Glutathione
Uses of Glutathione
Glutathione primarily works as an antioxidant in the body and belongs to the group of dietary supplements.
It is also utilised for its potential benefits in enhancing skin health by reducing hyperpigmentation and wrinkles, supporting liver function by aiding detoxification processes and reducing cell damage, and boosting the immune system.
Side effects of Glutathione
Gastrointestinal discomfort
Skin irritation
Allergic reactions
Hypopigmented skin patches
Lightened hair colour
How Glutathione works
Glutathione is a naturally occurring antioxidant.
It works by neutralising harmful free radicals and reducing oxidative stress in the body. This is done by donating an electron to a free radical, thereby stabilising it and preventing it from causing further damage.
Additionally, as a detoxification agent, glutathione combines with toxins in the body making them soluble and allowing them to be excreted through urine or bile.
Its presence also supports the function of other antioxidants within the body, enhancing their effectiveness.
In its reduced form (GSH), glutathione can regenerate itself in the liver after each interaction with a free radical, ready to neutralise another.
Certified content
Written By
MSc (Applied Genetics)
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Glutathione is available in various dosage forms for different routes of administration.
It can be taken orally in the form of capsules and tablets. It can be obtained for topical use as creams and serums. This medication can also be administered as an intravenous injection under the supervision of healthcare professional.
Age and Dose Restrictions
This medicine is suitable for adults and children above 12 years of age due to the potent nature of its antioxidant properties.
Contraindications
Glutathione is contraindicated in patients who have a known allergy to any components of the medication.
Individuals with asthma should avoid inhaling glutathione, as it may exacerbate asthma symptoms.
Other Medications to Avoid
This medicine may interact with certain antipsychotics (e.g., risperidone and quetiapine) and anti-seizure medications (e.g., carbamazepine and phenytoin).
Overdose and Missed Dose
Overdose of glutathione may result in symptoms such as gastrointestinal distress or skin rashes. In such cases, consult your doctor for further advice.
If you miss a dose, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and continue with your regular schedule.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
For gastrointestinal discomfort, try taking the medicine after meals to reduce irritation.
If skin irritation occurs due to topical application, discontinue use and consult your doctor.
Use in Driving and Operating Machinery
There are no specific warnings regarding the use of Glutathione while driving or operating heavy machinery. However, if you feel dizzy or drowsy after taking this medicine, avoid these activities.
Use in Pregnancy and Lactation
The safety of Glutathione use during pregnancy and breastfeeding is not well-established. Therefore, it is suggested to consult your doctor before using this medicine during these periods.
Caution in Other Conditions
Patients with liver diseases should exercise caution when taking Glutathione as it may alter liver function tests.
Individuals with a history of kidney stones should also exercise caution as the breakdown of Glutathione can increase oxalate levels, which may contribute to stone formation.
Special Dietary and Lifestyle Recommendations
A balanced diet rich in fruits and vegetables that are high in antioxidants can supplement the action of Glutathione.
Avoid smoking and excessive alcohol consumption as these habits can increase oxidative stress, which Glutathione helps to combat.
Frequently asked questions
Is Glutathione a protein?
No, Glutathione is not a protein. It is a tripeptide, made up of three amino acids: cysteine, glycine, and glutamic acid.
Does Glutathione have any effect on mood?
There is no clear evidence to suggest that Glutathione directly affects mood. However, as an antioxidant, it can improve overall health which may indirectly influence mood.
Will Glutathione affect menstruation?
There are no studies indicating that Glutathione has any effect on menstruation.
Are there any specific foods I should avoid when taking Glutathione?
No specific foods need to be avoided when taking Glutathione. However, maintaining a balanced diet is always beneficial for overall health.
Is it safe to take Glutathione daily?
Yes, oral glutathione supplements are generally considered safe when taken in doses prescribed by your doctor for the specified duration.
How long does it take for Glutathione to start working?
The time it takes for Glutathione effects to be noticed can vary depending on the individual and the reason for use.
Is Glutathione available over the counter or do I need a prescription?
Glutathione is generally available over the counter in the form of oral supplements and topical creams. However, injectable glutathione typically requires a prescription.
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