Metformin + Pioglitazone

Dosage Forms Available

• Metformin + Pioglitazone is available for oral administration as tablets.

Age and Dose Restrictions

• This medicine is meant for adults.

Contraindications

• This medicine is contraindicated in individuals with hypersensitivity towards its components and patients with type 1 diabetes, diabetic ketoacidosis, and severe renal impairment (eGFR below 30 mL/min/1.73 m2).

Other Medications to Avoid

• This combination may interact with cationic medications eliminated by renal tubular secretion (such as amiloride, digoxin, morphine), CYP2C8 inhibitors (for example, gemfibrozil), CYP2C8 inducers (like rifampin), and other medications like topiramate.

Overdose and Missed Dose

• An overdose may lead to severe side effects such as lactic acidosis or exacerbation of heart failure. Immediate medical attention is required in such cases.
• If you miss a dose of this medication, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience severe side effects or worsening symptoms, please consult your doctor.

• To manage minor nausea or diarrhoea, consider taking this medicine with food.
• Staying hydrated can help offset mild dehydration symptoms from diarrhoea.

Use in Driving and Operating Machinery

• This medication should not generally affect your ability to drive or operate machinery. However, if you experience side effects that could impair your ability to perform these tasks safely, such as dizziness or fatigue, avoid these activities until better.

Use in Pregnancy and Lactation

• Consult a doctor before using Metformin + Pioglitazone during pregnancy and breastfeeding.

Caution in Other Conditions

• Caution should be exercised when using this medicine in patients with mild to moderate renal impairment, liver disease, heart conditions such as congestive heart failure, and a history of bladder cancer or risk factors for bladder cancer.

Special Dietary and Lifestyle Recommendations

• Maintain a balanced diet low in simple sugars and high in fibre to help manage blood sugar levels.
• Regular physical activity such as brisk walking or swimming for at least 30 minutes most days can enhance glucose control.
• Monitor blood sugar levels regularly as directed by your doctor to ensure the medication is effectively managing your condition.
• Stay hydrated by drinking sufficient water daily, which can help mitigate some side effects like dehydration from diarrhoea.
• Limit consumption of alcohol as it can interfere with blood sugar control and potentially exacerbate medication side effects.