Glibenclamide + Metformin

Dosage Forms Available

• Glibenclamide + Metformin is available in the form of tablets for oral administration.

Age and Dose Restrictions

• This medicine is intended for use in adults and children above the age of 10 years.

Contraindications

• This combination is contraindicated in patients with type 1 diabetes. It is also not advisable for those with severe kidney disease, liver disease, and metabolic acidosis. Patients known to have an allergy to either Glibenclamide or Metformin should avoid this medicine.

Other Medications to Avoid

• Glibenclamide + Metformin may interact with diuretics (such as furosemide and torsemide), steroids (like prednisone, dexamethasone), seizure medicines (like phenytoin, phenobarbital), thyroid medicines (like levothyroxine, liothyronine), certain antibiotics (like levofloxacin, ofloxacin), antifungals (such as fluconazole, itraconazole), calcium channel blockers (like nifedipine, amlodipine), and beta-blockers (like propranolol, atenolol).

Overdose and Missed Dose

• Overdosing on Glibenclamide + Metformin can result in lactic acidosis, a severe condition that requires immediate medical attention.

• If one forgets to take a dose, it should be taken as soon as it is remembered unless it is nearly time for the next dose. In that case, the missed dose should be skipped, and the regular dosing schedule should continue.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve after discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• If you experience stomach upset or nausea, taking this medication with meals can help.

• Consult your doctor if diarrhoea persists for a prolonged period.

• Drinking plenty of fluids throughout the day can help manage dizziness and weakness.

Use in Driving and Operating Machinery

• This medicine may cause dizziness or weakness, which can affect the ability to drive or operate machinery safely. Caution is advised when performing such tasks.

Use in Pregnancy and Lactation

• This combination medicine should be avoided during pregnancy and breastfeeding unless recommended by a doctor.

Caution in Other Conditions

• Caution should be exercised when using Glibenclamide + Metformin in patients with kidney or liver conditions.

• Elderly patients may also need to exercise caution due to increased sensitivity to the medication's side effects.

Special Dietary and Lifestyle Recommendations

• Regular monitoring of blood glucose levels is crucial for tracking the effectiveness of the treatment plan.