Fluticasone if I have an infection?
If you have untreated bacterial, fungal, or viral infections affecting your nose, mouth, or lungs, you should not use Fluticasone until the infection has cleared. It can potentially worsen existing infections.
Can Fluticasone cause growth issues in children?
Long-term use of Fluticasone may slow down growth in children. Regular monitoring is necessary if this medication is prescribed for paediatric patients.
Can I use other medications while using Fluticasone?
Certain medications, such as Ritonavir and other CYP3A4 inhibitors, can interact with Fluticasone and cause adverse effects like Cushing's syndrome and adrenal suppression at normal doses of Fluticasone. Always inform your doctor about all medicines you are taking before starting Fluticasone.
What precautions should I take while using a Fluticasone inhaler?
Inhaled Fluticasone could potentially worsen eye conditions such as glaucoma and cataracts. If you are using an inhaler form of the medicine and have these conditions, it is recommended to have regular eye check-ups during treatment.
How should Fluticasone nasal spray be used?
After shaking the nasal spray well, blow your nose gently. Place the applicator tip into one nostril while holding the other nostril closed, then spray while breathing in through the nose. Repeat in the other nostril. Avoid spraying it into your eyes or mouth.
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