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Megestrol

Uses of Megestrol

  • The primary use of Megestrol is in managing advanced breast and endometrial cancers. It belongs to a class of medicines known as progestins.

  • Its secondary uses include improving appetite and inducing weight gain in patients with conditions causing cachexia, including cancer and AIDS.

Side effects of Megestrol

  • Vomiting

  • Diarrhoea

  • Impotence in males

  • Hypertension

  • Rash

How Megestrol works

  • Megestrol is a progestin, a synthetic variant of the hormone progesterone.

  • It functions by inhibiting the pituitary-gonadal axis, reducing oestrogen levels. Oestrogen is a hormone that certain breast and endometrial cancers require for growth. Thus, the decrease in oestrogen levels can help manage these cancers.

Certified content

Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Divya Chauhan
Dr. Divya Chauhan Medical Writer & Reviewer| 6 years

BAMS, APG, PG

Expert Advice

Dosage Forms Available

  • Megestrol comes in oral dosage forms, mainly as tablets and oral suspensions.

Age And Dose Restrictions

  • Megestrol is mainly prescribed to adults.

  • Its use in children has not been established, so it is generally not recommended for paediatric use.

Contraindications

  • Megestrol should not be taken by individuals who have a known hypersensitivity or allergy to megestrol or any of its components.

Other Medications To Avoid With This Medicine

  • Megestrol may interact with HIV protease inhibitors (such as indinavir) and appetite stimulants (like neuropeptide Y).

Overdose And Missed Dose

  • Overdosing on Megestrol can potentially cause symptoms such as diarrhoea, nausea, abdominal pain, cough, unsteady gait, and listlessness. In case of a suspected overdose, immediate medical attention should be sought.

  • If a dose is missed, it should be taken as soon as it is remembered. However, if it is close to the time for the next dose, the missed dose should be skipped, and the regular schedule should be continued. Doubling the dose to make up for the missed one should be avoided.

Management Of Side Effects

Taking the medication with food may help manage gastrointestinal side effects like nausea and diarrhoea.

  • Drinking plenty of fluids can help with symptoms of dry mouth.

  • Regular rest and relaxation techniques may help manage insomnia.

Use In Driving And Operating Machinery

  • Megestrol may cause side effects such as dizziness or confusion, which could affect the ability to drive or operate machinery. It is recommended to avoid these activities if such effects are experienced.

Use In Pregnancy And Lactation

  • Megestrol is not recommended for use during pregnancy due to potential harm to the foetus.

  • The use of this medicine during breastfeeding should also be avoided unless deemed necessary by a doctor.

Caution In Other Conditions

  • Caution is advised when using Megestrol in patients with a history of blood clots or thromboembolic disease.

  • Patients with pre-existing diabetes should also exercise caution due to the risk of high blood sugar from using this medicine.

Special Dietary And Lifestyle Recommendation

  • Regular, balanced meals can help improve general health and well-being, especially in individuals with cachexia (wasting syndrome).

  • Physical activity can promote overall health, stimulate appetite, and help manage weight.

  • Adequate hydration is essential when managing conditions like cancer or AIDS.

Frequently asked questions

Yes, Megestrol is a synthetic derivative of the hormone progesterone. It is a type of steroid medicine.

Megestrol may cause insomnia in some patients, which is difficulty in falling asleep or staying asleep.

Megestrol may have potential impacts on fertility, particularly in women, as it can cause breakthrough uterine bleeding. Please consult your doctor for detailed information.

Megestrol is typically safe to take daily when administered under the supervision of a doctor and following the recommended dosage.

The time taken for Megestrol to work can vary from patient to patient. Therefore, please consult your doctor for precise information.

The best time to take Megestrol varies based on its intended use and your personal health circumstances. Always take this medication as advised by your doctor.

Megestrol is typically available only on prescription and not over the counter.

Terms & Conditions

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