Isoniazid + Rifampicin

Dosage Forms Available

• Isoniazid + Rifampicin can be taken orally (tablet, suspension and capsule).

Age and Dose Restrictions

• Isoniazid + Rifampicin is meant for use in adults and children.

Contraindications

• Isoniazid + Rifampicin is contraindicated in patients with known hypersensitivity to either isoniazid or rifampicin. It is also contraindicated in those with severe liver disease or acute liver failure, as well as individuals with a history of medicine-induced hepatitis or severe skin reactions with either isoniazid or rifampicin.

Other Medicines to Avoid

• The combination of Isoniazid + Rifampicin may interact with oral contraceptives (such as ethinyl estradiol and levonorgestrel), anticoagulants (such as warfarin), antidiabetic agents (like glyburide, glipizide), anticonvulsants (carbamazepine, phenytoin), protease inhibitors (indinavir, ritonavir), and corticosteroids (prednisone).

Overdose and Missed Dose

• An overdose of Isoniazid + Rifampicin can be harmful and could potentially cause liver damage, peripheral neuropathy, and blood disorders. If you suspect an overdose, seek immediate medical attention.

• If you forget to take a dose of Isoniazid + Rifampicin, take it as soon as you remember. However, if it's nearly time for the next dose, skip the missed one. Do not take a double dose to make up for the missed one.

Management of Side Effects

Most side effects of Isoniazid + Rifampicin are temporary and resolve once the medicine is discontinued. Consult your doctor if you experience severe side effects or if your symptoms worsen.

• For nausea or vomiting, try taking the medication with meals.

• For abdominal discomfort, try eating smaller, frequent meals instead of large ones.

• If you experience dizziness, avoid sudden movements and ensure you get up slowly from a sitting or lying position.

Use in Driving and Operating Machinery

• Isoniazid + Rifampicin may cause dizziness and fatigue. These side effects might affect your ability to drive or operate heavy machinery. Avoid these activities if you feel dizzy or fatigued after taking this medicine.

Use in Pregnancy and Lactation

• Consult your doctor before using this medicine during pregnancy or while breastfeeding.

Caution in Other Conditions

• Patients with pre-existing liver disease, alcohol abuse, malnutrition, advanced age, or renal impairment should exercise caution when taking Isoniazid + Rifampicin. Regular monitoring of liver function may be necessary.

Special Dietary and Lifestyle Recommendations

• Patients on Isoniazid + Rifampicin should maintain a healthy diet to support overall health and recovery from tuberculosis.

• Adherence to the prescribed medication regimen is crucial for effective management of tuberculosis.