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Ketamine

Uses of Ketamine

  • Ketamine, a dissociative anesthetic, is primarily used as a general anesthetic for diagnostic and surgical procedures that do not require skeletal muscle relaxation. 
  • It is also utilized for pain management in acute conditions like burn injuries and is being investigated for potential treatment of mental health conditions, including major depressive disorder, bipolar depression, and post-traumatic stress disorder.

Side effects of Ketamine

  • Increase in heart rate

  • Hypertension

  • Dizziness

  • Nausea

  • Urinary frequency

How Ketamine works

  • Ketamine is primarily a general anaesthetic
  • It works by acting as a non-competitive antagonist to a particular receptor in the brain named the N-Methyl-D-Aspartate (NMDA) receptor. In simpler terms, Ketamine blocks this receptor. These receptors play a role in transmitting messages between your brain cells, particularly those associated with pain and memory
  • By blocking these receptors, Ketamine creates a state of dissociative anaesthesia
  • This state involves a deep sense of relaxation, significant reduction of pain, and loss of memory, which makes it especially useful during surgical procedures as it allows for the management of pain and discomfort while keeping the patient calm and relaxed

Certified content

Written By

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Dr. Michelle FrankMedical Content Writer| 9 years

Doctor of Medicine

Reviewed By

Dr. Divya Chauhan
Dr. Divya Chauhan Medical Writer & Reviewer| 7 years

BAMS, APG, PG

Expert Advice

Dosage Forms Available

  • Ketamine is available for use as an infusion (intravenous or intramuscular) route

Age and Dose Restrictions

  • Ketamine can be given to adults and paediatric patients over the age of three months

Contraindications

  • This medicine is contraindicated in patients who have a known hypersensitivity to Ketamine or any of its components. It is also contraindicated in patients with a history of severe hypertension or severe cardiovascular disease

Other Medications to Avoid

  • Ketamine can interact with thyroid hormones (e.g., levothyroxine), and general anaesthetics (e.g., propofol)

Overdose and Missed Dose

  • An overdose of Ketamine may cause severe hallucinations, changes in blood pressure, heart rate abnormalities, severe breathing problems, and severe nausea or vomiting. In the event of an accidental overdose, seek immediate medical attention

  • If you miss a dose of this medicine, you should administer it as soon as possible. However, if it is near the time for the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up

Management of Side Effects

Most side effects of Ketamine are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any symptoms, please consult your doctor.

  • Drinking small amounts of water throughout the day can help manage dry mouth

  • If you feel drowsy or dizzy after administration, rest until you feel okay to get up

Use in Driving and Operating Machinery

  • Ketamine can cause drowsiness, dizziness, and altered consciousness. Therefore, it may affect your ability to drive or operate machinery safely. Avoid performing these activities if you feel affected after the administration of the medicine

Use in Pregnancy and Lactation

  • Ketamine is classified as a pregnancy category C medication. It should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus. Consult your doctor before using this medicine during pregnancy and breastfeeding

Caution in Other Conditions

  • Patients with cardiovascular disease, increased intracranial pressure, elevated intraocular pressure, thyroid disorders, and a history of medicine abuse should exercise caution when receiving Ketamine

Special Dietary and Lifestyle Recommendations

  • Ketamine can affect mood and cognition. Be aware of any changes in mood or cognitive function and report them to your doctor

  • Regular monitoring of blood pressure is advisable for patients receiving this medicine due to its potential to affect blood pressure levels

Frequently asked questions

Yes, Ketamine can cause sedation. This is why it is often used as an anaesthetic during surgeries to put patients to sleep.

Ketamine is not known to directly affect fertility. However, like with any medicine, it is best to consult your doctor if you are planning a pregnancy or are already pregnant.

The safety of daily Ketamine use depends on the individual's health condition and the doctor's prescription. It is not advised to use this medication without a doctor's recommendation.

Ketamine generally starts to work within a few minutes of administration. The exact time may vary based on the individual's response and the method of administration.

The best time to administer Ketamine depends on the doctor's advice and the specific medical procedure for which it is being used.

The duration of treatment with Ketamine varies based on individual conditions and response to therapy. It is important to adhere to your doctor's instructions.

Ketamine usually requires a doctor's prescription and is not typically available over the counter.

Terms & Conditions

List of Medicines for Ketamine

Aneket 100 MG Injection 2 ML
Aneket 100 MG Injection 2 ML
Neon Laboratories Ltd
Pack of 2 ML
₹18.8
MRP ₹23.5
20% OFF
Aneket 50 MG Injection 5 ML
Aneket 50 MG Injection 5 ML
Neon Laboratories Ltd
Pack of 5 ML
₹48
MRP ₹60
20% OFF
Ketajet 50 MG Injection 2 ML
Ketajet 50 MG Injection 2 ML
Sterkem
Pack of 2 ML
₹17.68
MRP ₹22.1
20% OFF
Aneket 50 MG Injection 10 ML
Aneket 50 MG Injection 10 ML
Neon Laboratories Ltd
Pack of 10 ML
₹81
MRP ₹101.25
20% OFF
Aneket 50 MG Injection 2 ML
Aneket 50 MG Injection 2 ML
Neon Laboratories Ltd
Pack of 2 ML
₹16
MRP ₹20
20% OFF
Aneket 500 MG Injection 10 ML
Aneket 500 MG Injection 10 ML
Neon Laboratories Ltd
Pack of 10 ML
₹81
MRP ₹101.25
20% OFF
Aneket 10 MG Injection 10 ML
Aneket 10 MG Injection 10 ML
Neon Laboratories Ltd
Pack of 10 ML
₹87.6
MRP ₹109.5
20% OFF
Ketajet 50 MG Injection 10 ML
Ketajet 50 MG Injection 10 ML
Sterkem
Pack of 10 ML
₹76
MRP ₹95
20% OFF

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