Imeglimin
Uses of Imeglimin
Imeglimin belongs to the amino triazine class of medicines and is primarily used for the management of type 2 diabetes mellitus (T2DM). It assists in lowering blood glucose levels and improving glycemic control in patients suffering from T2DM. It is a novel oral antidiabetic medication.
Apart from the primary use, Imeglimin can be used as an adjunct to diet and exercise to further enhance the management regime of T2DM.
Side effects of Imeglimin
Headache
Nausea
Vomiting
Abdominal pain
Diarrhoea
How Imeglimin works
Imeglimin is a novel oral antidiabetic medication.
It works by improving the regulation of sugar in the body through multiple mechanisms. Firstly, it increases the amount of insulin released by the pancreas when sugar levels are high. Insulin is a hormone that helps cells absorb sugar from the blood, thereby lowering blood sugar levels. Secondly, Imeglimin improves the body's sensitivity to insulin, particularly in the liver and muscles. This means that these organs respond more effectively to insulin, further reducing blood sugar levels. Lastly, it targets mitochondria, which are the energy-producing components of cells. By enhancing their function and decreasing harmful oxidative stress, Imeglimin protects insulin-producing cells from damage caused by high sugar levels in the body.
Certified content
Written By
MD Ayurveda
Reviewed By
Bachelor of Dental Surgery
Expert Advice
Dosage Forms Available
Imeglimin can be taken orally (tablet).
Age and Dose Restrictions
Imeglimin is indicated for use in adults aged 18 and above.
Contraindications
Imeglimin is contraindicated in patients with severe liver or kidney disease. It should not be used by patients with a known hypersensitivity to Imeglimin or any of its components. Patients with metabolic acidosis, including diabetic ketoacidosis, should avoid using this medicine.
Other Medications to Avoid
Imeglimin can potentially interact with antiepileptic medications (such as lamotrigine and topiramate), antidepressants (like bupropion), heart medication (such as digoxin), anti-anginal medication (like ranolazine), antibiotics (such as cephalexin and ciprofloxacin) and anti-ulcer medication (like cimetidine).
Overdose and Missed Dose
If an overdose of Imeglimin occurs, general supportive measures should be employed, and symptomatic treatment should be given. Hemodialysis may be beneficial due to the medicine's low plasma protein binding.
If a dose of Imeglimin is missed, it should be taken as soon as remembered. However, if it is nearly time for the next dose, the missed dose should be skipped. Double dosage should be avoided.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of water might help manage gastrointestinal side effects like nausea, vomiting, abdominal pain, and diarrhea.
If you experience headaches after taking Imeglimin, try to rest and relax. A hot or cold compress may also help relieve the discomfort.
Use in Driving and Operating Machinery
Imeglimin does not typically interfere with the ability to drive or operate machinery. However, if you experience any side effects like dizziness or tiredness, it may be best to avoid these activities until such symptoms subside.
Use in Pregnancy and Lactation
It should only be used if the potential benefit to the mother outweighs the risk to the fetus. Nursing mothers should thus exercise caution and consult a doctor before using this medicine.
Caution in Other Conditions
Patients with impaired liver or kidney function should exercise caution when taking Imeglimin. Regular monitoring of renal function is advised before and during treatment with this medicine.
Special Dietary and Lifestyle Recommendations
Patients should also aim for adequate rest and stress management strategies to improve their overall health and well-being.
Frequently asked questions
Can Imeglimin cause weight gain?
Imeglimin is not directly associated with affecting weight. However, individual responses may vary, and it is best to discuss any concerns about weight changes with your doctor.
How long does it take for Imeglimin to show effect?
After oral administration, Imeglimin is rapidly absorbed, with peak plasma concentrations reached within 1-2 hours.
Is Imeglimin a steroid?
No, Imeglimin is not a steroid. It is a novel oral antidiabetic medicine.
Can vegetarians and vegans use Imeglimin?
Yes, Imeglimin tablets do not contain any animal-derived ingredients and should be suitable for vegetarians and vegans.
Will Imeglimin affect my appetite?
Imeglimin is not directly associated with affecting appetite. Consult your doctor for specific details.
Is there any natural alternative to Imeglimin?
While there might be natural substances that have anti-diabetic properties, it is essential to remember that they are not substitutes for prescribed medication like Imeglimin. Always consult your doctor before starting any new treatment.
How long does Imeglimin stay in the body?
Imeglimin has a half-life of approximately 5-6 hours. This means it takes about 5-6 hours for half of the medicine to be eliminated from the body.
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