Inclisiran

Dosage Forms Available

• Inclisiran is available as a subcutaneous injection.

• The route of administration for this medication is through injection beneath the skin (subcutaneous).

Age and Dose Restrictions

• Inclisiran is meant for use in adults only.

Contraindications

• This medicine is contraindicated in patients with a known hypersensitivity to any of its components.

Other Medications to Avoid

• This medicine may interact with anticoagulants (eg., Warfarin), statins (eg., Atorvastatin or Simvastatin), and certain immunosuppressants (eg., Cyclosporine).

Overdose and Missed Dose

• An overdose of Inclisiran has not been reported to cause specific symptoms, but general symptoms may occur. It is crucial to adhere to prescribed dosages, and if an overdose is suspected, medical attention should be sought.

• If a dose of Inclisiran is missed, it should be administered as soon as possible. If it is close to the time for the next scheduled dose, skip the missed dose and resume the regular dosing schedule. Do not double doses.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• Adjusting the timing of medication might help manage some side effects effectively.

• Drinking plenty of water can help alleviate minor side effects such as injection site reactions which may include pain or redness.

Use in Driving and Operating Machinery

• Inclisiran does not generally affect the ability to drive or operate machinery.

Use in Pregnancy and Lactation

• The safety of Inclisiran during pregnancy and breastfeeding has not been established. It is advised to consult a doctor before using this medicine during pregnancy and while breastfeeding.

Caution in Other Conditions

• Caution should be exercised when administering Inclisiran to patients with liver conditions since it mainly acts upon the liver cells.

Special Dietary and Lifestyle Recommendations

• Maintain a low-cholesterol diet rich in fruits, vegetables, whole grains, and lean proteins to help manage cholesterol levels.

• Increase intake of omega-3 fatty acids found in fish like salmon and mackerel which can help lower blood triglyceride levels.

• Consider adding plant sterols and stanols found in enriched foods like margarine, orange juice, or yoghurts that can help reduce LDL cholesterol by blocking its absorption from the digestive tract.

• Smoking cessation is crucial as smoking lowers HDL (good) cholesterol levels and damages blood vessel walls making them more prone to accumulation of fatty deposits.