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Glycerin + Mannitol

Uses of Glycerin + Mannitol

  • The primary use of Glycerin + Mannitol is for the reduction of increased intracranial pressure (ICP) and the treatment of cerebral edema. This combination belongs to a class of medicines known as osmotic diuretics.

  • Glycerin + Mannitol is also used for decreasing elevated intraocular pressure, such as before certain eye surgeries, and as an osmotic diuretic to increase urine output and reduce excess fluid or swelling in the body.

Side effects of Glycerin + Mannitol

  • Headache

  • Nausea

  • Vomiting

  • Dizziness

  • Chills

How Glycerin + Mannitol works

  • Glycerin + Mannitol is a combination predominantly used as an osmotic diuretic.

  • Mannitol functions by raising the osmotic pressure in the bloodstream. This causes fluid to move from the tissues into blood vessels, leading to an increase in the production of urine. This process helps to remove excess water from the body. In the brain, it creates an osmotic gradient that pulls fluid out, effectively reducing cerebral oedema and intracranial pressure.

  • Glycerin partners well with Mannitol due to its complementary osmotic effect. It also has its own mild diuretic properties.

Certified content

Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Glycerin + Mannitol is formulated as a sterile solution for intravenous infusion.

  • It is administered primarily through the intravenous route directly into a vein.

Age and Dose Restrictions

  • This medicine is appropriate for use in both adults and children. However, dosages may vary based on age and clinical condition.

Contraindications

  • Glycerin + Mannitol is contraindicated in patients with known allergies to either glycerin or mannitol.

  • It is also contraindicated for individuals with severe dehydration, hypernatremia, intracranial bleeding, severe kidney impairment or failure, and severe pulmonary oedema or heart failure.

Other Medications to Avoid

  • This combination may interact with other diuretics (such as furosemide and hydrochlorothiazide), nephrotoxic medications (like gentamicin and vancomycin), medications affecting electrolyte levels (such as lithium and digoxin), and medications that can increase blood volume (like corticosteroids and hypertonic saline).

Overdose and Missed Dose

  • An overdose of Glycerin + Mannitol can lead to severe dehydration, electrolyte imbalances, and kidney dysfunction. In case of overdose, immediate medical intervention is crucial to manage these potentially life-threatening conditions.

  • If a dose is missed, administer it as soon as you remember. However, if it is almost time for the next scheduled dose, skip the missed dose and return to the regular dosing schedule. Do not administer two doses at once to make up for a missed dose.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • If experiencing mild dehydration symptoms such as dry mouth or thirst, increase fluid intake unless otherwise directed by a doctor.

  • For headaches or mild dizziness, resting in a quiet, dark room may help alleviate these symptoms.

Use in Driving and Operating Machinery

  • Glycerin + Mannitol may cause side effects such as dizziness or blurred vision which could affect your ability to drive or operate machinery safely. Avoid engaging in such activities until you know how this medication affects you.

Use in Pregnancy and Lactation

  • Consult your doctor before using Glycerin + Mannitol during pregnancy or while breastfeeding. The safety of this medication for use in these conditions has not been firmly established.

Caution in Other Conditions

  • Caution is advised when using Glycerin + Mannitol in patients with pre-existing kidney issues or those at risk of fluid overload.

  • Patients with cardiac conditions should be monitored closely due to the potential for rapid shifts in fluid and electrolyte balance.

Special Dietary and Lifestyle Recommendations

  • Maintain adequate hydration especially when undergoing treatment with Glycerin + Mannitol to help manage the risk of dehydration.

  • Monitor salt intake to help manage potential electrolyte imbalances, particularly sodium and potassium levels.

  • Engage in regular follow-up appointments to monitor kidney function and overall fluid status.

  • Limit intake of caffeine and alcohol which can exacerbate dehydration or interact with the medicine’s diuretic effects.

Frequently asked questions

Glycerin + Mannitol is a combination typically used as an osmotic agent. It can be used to manage conditions like increased intracranial pressure or to promote diuresis (increased urine production) in certain medical situations. Glycerin acts as a humectant, while Mannitol helps draw water into the bloodstream, facilitating fluid balance and reducing swelling.

There are no specific food interactions with Glycerin + Mannitol. However, it is always advisable to consult your doctor about any possible interactions.

There is no evidence to suggest that Glycerin + Mannitol has any impact on mood or behaviour. If you experience any unusual changes, please consult your doctor.

Glycerin + Mannitol does not have any known addictive properties. It is intended for short-term use under the supervision of a doctor.

Alcohol may interfere with the effectiveness of many medicines. While there is no specific interaction between alcohol and Glycerin + Mannitol, it is generally advisable to avoid alcohol during treatment.

Patients receiving Glycerin + Mannitol typically require close monitoring of vital signs, fluid intake/output, and neurological status during treatment.

The ingredients in Glycerin + Mannitol do not come from animal sources. However, it is always advisable to check with your doctor or pharmacist if you have any dietary restrictions or preferences.

Terms & Conditions


Available medicines for GLYCERIN + MANNITOL
Neurotol Injection 100ml
Neurotol Injection 100ml
Venus Remedies Ltd
Pack of 100 ML
₹139.40
MRP ₹170.00
18.00% OFF
Manidrop G Infusion 100 ML
Manidrop G Infusion 100 ML
Rapid Life Drugs
Pack of 100 ML
₹180.40
MRP ₹220.00
18.00% OFF
Glydac Infusion 100ml
Glydac Infusion 100ml
Ikon Remedies Pvt Ltd
Pack of 100 ML
₹87.33
MRP ₹175.00
50.10% OFF

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