Indapamide
Uses of Indapamide
The primary use of Indapamide is for the management of hypertension (high blood pressure), and it belongs to the group of medicines known as thiazide-like diuretics.
Additionally, it is indicated in the management of edema (fluid retention) caused by congestive heart failure. In some cases, doctors may prescribe Indapamide off-label for other conditions related to fluid overload.
Side effects of Indapamide
Nausea
Fatigue
Headache
Muscle cramps
Skin rash
How Indapamide works
Indapamide is a thiazide-like diuretic.
Its primary action is to increase the amount of salt and water the kidneys remove from the blood, leading to a reduction in blood volume and, consequently, lower blood pressure. Through a process called diuresis, or increased urine production, it flushes out extra sodium and water from the body to reduce fluid overload. Additionally, it relaxes and widens blood vessels, a process called vasodilation. This makes it easier for blood to flow through vessels, further reducing pressure on artery walls. It may involve blocking calcium channels and affecting prostaglandin production. These dual actions work in tandem to effectively manage hypertension and edema.
Certified content
Written By
BDS, MDS
Reviewed By
Bachelor of Dental Surgery
Expert Advice
Dosage Forms Available
- Indapamide can be taken orally (immediate-release tablet).
Age and Dose Restrictions
- This medicine is meant for adults and older adults.
Contraindications
- This medicine is contraindicated in patients with an allergy to Indapamide. It should not be used by individuals with severe kidney or liver impairment, anuria (the inability to produce urine), or electrolyte imbalances resistant to treatment, such as hypokalemia (low blood potassium) and hyponatremia (low blood sodium).
Other Medications to Avoid
- This medicine can interact with Non-steroidal Anti-inflammatory Drugs (NSAIDs) (such as diclofenac and ibuprofen), Mood stabilizers (lithium), cardiac glycosides (such as digoxin), and corticosteroids (like prednisone, dexamethasone).
Overdose and Missed Dose
- An overdose of this medication may lead to severe dehydration, electrolyte imbalances, low blood pressure, and circulatory collapse. In case of suspected overdose, seek immediate medical attention.
- If you forget to take a dose of Indapamide, take it as soon as you remember. But if it is almost time for your next dose, skip the missed dose. Do not take a double dose to make up for a missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
- Drinking plenty of water can help combat fluid loss associated with diuretic action.
- Taking the medication in the morning can help reduce the inconvenience of frequent urination during the night.
Use in Driving and Operating Machinery
- Indapamide may cause dizziness or fatigue. If affected, avoid driving or operating heavy machinery.
Use in Pregnancy and Lactation
- Indapamide should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult your doctor before using this medicine during pregnancy. It is not recommended for use while breastfeeding unless necessary, and the benefits outweigh the risks.
Caution in Other Conditions
- Patients with kidney impairment or liver disease need to exercise caution when taking this medicine.
- Caution is also advised in patients with systemic lupus erythematosus as this condition can be exacerbated by Indapamide.
Special Dietary and Lifestyle Recommendations
- Reducing salt intake can enhance the effectiveness of Indapamide in managing hypertension and fluid retention.
Frequently asked questions
Can Indapamide cause mood changes?
Although mood changes are not a common side effect of Indapamide, it can occur in some people. If you notice any unusual changes in your mood or behaviour, please inform your doctor.
Can I develop an allergy to Indapamide?
There is a possibility of having an allergic reaction to Indapamide if you are allergic to it or to sulfonamides, which are contained in the medicine.
Do I need a prescription for Indapamide?
Yes, Indapamide is a prescription medication and should only be taken as directed by your doctor.
Can Indapamide be used for weight loss?
No, Indapamide is not intended to be used for weight loss. It is a diuretic medication used to manage high blood pressure and fluid retention due to heart failure.
Is Indapamide a vegan-friendly medication?
The active ingredient, Indapamide, is synthesised and does not contain any animal-derived components. However, it is important to check the list of inactive ingredients or consult your doctor, as some may contain animal-derived substances.
What happens if I stop taking Indapamide suddenly?
Stopping Indapamide suddenly can potentially lead to withdrawal symptoms such as rebound high blood pressure. Therefore, it is crucial not to discontinue the medication without consulting your doctor.
Does Indapamide cause sun sensitivity?
Yes, photosensitivity reactions are possible with Indapamide use. Therefore, it is advisable to limit sun and UV exposure while taking this medicine.
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