Metformin + Saxagliptin

Dosage Forms Available

• Metformin + Saxagliptin is available as an oral combination in the form of a tablet.

Age and Dose Restrictions

• This combination is intended for use in adults only.

Contraindications

• Metformin + Saxagliptin is contraindicated for patients with severe renal impairment.

• It should not be used by those with acute or chronic metabolic acidosis, including diabetic ketoacidosis.

• Individuals with a history of significant hypersensitivity reactions to either of the components should avoid this medication.

• Patients with hepatic impairment are also advised against using this combination.

Other Medications to Avoid

• This combination may interact with strong inhibitors of CYP3A4/5 enzymes (such as ketoconazole), strong inducers of CYP3A4/5 (such as rifampin), and cationic medicines that are eliminated by renal tubular secretion (such as digoxin, procainamide, and vancomycin).

Overdose and Missed Dose

• In cases of overdose, patients might experience symptoms such as nausea, vomiting, diarrhea, abdominal pain, or lactic acidosis. Immediate medical attention should be sought if an overdose is suspected.

• If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dose schedule. Do not take a double dose to make up for a missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this combination. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• To manage gastrointestinal side effects such as nausea or diarrhea, consider taking it with meals.

• Drinking plenty of water may help alleviate dehydration risks associated with this combination.

Use in Driving and Operating Machinery

• Metformin + Saxagliptin may cause dizziness or fatigue in some individuals. If you experience these symptoms, it is advised to avoid driving or operating heavy machinery until you know how this medication affects you.

Use in Pregnancy and Lactation

• The safety of this combination in pregnant women has not been established. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus.

• It is unknown whether Saxagliptin is excreted in human milk; however, metformin does appear in low concentrations. Consult your doctor before using this medicine during breastfeeding.

Caution in Other Conditions

• Patients with a history of pancreatitis should also use this combination cautiously.

Special Dietary and Lifestyle Recommendations

• Adhering to a balanced diet low in simple sugars and high in fiber can enhance the effectiveness of Metformin + Saxagliptin in managing type 2 diabetes.

• Monitoring carbohydrate intake and maintaining a consistent meal schedule can prevent spikes in blood sugar levels.

• Regular monitoring of blood sugar levels, as recommended by your doctor will help tailor dietary choices and lifestyle habits accordingly.