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Glimepiride + Metformin + Rosiglitazone

Uses of Glimepiride + Metformin + Rosiglitazone

  • The primary use of Glimepiride + Metformin + Rosiglitazone is for the management of type 2 diabetes mellitus. This medicine belongs to the antidiabetic group of medicines.

  • In addition to managing high blood sugar levels in people with type 2 diabetes, it can be used when diet and exercise alone doesnot provide adequate glycaemic control.

Side effects of Glimepiride + Metformin + Rosiglitazone

  • Hypoglycaemia

  • Nausea

  • Diarrhoea

  • Increased appetite

  • Weight gain

How Glimepiride + Metformin + Rosiglitazone works

  • Glimepiride + Metformin + Rosiglitazone is a combination of oral antidiabetic medications.

  • Glimepiride is a sulfonylurea type of medicine. It stimulates the beta cells in the pancreas to produce more insulin, which helps to lower blood glucose levels.

  • Metformin belongs to the biguanide class of medicines. It reduces the amount of glucose produced by the liver and enhances insulin sensitivity, thereby helping your body use the insulin it produces more effectively.

  • Rosiglitazone is a thiazolidinedione. It acts on PPAR-gamma nuclear receptors to regulate genes involved in glucose and lipid metabolism, which improves insulin sensitivity in muscle and adipose tissues.

Certified content

Written By

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Dr. Michelle FrankMedical Content Writer| 8 years

Doctor of Medicine

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Glimepiride + Metformin + Rosiglitazone is available in the form of oral tablets.

Age and Dose Restrictions

  • This medication is meant for adults only. It is not recommended for children or adolescents under 18 years of age.

Contraindications

  • Patients with severe heart failure are advised against using Glimepiride + Metformin + Rosiglitazone.

  • Those with severe kidney impairment should not take this medication due to the risk of metformin accumulation.

Other Medications to Avoid

  • This combination may interact with other diabetes medications (such as insulin and sulfonylureas), cationic medicines (such as amiloride, cimetidine, digoxin and morphine), corticosteroids (like prednisone) and CYP2C8 inhibitors (like gemfibrozil).

Overdose and Missed Dose

  • Overdose of Glimepiride + Metformin + Rosiglitazone can lead to severe hypoglycaemia, lactic acidosis or other serious symptoms. If you suspect an overdose, seek medical help immediately.

  • If you miss a dose, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose to avoid doubling up.

Management of Side Effects

Most side effects can be managed by maintaining a regular eating schedule to avoid hypoglycemia, staying hydrated to help with nausea and vomiting, and monitoring blood sugar levels regularly.

  • Report any persistent or severe side effects to your doctor immediately for professional medical assistance.

Use in Driving and Operating Machinery

  • Glimepiride + Metformin + Rosiglitazone may cause dizziness or impact vision. If you experience such symptoms, avoid driving or operating heavy machinery until you know how the medication affects you.

Use in Pregnancy and Lactation

  • Use of Glimepiride + Metformin + Rosiglitazone during pregnancy is not recommended as it may harm the foetus. It is also advised to consult your doctor about its safety during breastfeeding.

Caution in Other Conditions

  • Patients with liver disease should exercise caution when taking this medicine due to the risk of metformin accumulation.

  • Individuals with a history of heart disease should also be cautious due to the potential heart failure risk associated with rosiglitazone.

Special Dietary and Lifestyle Recommendations

  • Maintain a balanced diet to help manage your blood sugar levels.

  • Regular physical activity can also help control glucose levels in your body.

  • Regular monitoring of blood glucose levels is crucial for understanding the effectiveness of this medication.

Frequently asked questions

No, Glimepiride + Metformin + Rosiglitazone is not a steroid. It is a combination of three different classes of medications, namely sulfonylurea (Glimepiride), biguanide (Metformin), and thiazolidinedione (Rosiglitazone), all used to manage type 2 diabetes mellitus.

Yes, allergic reactions can occur in some individuals. Symptoms can include rash, itching, or swelling. If you have an allergic reaction, stop using the medication and seek immediate medical attention.

Yes, weight gain can be a side effect of this medicine, particularly due to Rosiglitazone. Regular exercise and a balanced diet can help manage this side effect.

No, it is not advisable to switch your current medicine without consulting your doctor. Every medicine has its mechanism of action, side effects, and medicine interactions. Your doctor will consider all these factors before suggesting any changes to your treatment plan.

Glimepiride + Metformin + Rosiglitazone is not associated with any significant effects on mood. It is always advisable to discuss any unusual experiences with your doctor.

Yes, dizziness is a common side effect of Glimepiride + Metformin + Rosiglitazone. If you feel dizzy after taking this medication, do not drive or operate machinery and rest until you feel better.

No, it is important to continue taking Glimepiride + Metformin + Rosiglitazone as prescribed by your doctor, even if you feel better. Stopping the medication suddenly may lead to high blood sugar levels.

Terms & Conditions


Available medicines for GLIMEPIRIDE + METFORMIN + ROSIGLITAZONE
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