L-methylfolate Calcium
Uses of L-methylfolate Calcium
L-Methylfolate Calcium is primarily used to manage folate deficiency and is part of the group of vitamin B9 supplements.
Secondary uses include adjunctive treatment for major depressive disorder, prevention of neural tube defects during pregnancy, and lowering homocysteine levels - a risk factor for cardiovascular disease.
Side effects of L-methylfolate Calcium
Nausea
Diarrhoea
Sleep disturbances
Irritability or excitability
Allergic reactions such as rash, itching, and swelling
How L-methylfolate Calcium works
L-Methylfolate Calcium is a type of vitamin supplement.
It bypasses the enzymatic conversion steps required by regular folic acid, allowing it to directly participate in the methylation process. This helps produce neurotransmitters like serotonin, dopamine, and norepinephrine, essential for mood regulation and cognitive function. It supports cellular processes, DNA synthesis, and repair through its role in methylation.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
L-Methylfolate Calcium can be taken orally (tablets and capsules), intravenous (infusion), and intramuscular (injection) routes.
Age and Dose Restrictions
This medicine is suitable for use in adults and children, but specific age-related guidance should be followed as per medical advice.
Contraindications
L-Methylfolate Calcium is contraindicated in patients with known hypersensitivity to folate or any components of the formulation.
Other Medications to Avoid
L-Methylfolate Calcium can interact with anticonvulsants (such as phenytoin, carbamazepine), chemotherapeutic agents (like methotrexate), and medicines affecting intestinal absorption (like sulfasalazine).
Overdose and Missed Dose
An overdose of L-Methylfolate Calcium may lead to symptoms like confusion, irritability, or disturbed sleep. In case of suspected overdose, it is important to seek medical attention promptly.
If a dose of L-Methylfolate Calcium is missed, it should be taken as soon as remembered unless it is almost time for the next dose. In that case, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to catch up.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
If experiencing mild nausea or an upset stomach, try taking L-Methylfolate Calcium with food.
If mild diarrhoea occurs, ensure adequate hydration by drinking plenty of fluids.
Use in Driving and Operating Machinery
There is no direct impact of L-Methylfolate Calcium on the ability to drive or operate machinery. However, if you experience any side effects that could impair your ability to perform these activities safely, such as dizziness or drowsiness, avoid engaging in these activities.
Use in Pregnancy and Lactation
L-Methylfolate Calcium is considered safe for use during pregnancy and lactation as it plays a crucial role in fetal development and maternal health. Nonetheless, it is advisable to consult a doctor before starting this medication during pregnancy or while breastfeeding.
Caution in Other Conditions
Individuals with a history of allergies or hypersensitive reactions should exercise caution when using L-Methylfolate Calcium.
While there are no broad restrictions for other conditions, consulting a doctor before starting L-Methylfolate Calcium can provide personalised advice based on individual health conditions.
Special Dietary and Lifestyle Recommendations
Maintain a balanced diet rich in natural sources of folate such as green leafy vegetables, beans, peas, and nuts which can complement the effects of L-Methylfolate Calcium.
Regular moderate exercise can help enhance overall health and aid the physiological processes supported by folate.
Avoid excessive alcohol consumption as it can interfere with folate absorption and utilisation in the body.
Since stress can impact overall health including folate levels, adopting stress reduction techniques such as mindfulness or yoga might be beneficial.
Frequently asked questions
How Does L-Methylfolate Calcium Differ from Regular Folate in Vitamin Supplements?
L-Methylfolate Calcium is a form of vitamin B9 or folate that is biologically active. This means your body can use it directly without requiring additional metabolic processes, unlike the traditional synthetic folate found in most supplements.
Can L-Methylfolate Calcium Improve My Mood?
L-Methylfolate Calcium may have benefits in managing symptoms of depression. It supports the synthesis of neurotransmitters like serotonin, dopamine, and norepinephrine that are critical for mood regulation.
Can L-Methylfolate Calcium Boost My Immunity?
While L-Methylfolate Calcium doesn't directly boost immunity, it contributes to overall health by supporting DNA synthesis, cell division, and protein production. These processes are vital for maintaining a strong immune system.
Can L-Methylfolate Calcium Help in Losing Weight?
There is no direct evidence linking L-Methylfolate Calcium with weight loss. However, since it plays a critical role in many bodily functions including metabolism, maintaining recommended levels can support overall health including healthy weight management.
What Happens if I Take Too Much L-Methylfolate Calcium?
Consuming excessive amounts of L-Methylfolate Calcium over an extended period could potentially mask a vitamin B12 deficiency, leading to neurological complications if left untreated.
Is L-Methylfolate Calcium Suitable for Vegetarians and Vegans?
Yes, L-Methylfolate Calcium is suitable for both vegetarians and vegans since it is a type of vitamin B9 and can be derived from vegetarian and vegan sources.
Can I take L-Methylfolate Calcium if I am allergic to Folic Acid?
Since L-Methylfolate Calcium is a type of folic acid, individuals with a known allergy to folic acid should avoid taking it.
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