Glibenclamide + Metformin + Rosiglitazone

Dosage Forms Available

• Glibenclamide + Metformin + Rosiglitazone is available as an oral medication in tablet form.

Age and Dose Restrictions

• This medicine is intended for use in adults only.

Contraindications

• Glibenclamide + Metformin + Rosiglitazone is contraindicated in patients with Type 1 diabetes or diabetic ketoacidosis, severe renal impairment or renal disease, and acute or chronic metabolic acidosis. It is also contraindicated in individuals with known hypersensitivity to any of the components and in those with congestive heart failure of NYHA Class III or IV.

Other Medications to Avoid

• This combination may interact with other anti-diabetic agents (such as insulin), NSAIDs (like ibuprofen), sulfonylureas (such as glimepiride), thiazides (including hydrochlorothiazide), corticosteroids (such as prednisone), phenothiazines (like chlorpromazine), thyroid products (such as levothyroxine), oral contraceptives (like ethinylestradiol), and calcium channel blockers (such as amlodipine).

Overdose and Missed Dose

• An overdose of Glibenclamide + Metformin + Rosiglitazone can lead to severe hypoglycemia, lactic acidosis, and potential heart failure. Immediate medical attention is advised.

• If you miss a dose of this medicine, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• If experiencing mild digestive upset, consider taking the medication with food.

• To manage mild headaches, ensure adequate hydration and take the medicine after a light meal.

Use in Driving and Operating Machinery

• This medication may impair your ability to drive or operate machinery. Do not drive or engage in activities requiring alertness if you feel dizzy or experience visual disturbances.

Use in Pregnancy and Lactation

• Glibenclamide + Metformin + Rosiglitazone is not recommended during pregnancy and lactation. The potential risks should be weighed against the benefits in consultation with your doctor.

Caution in Other Conditions

• Patients with liver disease should use Glibenclamide + Metformin + Rosiglitazone with caution. Regular monitoring of liver function tests is advisable.

• It should be used cautiously in patients with a history of heart disease.

Special Dietary and Lifestyle Recommendations

• Follow a balanced diet rich in whole grains, vegetables, and lean proteins. Avoid excessive carbohydrates and sugar.

• Maintain regular physical activity to help manage blood sugar levels—aim for at least 150 minutes of moderate exercise per week.

• Monitor blood glucose regularly to assess the effectiveness of the medication and dietary adjustments.