Melphalan

Dosage Forms Available

• This medicine can be taken orally in the form of tablets.

• It is also available as an injectable solution and powder, which is administered through the intravenous route by a healthcare professional.

Age and Dose Restrictions

• It is intended for use in adults over the age of 18.

Contraindications

• Melphalan is contraindicated in patients with a known allergy to it.

• It should not be given to patients who have severely depressed bone marrow function.

Other Medications to Avoid

• It may interact with antibiotics (such as nalidixic acid), immunosuppressants (such as cyclosporine), and antacids (like cimetidine).

Overdose and Missed Dose

• An overdose may cause severe nausea, vomiting, diarrhoea, mouth sores, and dangerously low blood cell counts. If you observe these symptoms, inform your doctor immediately.

• If you miss a dose, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose. Do not take a double dose to make up for a missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• Drinking plenty of water may help to manage some of the side effects like nausea and vomiting.

• Taking the medicine with food might reduce the severity of gut-related side effects, like diarrhoea.

Use in Driving and Operating Machinery

• This medicine can cause side effects such as dizziness and tiredness, which may affect your ability to drive or operate heavy machinery. Avoid these activities if you feel unwell.

Use in Pregnancy and Lactation

• It is recommended to consult a doctor before using this medicine during pregnancy or breastfeeding as it may harm the baby.

Caution in Other Conditions

• Patients with liver or kidney disease should exercise caution when taking this medicine.

• Those with a history of radiation therapy should also be cautious.

Special Dietary and Lifestyle Recommendations

• Maintain a balanced diet to help manage the side effects and support your general health during cancer treatment.

• Regular gentle exercise, such as walking or yoga, can help boost energy levels and manage fatigue associated with this medicine.

• Avoiding exposure to sunlight or wearing protective clothing outdoors can help prevent skin reactions to the medicine.