Gemfibrozil
Uses of Gemfibrozil
The main use of Gemfibrozil is managing high levels of triglycerides and cholesterol in the blood, which are risk factors for heart disease and stroke. This medicine belongs to the fibrate class of medications.
Side effects of Gemfibrozil
Abdominal pain
Diarrhoea
Nausea
Vomiting
Muscle pain and weakness
How Gemfibrozil works
Gemfibrozil is a type of medication known as a fibrate.
It primarily works by activating a specific protein in the body called peroxisome proliferator-activated receptor-alpha (PPAR-α). This protein helps to control various genes that are involved in the metabolism of fats, specifically triglycerides and cholesterol. Additionally, Gemfibrozil boosts the activity of an enzyme called lipoprotein lipase.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Gemfibrozil is available in two forms, tablets and capsules, for oral administration.
Age and Dose Restrictions
This medicine is prescribed for adults and children who are above the age of 18 years.
Always consult a healthcare provider before using Gemfibrozil in pediatric patients.
Contraindications
This medicine is contraindicated in individuals who have had an allergic reaction to the active ingredient or any of the other components of the medication.
It is also contraindicated in those with severe liver or kidney dysfunction and pre-existing gallbladder disease.
Other Medications to Avoid
Gemfibrozil may interact with statins (such as rosuvastatin, atorvastatin), anticoagulants (like warfarin), hypoglycaemic agents (for example and glipizide) and bile acid sequestrants (such as cholestyramine).
Overdose and Missed Dose
Consuming more than the advised dose can lead to an overdose. In case of an overdose, seek immediate medical attention.
If you miss a dose, take it as soon as you remember. However, if it is nearly time for the next dose, skip the missed dose. Do not double up on doses to make up for a missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any symptoms, please consult your doctor.
Avoiding fatty foods might lessen gastrointestinal disturbances such as stomach pain or nausea.
Taking the medicine with meals might ease some side effects like nausea or stomach upset.
Use in Driving and Operating Machinery
This medicine can cause side effects like dizziness and blurred vision which can affect your ability to drive or operate machinery. It is advisable not to drive or operate machinery until you know how Gemfibrozil affects you.
Use in Pregnancy and Lactation
The safety of Gemfibrozil during pregnancy and breastfeeding has not been fully established. Therefore, it should be used during these periods only if the potential benefit justifies the potential risk. Always consult your doctor before taking this medicine during pregnancy or lactation.
Caution in Other Conditions
Patients with renal or hepatic impairment should exercise caution when using Gemfibrozil. Regular monitoring of kidney and liver function is recommended in these patients.
Special Dietary and Lifestyle Recommendations
If you are taking Gemfibrozil, it is recommended to adopt a low-fat, low-cholesterol diet to help manage your lipid levels.
Maintain a healthy weight by balancing calorie intake with physical activity. Even a modest weight loss can help lower triglyceride and cholesterol levels.
Frequently asked questions
Is Gemfibrozil a steroid?
No, Gemfibrozil is not a steroid. It is a type of medicine known as fibrate, which is used to manage high levels of cholesterol and triglycerides in the blood.
Does taking Gemfibrozil affect sleep in any way?
Gemfibrozil, a medication used to lower cholesterol and triglycerides, generally doesn't list sleep disturbances as a common side effect. If you're having trouble sleeping and suspect it might be related to the medication, it's a good idea to consult your doctor.
Can Gemfibrozil affect fertility in men or women?
Gemfibrozil is not commonly associated with affecting fertility in men or women. If you have concerns, consult your doctor for personalised advice.
Is it safe to take Gemfibrozil every day?
Yes, it is safe to take Gemfibrozil every day as long as it is prescribed by your doctor.
How quickly does Gemfibrozil start working?
Gemfibrozil usually begins to work within a few days of taking it regularly. However, it may take a few weeks for you to see significant improvements in your blood lipid levels.
Can Gemfibrozil cause an allergic reaction?
Yes, some people may experience an allergic reaction to Gemfibrozil. Symptoms can include difficulty breathing and swelling of the face, lips, tongue, or throat. If you experience these symptoms, it is necessary to seek immediate medical attention.
Will Gemfibrozil affect my mood?
Gemfibrozil is primarily used to lower cholesterol and triglycerides. While mood changes are not common side effects, some people may experience them. If you notice any changes in your mood or other unusual symptoms, it's a good idea to consult your doctor.
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