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Lopinavir + Ritonavir

Uses of Lopinavir + Ritonavir

  • Lopinavir + Ritonavir is primarily used in managing HIV-1 infection, along with other antiretroviral agents.

Side effects of Lopinavir + Ritonavir

  • Diarrhoea

  • Nausea and vomiting

  • Abdominal pain

  • Fatigue (Asthenia)

  • Headache

How Lopinavir + Ritonavir works

  • Lopinavir + Ritonavir is an antiretroviral combination.

  • Lopinavir is a protease inhibitor. It works by blocking the action of HIV-1 protease, an enzyme that plays a vital role in making new virus particles. By blocking this enzyme, lopinavir prevents the virus from multiplying in your body.

  • Ritonavir also belongs to the protease inhibitor class. However, its main function in this combination is to enhance the effectiveness of lopinavir. It does this by inhibiting an enzyme called CYP3A4, which is responsible for breaking down lopinavir in your body. As a result, ritonavir increases the amount of lopinavir in your bloodstream, making it more effective in controlling the HIV virus.

  • Together, these medicines play a crucial role in managing HIV-1 infection by decreasing the number of HIV cells in your body, thereby improving your immune system.

Certified content

Written By

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Dr. Osama AhmedDental/Medical Writer, Editor, Reviewer| 2 years

Bachelor of Dental Surgery

Reviewed By

Dr. Michelle Frank
Dr. Michelle FrankMedical Content Writer| 8 years

Doctor of Medicine

Expert Advice

Dosage Forms Available

  • Lopinavir + Ritonavir is available in the form of tablets and a solution that can be orally administered.

Age and Dose Restrictions

  • This medication is intended for adults and paediatric patients who are 14 days old and above.

Contraindications

  • Lopinavir + Ritonavir is contraindicated in patients with known hypersensitivity to any ingredients in the medication.

Other Medications to Avoid

  • Lopinavir + Ritonavir may interact with certain drugs known as potent CYP3A inducers. These include medications such as herbal products (like St. John's wort), antifungal agents (like ketoconazole and itraconazole), and calcium channel blockers (like diltiazem and amlodipine).

  • This medication may also interact with other antiretroviral agents (like abacavir, dolutegravir, and lamivudine) used to manage HIV infection; therefore, consultation with a doctor is crucial before starting any new medications.

Overdose and Missed Dose

  • Overdosing on Lopinavir + Ritonavir may lead to increased severity of side effects such as diarrhoea, nausea, abdominal pain, and headache. If you suspect an overdose, please consult your doctor immediately.

  • If you miss a dose of Lopinavir + Ritonavir, take it as soon as you remember. But if it is close to the time for your next dose, skip the missed one and continue with your regular routine.

Management of Side Effects

  • Most side effects are temporary and generally harmless and resolve upon discontinuing this medicine. However, if you experience any severe side effects or worsening of any symptoms, please consult your doctor.

  • Drinking plenty of fluids may help manage diarrhoea.

  • Resting or lying down can help manage headaches.

  • Eating smaller meals more often can help control nausea.

Use in Driving and Operating Machinery

  • Dizziness or fatigue may occur while taking Lopinavir + Ritonavir, which might affect your ability to drive or operate machinery. If you feel drowsy or dizzy, avoid these activities.

Use in Pregnancy and Lactation

  • It is best to consult your doctor before starting or continuing the use of Lopinavir + Ritonavir during pregnancy or breastfeeding.

Caution in Other Conditions

  • Patients with pre-existing liver conditions, alcoholism, or hepatitis B or C infection, or haemophilia should use Lopinavir + Ritonavir with caution.

Special Dietary and Lifestyle Recommendations

  • Consuming a healthy diet rich in fruits, vegetables, lean proteins, whole grains, and healthy fats may support overall health and immunity.

  • Regular, moderate physical activity can also help boost the immune system.

  • Avoid smoking and limit alcohol consumption as these can affect your immune system negatively and may worsen the condition.

Frequently asked questions

No, Lopinavir + Ritonavir is not a steroid. It is a combination antiretroviral medication used in the management of HIV-1 infection.

The medicine may cause insomnia in some patients as one of the potential side effects. However, this does not occur with everyone, and the severity may vary between individuals.

There is no explicit information from the research data indicating that Lopinavir + Ritonavir directly affects fertility. However, any concerns regarding fertility should be discussed with your doctor before starting the medicine.

Lopinavir + Ritonavir should be taken with food to enhance absorption. There are no specific dietary restrictions mentioned in the provided data, but if you have concerns or specific dietary requirements, consult your doctor.

Yes, it is safe to take Lopinavir + Ritonavir as recommended by your doctor. The medicine is intended for long-term use to manage HIV-1 infection.

Lopinavir + Ritonavir starts working soon after intake; however, as it is an antiretroviral medication, the beneficial effects in terms of controlling HIV-1 may take some time to become noticeable.

The medicine is taken as directed by your doctor. It is advisable to take it at the same time each day to maintain a consistent level of the medicine in your body.

Terms & Conditions


Lopinavir + Ritonavir in other salts

Available medicines for LOPINAVIR + RITONAVIR
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