Leucovorin Calcium
Uses of Leucovorin Calcium
The primary use of Leucovorin Calcium is to reduce the toxic effects of methotrexate and other folate antagonists. It belongs to the folate analogues class of medicines.
It is also used to treat megaloblastic anaemia and to provide palliative treatment for colorectal cancer.
Side effects of Leucovorin Calcium
Allergic reactions such as rashes, hives, itching
Diarrhoea
Nausea and vomiting
Stomatitis, which is inflammation of the mouth and lips
Fatigue and fever
How Leucovorin Calcium works
Leucovorin Calcium belongs to the folate analogue class of medicines.
It acts like a ready-made form of folic acid, which is important for making DNA and RNA in cells. It helps cells continue their normal processes without needing extra steps to break down folic acid. Additionally, it can help reduce the harmful effects of another medicine called methotrexate by competing with it for entry into cells.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Leucovorin Calcium can be taken orally (in tablet form) or administered intramuscularly or intravenously (via infusion).
Age and Dose Restrictions
This medicine is meant for adults and children.
Contraindications
Leucovorin Calcium is contraindicated in patients with known hypersensitivity to Leucovorin Calcium or any other components of this medicine.
Other Medications to Avoid
Leucovorin Calcium may interact with antiepileptic medicines (such as phenobarbital, phenytoin, primidone).
Overdose and Missed Dose
An overdose of Leucovorin Calcium may cause severe side effects like seizures and allergic reactions. If you observe these symptoms, inform your doctor and follow their advice accordingly.
If you forget to take this medicine, take it as soon as you remember. If it is time for the next dose, skip the missed dose and continue your regular dosage regime.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve after discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of water can help manage common side effects such as diarrhoea and vomiting.
Resting and avoiding strenuous physical activity can help manage fatigue.
Use in Driving and Operating Machinery
Leucovorin Calcium can interact with your ability to drive or operate heavy machines. Do not drive or operate heavy machines if you feel fatigue, or dizziness after taking this medication.
Use in Pregnancy and Lactation
It is advisable to consult a doctor before using Leucovorin Calcium during pregnancy and breastfeeding.
Caution in Other Conditions
Patients with renal insufficiency or a history of seizures should exercise caution while taking Leucovorin Calcium.
Patients with dehydration or electrolyte imbalance, and those with pernicious anaemia or vitamin B12 deficiency anaemia should also exercise caution.
Special Dietary and Lifestyle Recommendations
A balanced diet with adequate folic acid intake can support overall health while taking Leucovorin Calcium.
Regular monitoring of blood parameters and kidney function is recommended.
Frequently asked questions
Is Leucovorin Calcium a type of vitamin?
Leucovorin Calcium is not a vitamin, but it is related to vitamins. It is a reduced form of folic acid (vitamin B9) and is used as a medication. It provides a form of folate that can be readily utilized by the body, especially in situations where normal folic acid metabolism might be impaired, such as during certain cancer treatments or to reduce the side effects of methotrexate.
Can Leucovorin Calcium cause mood changes?
Leucovorin Calcium does not typically cause mood changes. However, every individual can react differently to medications and it is always good to consult with your doctor if you notice any unexpected mood changes while taking Leucovorin Calcium.
Can vegetarians or vegans take Leucovorin Calcium?
Yes, there are no animal-derived ingredients in Leucovorin Calcium. However, it is always best to check the label or consult your doctor or pharmacist for confirmation.
Can Leucovorin Calcium alter menstrual cycles?
Leucovorin Calcium is not associated with affecting menstrual cycles. However, if you notice any changes in your menstrual cycle while taking this medicine, contact your doctor.
Does Leucovorin Calcium cause weight gain or loss?
Leucovorin Calcium is not directly associated with affecting weight gain or loss.
Is there a natural alternative to Leucovorin Calcium?
There is no known natural alternative to Leucovorin Calcium that would provide the same protective effects against the toxic effects of certain chemotherapy medicines.
Is Leucovorin Calcium a steroid?
No, Leucovorin Calcium is not a steroid.
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