Metformin + Nateglinide

Dosage Forms Available

• Metformin + Nateglinide is available in the form of tablets that are to be taken orally.

Age and Dose Restrictions

• This medicine is intended for use by adults only. It is not recommended for children or adolescents.

Contraindications

• Metformin + Nateglinide is contraindicated in individuals with Type 1 diabetes, diabetic ketoacidosis, severe kidney impairment (eGFR below 30 mL/min/1.73 m²), and known hypersensitivity to either metformin or nateglinide.

Other Medications to Avoid

• This combination may interact with thiazide diuretics (such as hydrochlorothiazide), corticosteroids (like prednisone), phenothiazines (including chlorpromazine), thyroid products (such as levothyroxine), oestrogens (like estradiol), oral contraceptives (including ethinylestradiol), calcium channel blockers (such as amlodipine) and beta-blockers (like propranolol).

Overdose and Missed Dose

• An overdose of Metformin + Nateglinide might lead to severe hypoglycemia characterised by extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure. Immediate medical attention is necessary if overdose is suspected.

• If you miss a dose of Metformin + Nateglinide, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• To manage nausea or an upset stomach, consider taking your medication with food or after meals.

• If experiencing diarrhoea, drink plenty of fluids to stay hydrated.

Use in Driving and Operating Machinery

• Metformin + Nateglinide may cause dizziness or lightheadedness. It is advisable not to drive or operate heavy machinery until you know how this medication affects you.

Use in Pregnancy and Lactation

• The safety of using Metformin + Nateglinide during pregnancy or while breastfeeding has not been fully established. Consult your doctor before using this medication if you are pregnant or breastfeeding.

Caution in Other Conditions

Special caution should be exercised when using Metformin + Nateglinide for individuals with:

• Kidney disease or reduced kidney function

• Liver problems

• Congestive heart failure requiring medication

• Those who consume alcohol excessively

Special Dietary and Lifestyle Recommendations

• Follow a balanced diet rich in fruits, vegetables, whole grains, and lean proteins to help manage blood sugar levels.

• Limit intake of high-sugar and high-fat foods to prevent spikes in blood sugar.

• Engage in regular physical activity such as walking, cycling, or swimming for at least 150 minutes per week to improve blood sugar control and overall health.

• Monitor blood sugar levels regularly as advised by your doctor to ensure effective management of diabetes.

• Avoid skipping meals to help stabilise blood sugar levels throughout the day.