Glycerin + Mannitol

Dosage Forms Available

• Glycerin + Mannitol is formulated as a sterile solution for intravenous infusion.

• It is administered primarily through the intravenous route directly into a vein.

Age and Dose Restrictions

• This medicine is appropriate for use in both adults and children. However, dosages may vary based on age and clinical condition.

Contraindications

• Glycerin + Mannitol is contraindicated in patients with known allergies to either glycerin or mannitol.

• It is also contraindicated for individuals with severe dehydration, hypernatremia, intracranial bleeding, severe kidney impairment or failure, and severe pulmonary oedema or heart failure.

Other Medications to Avoid

• This combination may interact with other diuretics (such as furosemide and hydrochlorothiazide), nephrotoxic medications (like gentamicin and vancomycin), medications affecting electrolyte levels (such as lithium and digoxin), and medications that can increase blood volume (like corticosteroids and hypertonic saline).

Overdose and Missed Dose

• An overdose of Glycerin + Mannitol can lead to severe dehydration, electrolyte imbalances, and kidney dysfunction. In case of overdose, immediate medical intervention is crucial to manage these potentially life-threatening conditions.

• If a dose is missed, administer it as soon as you remember. However, if it is almost time for the next scheduled dose, skip the missed dose and return to the regular dosing schedule. Do not administer two doses at once to make up for a missed dose.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• If experiencing mild dehydration symptoms such as dry mouth or thirst, increase fluid intake unless otherwise directed by a doctor.

• For headaches or mild dizziness, resting in a quiet, dark room may help alleviate these symptoms.

Use in Driving and Operating Machinery

• Glycerin + Mannitol may cause side effects such as dizziness or blurred vision which could affect your ability to drive or operate machinery safely. Avoid engaging in such activities until you know how this medication affects you.

Use in Pregnancy and Lactation

• Consult your doctor before using Glycerin + Mannitol during pregnancy or while breastfeeding. The safety of this medication for use in these conditions has not been firmly established.

Caution in Other Conditions

• Caution is advised when using Glycerin + Mannitol in patients with pre-existing kidney issues or those at risk of fluid overload.

• Patients with cardiac conditions should be monitored closely due to the potential for rapid shifts in fluid and electrolyte balance.

Special Dietary and Lifestyle Recommendations

• Maintain adequate hydration especially when undergoing treatment with Glycerin + Mannitol to help manage the risk of dehydration.

• Monitor salt intake to help manage potential electrolyte imbalances, particularly sodium and potassium levels.

• Engage in regular follow-up appointments to monitor kidney function and overall fluid status.

• Limit intake of caffeine and alcohol which can exacerbate dehydration or interact with the medicine’s diuretic effects.