Mirabegron + Solifenacin

Dosage Forms Available

• Mirabegron + Solifenacin comes in the form of extended-release (tablets).

Age and Dose Restrictions

• Mirabegron + Solifenacin is intended for use in adults only. It is not recommended for individuals under 18 years of age due to a lack of studies on safety and efficacy in this age group.

Contraindications

• This medicine is contraindicated in individuals with known hypersensitivity to either mirabegron or solifenacin, as well as any of the excipients found in the tablets.
• It is also contraindicated in patients with end-stage kidney disease or severe hepatic impairment, gastric retention, and uncontrolled narrow-angle glaucoma.

Other Medications to Avoid

• This combination may interact with CYP2D6 enzyme substrates (such as thioridazine, flecainide, propafenone, metoprolol, and desipramine), antimuscarinic medications (such as oxybutynin, and tolterodine), and heart medications (digoxin).

Overdose and Missed Dose

• In case of an overdose of Mirabegron + Solifenacin, medical attention should be sought immediately. Symptoms may include increased heart rate and severe dizziness.
• If you miss a dose, take it as soon as you remember. If it is nearly time for your next dose, skip the missed dose and return to your normal dosage schedule. Do not double up doses to make up for a missed one.

Management of Side Effects

Most side effects of Mirabegron + Solifenacin are temporary and will subside after discontinuing the medication. However, if side effects persist or worsen, consult your doctor.

• Drinking plenty of water can help to manage constipation and dry mouth.
• Rest and relaxation techniques can help manage dizziness and fatigue.

Use in Driving and Operating Machinery

• Mirabegron + Solifenacin may cause dizziness. If this occurs, avoid driving or operating heavy machinery until you are sure you can perform these activities safely.

Use in Pregnancy and Lactation

• It is recommended to consult with your doctor before taking Mirabegron + Solifenacin if you are pregnant, planning to become pregnant, or breastfeeding. The effects of this medicine on the unborn baby are not well studied.

Caution in Other Conditions

• Individuals with severe uncontrolled hypertension should exercise caution when taking this medicine. Also, patients with clinically significant bladder outlet obstruction, severe renal impairment or moderate hepatic impairment should consult their doctor before starting treatment.

Special Dietary and Lifestyle Recommendations

• Regularly practising bladder training exercises can help manage symptoms of overactive bladder.
• Reducing intake of diuretic substances such as caffeine and alcohol can also help manage symptoms.
• Keeping a bladder diary can aid in understanding triggers for urinary urgency and frequency.