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Hydroxocobalamin

Uses of Hydroxocobalamin

  • Hydroxocobalamin is primarily used for the management of known or suspected cyanide poisoning and belongs to the category of Vitamin B12 analogue medications.

  • Additionally, it is also used in the management of Vitamin B12 deficiency in individuals who are unable to absorb Vitamin B12 from the intestine, such as in cases of pernicious anaemia or other similar conditions.

Side effects of Hydroxocobalamin

  • Red discolouration of the skin

  • Erythema (reddening or rash on the skin)

  • Nausea

  • Headache

  • Infusion site reactions

How Hydroxocobalamin works

  • Hydroxocobalamin is a form of vitamin B12.

  • It works by replenishing vitamin B12 levels in the body, which is vital for producing red blood cells, synthesizing DNA, and ensuring proper nerve function. Hydroxocobalamin binds to intrinsic factor, a protein necessary for its absorption in the intestines, and is then transported into the bloodstream to support various metabolic processes. Additionally, hydroxocobalamin is used as an antidote for cyanide poisoning; it binds to cyanide ions, forming a non-toxic compound that is safely excreted from the body.

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Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Hydroxocobalamin is available in injection form for intramuscular and intavenous administration.

Age and Dose Restrictions

  • Hydroxocobalamin is suitable for use in adults. It can also be administered to children, particularly in emergency situations involving cyanide poisoning, under strict medical supervision.

Contraindications

  • This medicine is contraindicated in individuals who have an allergy to cobalt or any form of vitamin B12.
  • It is also contraindicated in those with a known hypersensitivity to any component of the Hydroxocobalamin formulation.

Other Medications to Avoid

  • This medicine may interact with medicines affecting blood cell production (eg., chemotherapy medications like methotrexate), medicines that modify urine acidity (eg., diuretics like thiazides), and antihypertensives (eg., ACE inhibitors like enalapril).

Overdose and Missed Dose

  • An overdose of Hydroxocobalamin may lead to symptoms like high blood pressure, headaches, dizziness, or anxiety. If this happens, immediate medical help should be sought.
  • If you miss a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Avoid doubling the dose.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • Temporary itching or rash can often be alleviated by ensuring the injection site is clean and dry.
  • For headaches or light dizziness after injection, resting in a quiet, dark room may help.
  • Drinking plenty of fluids may assist in easing mild nausea following administration.

Use in Driving and Operating Machinery

  • The administration of Hydroxocobalamin might cause side effects like dizziness or blurred vision which could affect your ability to perform tasks requiring alertness such as driving or operating machinery. It is advisable to avoid these activities if you experience these esymptoms.

Use in Pregnancy and Lactation

  • It is recommended to use this medicine with caution if you are pregnant or nursing a child. Consulting a doctor is crucial before its administration during these periods.

Caution in Other Conditions

  • Patients with renal impairment should exercise caution while administering this medicine as its components are primarily excreted via the kidneys.

Special Dietary and Lifestyle Recommendations

  • Consuming foods rich in vitamin B12 can help manage conditions related to its deficiency. This includes meat, dairy products, and fortified cereals.
  • Regular monitoring of vitamin B12 levels through blood tests can help assess the need for adjustments in diet or medication.
  • Avoiding smoking and limiting alcohol consumption are advised as these can affect vitamin B12 absorption and overall health.
  • Engaging in stress-reducing activities such as yoga or meditation might improve overall well-being and aid in the management of symptoms associated with vitamin B12 deficiency disorders such as pernicious anaemia.

Frequently asked questions

Yes, Hydroxocobalamin is essentially a man-made form of vitamin B12. It is used as a medication and is classified as a vitamin B12 analogue.

Hydroxocobalamin, being a form of vitamin B12, is essential for proper neurological function. A deficiency in Vitamin B12 can lead to mood swings and other neurological issues.

Yes, it is true. One of the common adverse effects of Hydroxocobalamin is the red discolouration of the skin and mucous membranes. It can also cause red discolouration of the urine, which can last for several weeks after administration.

Indeed, one of the primary indications for Hydroxocobalamin is the management of known or suspected cyanide poisoning. It binds with cyanide molecules to form a non-toxic compound that is excreted in urine.

Hydroxocobalamin generally does not have significant interactions with foods. However, certain foods high in vitamin C may affect its absorption if taken in large amounts.

While there may be other forms of Vitamin B12 used in medications, it is important to use the medication prescribed by your doctor. Each medicine has its specific properties and indications, and your doctor would have considered various factors before prescribing Hydroxocobalamin.

Hydroxocobalamin should be used with caution in patients with a history of allergy to cobalt or vitamin B12. If you have known allergies, it's important to discuss this with your doctor before starting any new medication.

Terms & Conditions


Available medicines for HYDROXOCOBALAMIN
Trineurosol H Injection 1 ML
Trineurosol H Injection 1 ML
Wockhardt Ltd
Pack of 1 ML
₹10.18
MRP ₹12.41
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Trineurosol Hp Injection 1ml
Trineurosol Hp Injection 1ml
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Pack of 1 ML
₹10.18
MRP ₹12.41
18.00% OFF
Trineurosol Hp Injection 5ml
Trineurosol Hp Injection 5ml
Wockhardt Ltd
Pack of 5 ML
₹56.51
MRP ₹68.92
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Hcm Injection 1ml
Hcm Injection 1ml
Nutrigold India Pvt Ltd
Pack of 1 ML
₹20.50
MRP ₹25.00
18.00% OFF
Trinurosol Hp 1000 MG Injection 1 ML
Trinurosol Hp 1000 MG Injection 1 ML
Wockhardt Ltd
Pack of 1 ML
₹29.46
MRP ₹35.93
18.00% OFF
Trinurosol Hp 1000 MG Injection 5 ML
Trinurosol Hp 1000 MG Injection 5 ML
Wockhardt Ltd
Pack of 5 ML
₹45.51
MRP ₹55.50
18.00% OFF

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