Human Premix Insulin
ANTIDIABETICUses of Human Premix Insulin
- Human premix insulin is used to control blood sugar/improve glycemic control in patients with Diabetes mellitus. It is a fixed ratio premix recombinant human insulin formulation for adult patients.
- It is also helpful in reducing the risk of developing a heart attack, stroke or other diabetes-related complications such as kidney failure, liver damage, eye problems and gum diseases.
Side effects of Human Premix Insulin
- Hypoglycemia
- Weight gain
- Injection-site reactions(swelling, itchy and red-coloured skin)
- Edema (Swelling of hand and feet)
- Lipodystrophy (loss of fatty tissue in certain areas of the body)
How Human Premix Insulin works
- Human premix insulin works by stimulating the uptake of glucose from the blood and moving it into the cells where it can be utilised.
- It also inhibits the production of glucose by the liver and also promotes the metabolism of carbohydrates, proteins and fats.
Certified content
Written By
B. Pharm
Reviewed By
B. Pharm, MSc.
Expert Advice
Dosage Forms Available
- Human premix insulin is available for use via parenteral (subcutaneous injection only in abdominal wall, thigh, upper arm, or buttocks)
Age And Dose Restrictions
- It is used in both adults and children.
Contraindications
- It is contraindicated if you are allergic to any type of insulin or any other medication.
Medications To Avoid With This Drug
- Avoid taking oral contraceptives, beta-blockers (metoprolol, propranolol),
- Anti-depressants (fluoxetine, sertraline) and diuretics.
Overdose And Missed Dose
- If you miss taking a dose of Human premix insulin, ask your doctor about it and make sure to take note of it for future reference.
- Overdose of human premix insulin can cause hypoglycemia. Symptoms of hypoglycemia are confusion, palpitations, sweating, headache. Prompt management of an overdose is warranted. If hypoglycemia is mild, oral administration of glucose and sugar products will suffice. If hypoglycemia is severe it requires intramuscular or subcutaneous administration of glucagon followed by oral glucose, when the patient recovers.
Management Of Side Effects
- Keep a quick source of glucose on hand, such as a small pack of sugar or a glucose gel tube. Consuming these can help raise your blood sugar levels quickly.
Use In Driving And Operating Machinery
- It may cause dizziness or blurred vision in some individuals. If you experience these side effects, avoid driving or operating machinery until they subside.
Use In Pregnancy And Lactation
- Caution is advised for use of Human Premix insulin in Pregnant and Lactating females.
Caution In Other Conditions
- Patients with Liver and kidney disease need dose adjustment and more frequent blood glucose monitoring.
Special Dietary And Lifestyle Recommendation
- Alcohol consumption should be avoided when using human premix insulin.
- Do not take this medication, if you are allergic to human premix insulin. Serious allergic reactions should be dealt with with a proper doctor’s help. The symptoms include rash all over the body, trouble breathing, fast heartbeat and sweating.
- Your human premix insulin dose may need to be changed based on the change in the level of physical activity, weight gain or loss, increased stress or illness and change in diet.
- Lifestyle modifications like dietary changes and regular exercises are essential in maintaining adequate glycemic control.
Frequently asked questions
1. Is human premix insulin safe for use in pregnancy?
Human premix insulin is safe in pregnancy when the glycemic control is properly done. Monitoring of blood glucose levels is mandatory. However, it is prudent to inform your doctor regarding your pregnancy or a future plan about doing so.
2. How much time does it take to work?
It may take from 5-60 minutes for the Human premix insulin to manifest its action.
3. Is it safe for breastfeeding mothers?
Yes. Human premix insulin is safe in breastfeeding mothers with adequate dose adjustments.
4. What warnings and precautions should I take while using human premix insulin?
Human premix insulin can cause hypoglycemia which can be severe and life threatening if the dose is not titrated properly. Therefore patients are advised to monitor blood glucose levels regularly. Also they should keep altering the injection sites to avoid lipodystrophy at the site of injection.
5. Should I stop taking the medicine when I feel healthy?
No.The human premix insulin is usually prescribed for chronic conditions. Taking it regularly will make you feel normal and healthy.
6. Does it affect fertility?
No. Human premix insulin does not affect fertility.
7. Is it safe to drink alcohol while taking human premix insulin?
The glucose levels in the body may vary upon the consumption of alcohol. It is best to avoid alcohol while taking human premix insulin.
8. Does the use of human premix insulin cause lower blood sugar?
Yes, the human premix insulin can cause hypoglycemia. Monitor the blood glucose properly and increase the frequency when there are any changes in insulin intake like dosage patterns, meal changes, use of glucose-lowering medication and renal and liver impairment.
9. Does taking human premix insulin cause headaches?
Low blood sugar levels may cause headaches when taking human premix insulin. Keep a check on your blood glucose levels.
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