Lapatinib

Dosage forms available

• Lapatinib is available as oral tablets.

Age and dose restrictions

• This medication is meant for adult use only.

Contraindications

• This medicine is contraindicated in patients with known hypersensitivity or allergies to Lapatinib. Patients with severe liver disease should also avoid using this medicine due to its potential to cause further hepatic damage.

Other medications to avoid with this medicine

• Lapatinib may interact with strong inhibitors of CYP3A4 enzymes (such as ketoconazole, itraconazole, and clarithromycin) and strong inducers of CYP3A4 (like rifampin, phenytoin, St. John's wort).

Overdose and missed dose

• If an overdose of Lapatinib occurs, it could lead to severe symptoms such as chest pain, shortness of breath, or fainting. Should you suspect an overdose, seek immediate medical assistance.
• In the event of a missed dose, take the medication as soon as you remember. However, if it is closer to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not take double doses to make up for the missed one.

Management of side effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening symptoms, please consult your doctor.

• Maintaining good hydration by drinking plenty of fluids to manage common side effects like diarrhoea.
• For skin reactions such as rash, use over-the-counter topical creams or ointments that relieve itching and irritation.
• In case of nausea, try eating smaller, more frequent meals instead of large ones.

Use in driving and operating machinery

• Lapatinib may cause fatigue and dizziness, which could affect your ability to drive or operate heavy machinery. If you experience these side effects, avoid such activities until these symptoms are managed.

Use in pregnancy and lactation

• Due to potential risks to the foetus, Lapatinib should not be used during pregnancy. Women of childbearing age should use effective contraception while on this medication.
• Breastfeeding is not recommended while taking Lapatinib.

Caution in other conditions

• Patients with a history of heart disease should exercise caution when taking Lapatinib as it can affect heart function. Regular monitoring of cardiac health is recommended in these cases.

Special dietary and lifestyle recommendation

• It is advisable to maintain a balanced diet while on Lapatinib therapy to help manage potential side effects like loss of appetite or nausea.
• Regular moderate physical activity can also contribute to overall well-being and help manage fatigue associated with the disease and its treatment.
• Avoid consuming grapefruit or grapefruit juice while on Lapatinib therapy as it may interact with the medication and increase its levels in the body.