Mephentermine

Dosage Forms Available

• Mephentermine is available as an injectable solution. It is administered either intramuscularly or by slow intravenous infusion.

Age and Dose Restrictions

• Mephentermine is meant for use in adults only.

Contraindications

• Mephentermine is contraindicated in individuals with tachyarrhythmias or ventricular arrhythmias, severe coronary artery disease, and angle-closure glaucoma. It should not be used during cyclopropane or halogenated anaesthesia.

Other Medications to Avoid

• This medicine may interact with monoamine oxidase inhibitors (such as phenelzine and tranylcypromine), tricyclic antidepressants (like amitriptyline, and clomipramine), ergot alkaloids (such as ergotamine), and oxytocic medicines (like oxytocin).

Overdose and Missed Dose

• Symptoms of overdose include hypertensive crisis, cerebrovascular accidents, myocardial ischemia, psychosis, and seizures. Immediate medical intervention is crucial.

• If a dose of Mephentermine is missed, administer as soon as remembered but avoid doubling the dosage. Regular scheduling should be resumed thereafter.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• Adjust the timing of medication to avoid insomnia if it causes restlessness or sleep disturbances when administered late in the day.

• If experiencing dizziness, ensure adequate hydration by drinking water regularly.

Use in Driving and Operating Machinery

• Mephentermine may affect abilities to drive or operate heavy machinery due to potential side effects like dizziness or restlessness. Caution is advised.

Use in Pregnancy and Lactation

• Mephentermine is not recommended during pregnancy and lactation unless explicitly advised by a doctor. Consult your doctor for guidance before use if you are pregnant or breastfeeding.

Caution in Other Conditions

• Individuals with severe renal impairment or those with a history of psychiatric disorders should use Mephentermine with caution.

• Care should also be exercised in geriatric patients due to increased sensitivity to the medicine's effects.

Special Dietary and Lifestyle Recommendations

• Avoid tyramine-rich foods such as aged cheeses, smoked or cured meats, and certain alcoholic beverages to prevent hypertensive crises.

• Maintain adequate hydration especially if experiencing side effects such as sweating or nausea.

• Engage in stress reduction techniques like meditation or gentle yoga to manage symptoms of restlessness or anxiety induced by Mephentermine.

• Ensure a well-balanced diet to support overall health and recovery, particularly if recovering from conditions that required the use of Mephentermine.