Human Insulin/soluble Insulin + Insulin Isophane/nph
Uses of Human Insulin/soluble Insulin + Insulin Isophane/nph
The primary use of Human Insulin/Soluble Insulin + Insulin Isophane/NPH is to manage blood sugar levels in people with type 1 and type 2 diabetes. It falls under the category of antidiabetic medicines.
Side effects of Human Insulin/soluble Insulin + Insulin Isophane/nph
Hypoglycaemia (low blood sugar)
Injection site reactions
Weight gain
Sodium retention
Lipodystrophy at injection sites
How Human Insulin/soluble Insulin + Insulin Isophane/nph works
Human Insulin/Soluble Insulin + Insulin Isophane/NPH is a combination of short-acting and intermediate-acting insulins used to manage blood glucose levels in diabetes.
The soluble human insulin component acts rapidly and is short-acting. It works swiftly to reduce high blood sugar levels in the body after meals.
The Insulin Isophane (NPH), on the other hand, is an intermediate-acting insulin. Its action is delayed but lasts for a longer duration, thus ensuring a continuous supply of insulin to control blood sugar levels between meals and during sleep. Together, these two components work to mimic the natural pattern of insulin release in a healthy body. They help in facilitating the cellular uptake of glucose and inhibit the production of glucose in the liver. This dual action helps to maintain a consistent blood glucose level throughout the day and night.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Human Insulin/Soluble Insulin + Insulin Isophane/NPH is available in the form of a suspension for subcutaneous injection.
Age and Dose Restrictions
The medicine is used in the management of both type 1 and type 2 diabetes in adults of age above 18 years.
Contraindications
This medicine is contraindicated for individuals who have a known hypersensitivity to any component of Human Insulin/Soluble Insulin + Insulin Isophane/NPH.
Additionally, it should not be used during episodes of hypoglycemia (low blood sugar).
Other Medications to Avoid
Human Insulin/Soluble Insulin + Insulin Isophane/NPH may interact with oral antidiabetic medicines (such as metformin), corticosteroids (like prednisolone), thyroid hormones (like levothyroxine), beta-blockers (such as propranolol), ACE inhibitors (for example, lisinopril) and certain psychiatric medications (including fluoxetine and clozapine).
Overdose and Missed Dose
An overdose of this medication could potentially lead to hypoglycemia. Symptoms include sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness or tingling hands/feet. Seek immediate medical attention if you suspect an overdose.
If you miss a dose, administer it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose and continue with your regular schedule. Do not administer double doses.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
For mild injection site reactions, try applying a clean, cold compress to the area.
Hypoglycemia can usually be managed by consuming a quick source of sugar such as glucose gel, fruit juice, or non-diet soda.
Use in Driving and Operating Machinery
This medication can cause hypoglycemia which may affect your ability to drive or operate machinery. If you experience symptoms like dizziness, confusion, or blurred vision, avoid these activities until you feel well again.
Use in Pregnancy and Lactation
It is recommended that you consult your doctor before using this medicine during pregnancy or while breastfeeding. Your doctor will be able to assess the risks and benefits based on your specific circumstances.
Caution in Other Conditions
Patients with kidney or liver impairment may need to have their dose adjusted as they can be more sensitive to the glucose-lowering effect of insulin.
Also, individuals with certain heart conditions should exercise caution when using this medication due to the potential for fluid retention.
Special Dietary and Lifestyle Recommendations
Maintain a consistent eating schedule to help prevent hypoglycemia.
Regular monitoring of blood glucose levels is essential for managing diabetes effectively.
Frequently asked questions
Is Human Insulin/Soluble Insulin + Insulin Isophane/NPH a steroid?
No, Human Insulin/Soluble Insulin + Insulin Isophane/NPH is not a steroid. It is an insulin-based medicine used to manage blood sugar levels in people with diabetes.
Does Human Insulin/Soluble Insulin + Insulin Isophane/NPH have any effect on mood?
Human Insulin/Soluble Insulin + Insulin Isophane/NPH primarily focuses on managing blood sugar levels. However, hypoglycemia, a side effect that can occur due to improper dosage, can lead to mood changes such as irritability and confusion.
Can Human Insulin/Soluble Insulin + Insulin Isophane/NPH affect menstruation?
Human Insulin/Soluble Insulin + Insulin Isophane/NPH is not associated with impacting menstruation. However, uncontrolled blood sugar levels can disrupt the menstrual cycle. Therefore, ensure your blood sugar levels are well-managed.
What is the half-life of Human Insulin/Soluble Insulin + Insulin Isophane/NPH in the body?
The half-life of this insulin combination varies, but it generally lasts in the body for about a few hours. The duration can differ based on various factors such as individual metabolic rates, injection site, and overall health status.
Are there any natural alternatives to Human Insulin/Soluble Insulin + Insulin Isophane/NPH?
While some natural substances may help maintain blood sugar levels, they cannot replace insulin in treating diabetes. Always consult your doctor before making any changes to your medication plan.
Are there any vegetarian/vegan alternatives to Human Insulin/Soluble Insulin + Insulin Isophane/NPH?
Insulin is a hormone produced naturally in the body. Although it is derived from recombinant DNA technology using yeast or bacteria, it does not contain any animal-derived ingredients and can be considered suitable for vegetarians and vegans.
Can Human Insulin/Soluble Insulin + Insulin Isophane/NPH cause dependency or withdrawal symptoms?
No, insulin does not cause dependency or withdrawal symptoms. However, abruptly stopping insulin can lead to high blood sugar levels and serious health complications. Always consult your doctor before making any changes to your diabetes management plan.
Human Insulin/soluble Insulin + Insulin Isophane/nph in other salts
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