Lenvatinib
Uses of Lenvatinib
Lenvatinib is primarily used to manage a range of cancers, including thyroid cancer, kidney cancer, liver cancer, and endometrial cancer. It belongs to the group of tyrosine kinase inhibitors.
Side effects of Lenvatinib
High blood pressure
Diarrhoea
Fatigue
Decreased appetite
Nausea and vomiting
How Lenvatinib works
Lenvatinib is a type of medicine known as a tyrosine kinase inhibitor.
It works by blocking the action of specific enzymes called tyrosine kinases. These enzymes play a key role in promoting the growth and spread of cancer cells. By blocking these enzymes, Lenvatinib interrupts the growth and proliferation of cancer cells, helping to slow down or halt their spread within the body.
Certified content
Written By
BDS, MDS
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Lenvatinib can be taken orally (capsule).
Age and Dose Restrictions
Lenvatinib is approved for use in adults.
Contraindications
Lenvatinib is contraindicated for individuals who have shown hypersensitivity to the active ingredient, Lenvatinib, or any other ingredients in the capsule.
Other Medications to Avoid
This medicine may interact with strong antifungals (such as ketoconazole and itraconazole) and antibiotics (like rifampicin and phenytoin).
Overdose and Missed Dose
There is no specific antidote for Lenvatinib overdose. In case of suspected overdose, supportive care should be provided as necessary.
If you miss a dose of Lenvatinib, you should take it as soon as possible. However, if it is less than 12 hours until your next scheduled dose, then you should skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of water may help manage some side effects like diarrhoea.
Resting or reducing physical activity may help manage fatigue.
Drinking cool water may help manage stomatitis (mouth sores).
Use in Driving and Operating Machinery
Lenvatinib may cause fatigue and dizziness, which could affect your ability to drive or operate machinery. It is advisable to avoid such activities if you experience these side effects.
Use in Pregnancy and Lactation
Lenvatinib can cause harm to the foetus and is not recommended for use during pregnancy. It is not known if Lenvatinib is excreted in human milk. Breastfeeding should be discontinued during treatment and for at least one week after the last dose. Lactating mothers should consult with their doctor before starting the medication.
Caution in Other Conditions
Caution should be exercised while administering Lenvatinib to patients with severe renal impairment or hepatic impairment, as its safety and effectiveness in these conditions are not well-established.
Patients with a history of hypertension, heart disease, or kidney problems should be closely monitored when taking this medication.
Special Dietary and Lifestyle Recommendations
Regular mild exercise can help improve the physical stamina of patients.
Regular follow-ups with the doctor are necessary to monitor the progress of treatment.
Frequently asked questions
Is Lenvatinib a steroid?
No, Lenvatinib is not a steroid. It is a medication that belongs to the class known as tyrosine kinase inhibitors, used for managing certain types of cancer.
Can Lenvatinib cause sleep disturbances?
Lenvatinib is not known to cause sleep disturbances as a side effect of Lenvatinib. However, fatigue is a common side effect which could potentially impact your sleep. Consult your doctor if you experience any sleep-related issues while on this medication.
Does Lenvatinib affect fertility?
As per the research data, women of childbearing potential are advised to use effective contraception during treatment and for at least 30 days after the last dose, as Lenvatinib can cause harm to the fetus. However, there is no specific mention of Lenvatinib affecting fertility.
Is it safe to take Lenvatinib daily?
Yes, it is safe to take Lenvatinib daily if it is prescribed by your doctor. The doctor will determine the correct dosage based on your condition and response to treatment.
How long does it take for Lenvatinib to start working?
The time it takes for Lenvatinib to show effects can vary among individuals, and some may see improvements within a few weeks while others may take several months. Regular follow-ups with your doctor are important to monitor progress and adjust treatment as necessary.
How long do I need to take Lenvatinib?
The duration of treatment with Lenvatinib depends on your condition and how your body responds to the medication. Your doctor will decide the duration of treatment based on these factors.
Is Lenvatinib safe for long-term use?
The safety of long-term use of Lenvatinib is determined by your doctor based on your individual health condition and response to the medicine. It is important to regularly consult your doctor during your treatment with Lenvatinib.
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