Lenvatinib

Dosage Forms Available

• Lenvatinib can be taken orally (capsule).

Age and Dose Restrictions

• Lenvatinib is approved for use in adults.

Contraindications

• Lenvatinib is contraindicated for individuals who have shown hypersensitivity to the active ingredient, Lenvatinib, or any other ingredients in the capsule.

Other Medications to Avoid

• This medicine may interact with strong antifungals (such as ketoconazole and itraconazole) and antibiotics (like rifampicin and phenytoin).

Overdose and Missed Dose

• There is no specific antidote for Lenvatinib overdose. In case of suspected overdose, supportive care should be provided as necessary.

• If you miss a dose of Lenvatinib, you should take it as soon as possible. However, if it is less than 12 hours until your next scheduled dose, then you should skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• Drinking plenty of water may help manage some side effects like diarrhoea.

• Resting or reducing physical activity may help manage fatigue.

• Drinking cool water may help manage stomatitis (mouth sores).

Use in Driving and Operating Machinery

• Lenvatinib may cause fatigue and dizziness, which could affect your ability to drive or operate machinery. It is advisable to avoid such activities if you experience these side effects.

Use in Pregnancy and Lactation

• Lenvatinib can cause harm to the foetus and is not recommended for use during pregnancy. It is not known if Lenvatinib is excreted in human milk. Breastfeeding should be discontinued during treatment and for at least one week after the last dose. Lactating mothers should consult with their doctor before starting the medication.

Caution in Other Conditions

• Caution should be exercised while administering Lenvatinib to patients with severe renal impairment or hepatic impairment, as its safety and effectiveness in these conditions are not well-established.

• Patients with a history of hypertension, heart disease, or kidney problems should be closely monitored when taking this medication.

Special Dietary and Lifestyle Recommendations

• Regular mild exercise can help improve the physical stamina of patients.

• Regular follow-ups with the doctor are necessary to monitor the progress of treatment.