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Misoprostol

Uses of Misoprostol

  • Misoprostol is a prostaglandin medication used to prevent stomach ulcers in patients taking NSAIDs by reducing acid production and protecting the stomach. 
  • It is also used for medical abortion (with mifepristone), cervical ripening before uterine procedures, induction of labor, prevention of postpartum hemorrhage, and treatment of NSAID-induced gastric ulcers.

Side effects of Misoprostol

  • Nausea

  • Vomiting

  • Diarrhoea

  • Abdominal pain and cramping

  • Headache

How Misoprostol works

  • Misoprostol is classified as a prostaglandin analogue with gastroprotective and gynaecological actions.

  • It works by binding to myometrial cells' prostaglandin receptors in the uterus, leading to contractions. This action is utilised for inducing labour, medical termination of pregnancy, and managing postpartum haemorrhage. In the case of cervical ripening, Misoprostol aids in breaking down collagen, which helps soften the cervix before certain uterine procedures. For gastric protection, Misoprostol acts by inhibiting the acid secretion and increasing the production of protective mucus in the stomach. This helps to prevent and manage gastric ulcers, particularly those induced by nonsteroidal anti-inflammatory medicines (NSAIDs).

Certified content

Written By

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Dr. Michelle FrankMedical Content Writer| 8 years

Doctor of Medicine

Reviewed By

Dr. Divya Chauhan
Dr. Divya Chauhan Medical Writer & Reviewer| 6 years

BAMS, APG, PG

Expert Advice

Dosage Forms Available

  • Misoprostol can be taken orally (tablet form) or vaginal (suppository) route.

Age and Dose Restrictions

  • Misoprostol is intended for use in adults only.

Contraindications

  • Misoprostol is contraindicated in individuals who are hypersensitive or allergic to misoprostol or any prostaglandins. It should also not be used by patients suffering from inflammatory bowel disease.

Other Medications to Avoid

  • Misoprostol may interact with NSAIDs (e.g., aspirin, ibuprofen) and antacids containing magnesium (e.g., milk of magnesia).

Overdose and Missed Dose

  • Overdose of Misoprostol may lead to severe gastrointestinal distress, excessive uterine cramping, and bleeding. If these symptoms occur, you must seek immediate medical attention.

  • In case you miss a dose of Misoprostol, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • For nausea or vomiting, try taking the medicine with food.

  • In case of diarrhoea, ensure you stay hydrated by drinking plenty of fluids.

  • If you experience dizziness or a headache, rest and avoid sudden movements.

Use in Driving and Operating Machinery

  • Misoprostol may cause dizziness or a headache. If you experience these side effects, do not drive or operate heavy machinery until you feel well enough.

Use in Pregnancy and Lactation

  • Misoprostol is not recommended for use during pregnancy except when used for medical termination of pregnancy. The medicine is excreted in breast milk and should be used cautiously if breastfeeding. Consult your doctor before use.

Caution in Other Conditions

  • Patients with cardiovascular disease should exercise caution when taking Misoprostol. It should also be used cautiously in patients with hepatic or renal impairment, anaemia, diabetes or a history of ectopic pregnancy.

Special Dietary and Lifestyle Recommendations

  • Foods and drinks high in acidity (like citrus fruits, tomatoes, and caffeinated beverages) can aggravate gastrointestinal discomfort. Choose low-acid options to reduce irritation.

  • Drink clear fluids such as water, oral rehydration solutions, or clear broths to maintain hydration.

  • Regular check-ups with your doctor are recommended to monitor your condition.

Frequently asked questions

Misoprostol can affect mood, causing temporary anxiety, irritability, or depression in some individuals, which typically resolves after discontinuation of the medication. Consult your doctor if they persist or worsen.

No, Misoprostol use does not typically affect fertility. However, it is essential to consult your doctor before using it if you plan to conceive soon.

Take Misoprostol as directed by your doctor. Long-term use can cause side effects and should only be done under your doctor's recommendation.

The time Misoprostol takes to show effects varies by condition for which it is being used. Your doctor will be able to provide more accurate information specific to your condition and dosage.

The best time to take Misoprostol is as directed by your doctor, usually at regular intervals throughout the day.

Misoprostol requires a prescription and is not available over the counter.

The duration of treatment with Misoprostol varies depending on the condition being managed and individual patient response.

Terms & Conditions


Available medicines for MISOPROSTOL
Misoprost 200 Tablet 4
Misoprost 200 Tablet 4
Cipla Ltd.
Pack of 4 Units
₹60.02
MRP ₹73.19
18.00% OFF
Misoprost 600 MCG Tablet 1
Misoprost 600 MCG Tablet 1
Cipla Ltd.
Pack of 1 Units
₹67.65
MRP ₹82.50
18.00% OFF
Misogest 200 MCG Tablet 10
Misogest 200 MCG Tablet 10
Elder Pharmaceuticals Ltd
Pack of 10 Units
₹63.07
MRP ₹76.92
18.01% OFF
Cytoheal 200 Tablet 10
Cytoheal 200 Tablet 10
Healing Pharma
Pack of 10 Units
₹143.91
MRP ₹175.50
18.00% OFF
Cytolog 25 MG Tablet 8
Cytolog 25 MG Tablet 8
Zydus Cadila
Pack of 8 Units
₹38.22
MRP ₹76.60
50.10% OFF
Cytolog Tablet 4
Cytolog Tablet 4
Zydus Cadila
Pack of 4 Units
₹57.56
MRP ₹70.20
18.00% OFF
Prestakind 200 MCG Tablet 4
Prestakind 200 MCG Tablet 4
Mankind Pharmaceuticals Ltd.
Pack of 4 Units
₹55.61
MRP ₹67.82
18.00% OFF
Contramax 200mg Tablet 10
Contramax 200mg Tablet 10
Venus Remedies Ltd
Pack of 10 Units
₹39.36
MRP ₹48.00
18.00% OFF

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