Mexiletine

Dosage Forms Available

• Mexiletine is available for use via oral route (capsules).

Age and Dose Restrictions

• Mexiletine is generally prescribed for adults of age above 18 years.

Contraindications

• Mexiletine is contraindicated in patients with second or third-degree heart block (unless they have a pacemaker).

• This medicine should not be used by individuals who are hypersensitive to Mexiletine or any of its components.

• Patients with cardiogenic shock should not take this medicine.

Other Medications to Avoid

• Mexiletine may interact with other antiarrhythmic agents (such as quinidine, procainamide and disopyramide), beta-blockers (such as propranolol and metoprolol) and CYP2D6 inhibitors (such as fluoxetine and paroxetine).

Overdose and Missed Dose

• An overdose of Mexiletine may cause severe cardiovascular effects like hypotension, bradycardia, and conduction disturbances. Neurological and gastrointestinal effects may also occur. Immediate medical attention is required in case of an overdose.

• If you miss a dose of Mexiletine, take it as soon as you remember. However, if it is close to the time for your next dose, skip it and continue with your regular schedule. Do not double up on doses.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• Taking Mexiletine with food or an antacid can help minimise gastrointestinal side effects like nausea, vomiting, and heartburn.

• Avoid rising abruptly from a sitting or lying position to prevent dizziness and lightheadedness.

Use in Driving and Operating Machinery

• Mexiletine may cause dizziness, lightheadedness, and impaired coordination. If you feel these effects, it is advised not to drive or operate heavy machinery.

Use in Pregnancy and Lactation

• It is advised to consult your doctor before using this medication if you are pregnant, planning for pregnancy, or breastfeeding.

Caution in Other Conditions

• Patients with pre-existing liver or kidney disease should exercise caution when taking Mexiletine as it is metabolised by the liver and excreted by the kidneys.

Special Dietary and Lifestyle Recommendations

• Maintain a healthy heart-friendly diet. Include more whole grains, fruits, vegetables, lean proteins, and low-fat dairy products in your meals.

• Limit the intake of saturated fats, trans fats, cholesterol, sodium (salt), and added sugars.

• Regular moderate physical activity can help maintain a healthy heart. However, contact your doctor before starting a new exercise regime.