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Glycopyrrolate / Glycopyrronium + Neostigmine

Uses of Glycopyrrolate / Glycopyrronium + Neostigmine

  • The primary use of the combination medication Glycopyrrolate / Glycopyrronium + Neostigmine is to reverse neuromuscular blockade that has been induced by non-depolarizing neuromuscular blocking agents during surgery. This medication falls under the categories of antimuscarinic agents and cholinesterase inhibitors.

Side effects of Glycopyrrolate / Glycopyrronium + Neostigmine

  • Nausea and vomiting

  • Dry mouth

  • Hypertension or hypotension

  • Respiratory issues

How Glycopyrrolate / Glycopyrronium + Neostigmine works

  • Neostigmine is a cholinesterase inhibitor. It works by blocking the action of an enzyme (acetylcholinesterase) that breaks down a neurotransmitter called acetylcholine in the nerve-muscle junction. This increases the level of acetylcholine, leading to improved muscle contraction and helping to reverse paralysis.

  • Glycopyrrolate / Glycopyrronium is an antimuscarinic agent. It acts by blocking the peripheral effects of excess acetylcholine, a potential side effect of Neostigmine. This helps to counterbalance any unwanted effects such as slowing heart rate, increased secretions, or excessive activity in the gut.

  • Thus, in combination, these two components work together, effectively restoring muscle function after surgery while minimising potential side effects.

Certified content

Written By

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Dr. Michelle FrankMedical Content Writer| 8 years

Doctor of Medicine

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Glycopyrrolate / Glycopyrronium + Neostigmine is taken intravenously (injection).

Age and Dose Restrictions

  • This medication is primarily intended for use in adults undergoing surgical procedures.

Contraindications

  • The use of Glycopyrrolate / Glycopyrronium + Neostigmine is contraindicated in patients with known hypersensitivity to either medicine. Additionally, patients with mechanical obstruction of the gastrointestinal or urinary tract, peritonitis, and conditions such as late pregnancy should avoid this medication.

Other Medications to Avoid

  • The Glycopyrrolate / Glycopyrronium + Neostigmine combination may interact with anticholinergic medications (e.g., atropine and scopolamine), cholinergic agents (e.g., pilocarpine and succinylcholine) and aminoglycoside antibiotics (such as gentamicin and neomycin).

Overdose and Missed Dose

  • An overdose of Glycopyrrolate / Glycopyrronium + Neostigmine may result in symptoms of severe muscle weakness or paralysis. If any such symptoms are observed, immediate medical attention should be sought.

  • If a dose is missed, it should be administered as soon as possible. However, the missed dose should be skipped if it is almost time for the next scheduled dose.

Management of Side Effects

Most side effects of this medication are temporary and resolve upon discontinuation. However, if severe side effects are experienced or symptoms worsen, it is advisable to consult a doctor.

  • Drinking plenty of fluids can aid in managing side effects such as dry mouth.

  • Regular rest can help manage fatigue or dizziness associated with this medication.

Use in Driving and Operating Machinery

  • Glycopyrrolate / Glycopyrronium + Neostigmine may cause drowsiness and impact your ability to drive or operate heavy machinery. It is advisable to avoid such activities until you know how this medicine affects you.

Use in Pregnancy and Lactation

  • The use of this combination should be approached with caution during pregnancy and lactation. Always consult your doctor before using this medicine during these periods.

Caution in Other Conditions

  • Patients with cardiovascular disease, asthma, renal impairment, or intestinal obstruction should exercise caution when receiving Glycopyrrolate / Glycopyrronium + Neostigmine.

Special Dietary and Lifestyle Recommendations

  • Maintaining a balanced diet can help manage the potential gastrointestinal side effects such as constipation and nausea.

  • Regular hydration can help manage dry mouth, a potential side effect of this medication.

  • Regular rest periods may be beneficial for those who experience fatigue or drowsiness as a result of administering this medication.

Frequently asked questions

Unfortunately, no known natural alternatives to Glycopyrrolate / Glycopyrronium + Neostigmine exist. This combination is a specific medical intervention used to reverse the effects of certain agents used during surgery.

While Glycopyrrolate / Glycopyrronium + Neostigmine primarily acts on the neuromuscular system, it does not directly influence mood or hormones. However, if you notice any unusual changes in mood or hormonal symptoms while using this medication, consult your doctor.

Glycopyrrolate / Glycopyrronium + Neostigmine is typically given in an injectable form and does not contain animal-derived components. However, for confirmation of vegetarian or vegan suitability, consult your doctor or pharmacist.

Though rare, some people may develop an allergy to the ingredients in this medication. If you experience symptoms such as rash, itching, difficulty breathing or swelling after administration, seek immediate medical attention.

Glycopyrrolate / Glycopyrronium + Neostigmine primarily works on the musculoskeletal system and there is no scientific evidence to suggest that it affects mood. However, if you notice changes in your mood or mental state after administering this medicine, please consult your doctor.

This combination medicine is not available over the counter and requires a doctor's prescription for purchase and use.

No, Glycopyrrolate / Glycopyrronium + Neostigmine is not a steroid. It is a combination medicine primarily used to reverse the effects of non-depolarizing neuromuscular blocking agents that are given during surgery.

Terms & Conditions


Available medicines for GLYCOPYRROLATE / GLYCOPYRRONIUM + NEOSTIGMINE
Stimin G 0.5/2.5 MG Injection 5 ML
Stimin G 0.5/2.5 MG Injection 5 ML
Celon Labs
Pack of 5 ML
₹31.22
MRP ₹38.07
18.00% OFF
Neotagmin P Injection 5 ML
Neotagmin P Injection 5 ML
Themis Medicare Ltd.
Pack of 5 ML
₹58.63
MRP ₹71.50
18.00% OFF
Neoglyate Injection 5 ML
Neoglyate Injection 5 ML
Zydus Cadila
Pack of 5 ML
₹32.80
MRP ₹40.00
18.00% OFF
Pyrotroy Neo Injection 5 ML
Pyrotroy Neo Injection 5 ML
Troikaa Pharmaceuticals Ltd
Pack of 5 ML
₹48.54
MRP ₹59.20
18.00% OFF
Myo Pyrolate 0.5/2.5 MG Injection 5 ML
Myo Pyrolate 0.5/2.5 MG Injection 5 ML
Neon Laboratories Ltd
Pack of 5 ML
₹63.30
MRP ₹77.20
18.00% OFF

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