Glibenclamide + Metformin + Rosiglitazone
Uses of Glibenclamide + Metformin + Rosiglitazone
Glibenclamide + Metformin + Rosiglitazone is primarily used to manage type 2 diabetes mellitus. This combination belongs to the class of antidiabetic medications.
It is prescribed for adult patients whose blood sugar levels are not adequately controlled by diet, exercise, and dual therapy with metformin plus either glibenclamide or rosiglitazone.
Side effects of Glibenclamide + Metformin + Rosiglitazone
Upper respiratory tract infection
Injury
Headache
Back pain
Hyperglycaemia
How Glibenclamide + Metformin + Rosiglitazone works
Glibenclamide + Metformin + Rosiglitazone is a combination medicine used to manage type 2 diabetes mellitus.
Glibenclamide is a sulfonylurea. It stimulates the pancreas to produce more insulin, which helps to move glucose from the blood into cells, thereby reducing blood sugar levels.
Metformin is a biguanide. It reduces the amount of glucose produced by the liver, increases the sensitivity of cells to insulin, and delays glucose absorption from the intestines. This leads to a decrease in blood sugar levels.
Rosiglitazone is a thiazolidinedione. It works by making fat, muscle, and liver cells more sensitive to insulin, enabling these cells to absorb more glucose from the blood and lower blood sugar levels.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Glibenclamide + Metformin + Rosiglitazone is available as an oral medication in tablet form.
Age and Dose Restrictions
This medicine is intended for use in adults only.
Contraindications
Glibenclamide + Metformin + Rosiglitazone is contraindicated in patients with Type 1 diabetes or diabetic ketoacidosis, severe renal impairment or renal disease, and acute or chronic metabolic acidosis. It is also contraindicated in individuals with known hypersensitivity to any of the components and in those with congestive heart failure of NYHA Class III or IV.
Other Medications to Avoid
This combination may interact with other anti-diabetic agents (such as insulin), NSAIDs (like ibuprofen), sulfonylureas (such as glimepiride), thiazides (including hydrochlorothiazide), corticosteroids (such as prednisone), phenothiazines (like chlorpromazine), thyroid products (such as levothyroxine), oral contraceptives (like ethinylestradiol), and calcium channel blockers (such as amlodipine).
Overdose and Missed Dose
An overdose of Glibenclamide + Metformin + Rosiglitazone can lead to severe hypoglycemia, lactic acidosis, and potential heart failure. Immediate medical attention is advised.
If you miss a dose of this medicine, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
If experiencing mild digestive upset, consider taking the medication with food.
To manage mild headaches, ensure adequate hydration and take the medicine after a light meal.
Use in Driving and Operating Machinery
This medication may impair your ability to drive or operate machinery. Do not drive or engage in activities requiring alertness if you feel dizzy or experience visual disturbances.
Use in Pregnancy and Lactation
Glibenclamide + Metformin + Rosiglitazone is not recommended during pregnancy and lactation. The potential risks should be weighed against the benefits in consultation with your doctor.
Caution in Other Conditions
Patients with liver disease should use Glibenclamide + Metformin + Rosiglitazone with caution. Regular monitoring of liver function tests is advisable.
It should be used cautiously in patients with a history of heart disease.
Special Dietary and Lifestyle Recommendations
Follow a balanced diet rich in whole grains, vegetables, and lean proteins. Avoid excessive carbohydrates and sugar.
Maintain regular physical activity to help manage blood sugar levels—aim for at least 150 minutes of moderate exercise per week.
Monitor blood glucose regularly to assess the effectiveness of the medication and dietary adjustments.
Frequently asked questions
Is Glibenclamide + Metformin + Rosiglitazone a steroid?
No, Glibenclamide + Metformin + Rosiglitazone is not a steroid. It is a combination medication used for the management of type 2 diabetes.
Does Glibenclamide + Metformin + Rosiglitazone have any effect on sleep?
There are no direct effects of Glibenclamide + Metformin + Rosiglitazone on sleep mentioned in the sources. However, uncontrolled blood sugar levels can impact sleep patterns.
Will Glibenclamide + Metformin + Rosiglitazone affect fertility?
Rosiglitazone, an active ingredient in this combination, may result in ovulation in premenopausal anovulatory women, potentially affecting fertility.
Are there any particular diet restrictions while taking Glibenclamide + Metformin + Rosiglitazone?
The medication should be taken as an adjunct to diet and exercise to manage blood sugar levels. No specific food restrictions are mentioned, but a balanced, diabetic-friendly diet is recommended.
Is it safe to take Glibenclamide + Metformin + Rosiglitazone daily?
Yes, it is usually safe to take Glibenclamide + Metformin + Rosiglitazone daily, as per your doctor's recommendation.
How much time does Glibenclamide + Metformin + Rosiglitazone take to work?
The time taken for this combination to work can vary. Peak plasma concentrations for the individual components occur between 1 to 4 hours after ingestion.
What is the best time to take Glibenclamide + Metformin + Rosiglitazone?
This medication is typically taken with meals, as directed by your doctor.
Glibenclamide + Metformin + Rosiglitazone in other salts
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