Imipramine
Uses of Imipramine
Imipramine is chiefly utilised to manage depression and belongs to the group of tricyclic antidepressants.
Additionally, it is also used in children for the management of bedwetting (nocturnal enuresis).
Side effects of Imipramine
Dry mouth
Blurred vision
Constipation
Drowsiness
Weight gain
How Imipramine works
Imipramine is a member of the therapeutic category known as tricyclic antidepressants.
It inhibits the reuptake of two neurotransmitters in the brain, serotonin and norepinephrine. This leads to increased levels of these neurotransmitters in the brain, which improves mood and helps alleviate symptoms of depression. Additionally, Imipramine exhibits anticholinergic properties, which are thought to assist in managing bedwetting in children. This is achieved by reducing bladder contractility and increasing bladder capacity, thereby reducing the frequency of bedwetting episodes.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Imipramine is available for use via oral route (tablets, capsules, or oral solution).
Age and Dose Restrictions
This medicine is meant for adults.
Contraindications
The medicine is contraindicated in patients with known hypersensitivity to tricyclic antidepressants, including Imipramine. It is also not suitable for patients in the acute recovery phase following a heart attack.
Other Medications to Avoid
Imipramine may interact with monoamine oxidase inhibitors (such as isocarboxazid and moclobemide), selective serotonin reuptake inhibitors (like fluoxetine and citalopram), and antiarrhythmic medicines (like quinidine, flecainide).
Overdose and Missed Dose
An overdose of Imipramine may result in serious symptoms such as seizures, abnormal heart rhythms, and even coma. Consult your doctor immediately if you think you have overdosed on this medicine.
If you miss a dose of this medicine, take it as soon as you remember. If it's close to the time for your next dose, skip the missed dose and continue with your regular schedule.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve after discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
To deal with dry mouth, drink plenty of liquids and chew on sugar-free gum or hard candy.
If drowsiness or dizziness occurs, try to take the medication at bedtime to minimise daytime sleepiness.
Use in Driving and Operating Machinery
Imipramine may cause drowsiness, dizziness, or blurred vision which may affect your ability to drive or operate machinery. It is suggested to refrain from driving or operating heavy machinery until you know how this medicine affects you.
Use in Pregnancy and Lactation
Imipramine should be used during pregnancy and lactation only after consulting your doctor. The risks and benefits should be discussed thoroughly.
Caution in Other Conditions
Imipramine should be used with caution in patients with cardiovascular disorders, thyroid disorders, and in patients with liver or kidney impairment.
Special Dietary and Lifestyle Recommendations
Avoid the consumption of caffeine and other stimulants which might interfere with the effectiveness of this medicine, as well as worsen side effects such as insomnia.
Frequently asked questions
Is Imipramine a vegetarian medicine?
Imipramine is a chemical-based antidepressant and does not contain any ingredients derived from animals. However, certain formulations may use non-vegetarian ingredients as fillers or binders. It is best to check the package insert for detailed information regarding the ingredients.
Does Imipramine affect mood swings?
Imipramine is an antidepressant and works by increasing the levels of certain chemicals in the brain that help elevate mood and alleviate symptoms of depression. It may have a positive effect on mood swings associated with depressive disorders.
Can I develop a dependency on Imipramine?
Imipramine is not known to cause physical or psychological dependence. However, sudden discontinuation should be avoided as it may cause withdrawal symptoms such as nausea, headache, and malaise.
Can Imipramine cause hormonal imbalance?
Imipramine primarily affects neurotransmitters in the brain and is not known to directly affect hormonal balance. If you experience symptoms suggestive of a hormonal imbalance while taking this medication, consult your doctor for further advice.
Are there any natural alternatives to Imipramine?
While some natural substances are touted for their potential antidepressant properties, they are typically not as effective as prescribed medications like Imipramine. Consult your doctor before trying any alternative treatments for depression.
Does Imipramine affect menstrual cycle?
Imipramine may indirectly affect menstrual cycles in some women due to its influence on brain chemicals involved in promoting emotional well-being. If you notice changes in your menstrual cycle while taking this medication, consult your doctor.
Can Imipramine cause allergies?
Although uncommon, allergic reactions to Imipramine can occur. Symptoms of an allergic reaction include rash, itching, dizziness, trouble breathing, or swelling of the face, lips, or tongue. If you experience any of these symptoms, seek immediate medical attention.
Imipramine in other salts
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