Nimesulide + Paracetamol/acetaminophen

Dosage Forms Available

• Nimesulide + Paracetamol/Acetaminophen can be taken orally (tablet and suspension).

Age And Dose Restrictions 

• This combination is intended to be used by adults and children above 12 years. 

Contraindications 

• This combination is contraindicated in patients with a history of hypersensitivity to nimesulide or paracetamol/acetaminophen. It is also contraindicated in patients with active or a history of recurrent peptic ulcers, gastrointestinal bleeding or other bleeding disorders. 

Medications To Avoid With This Drug

• Avoid taking gastric acid reducers (cimetidine), antacids (aluminium hydroxide), antiarrhythmics (digoxin), diuretics (furosemide), anticoagulants (warfarin), immunosuppressive medications (methotrexate), cholesterol-lowering medications (cholestyramine), prokinetic agents (metoclopramide and domperidone), and anticonvulsants (carbamazepine). These medications may alter the safety and effectiveness of Nimesulide + Paracetamol/Acetaminophen.

Overdose And Missed Dose

• Overdose can cause lethargy, drowsiness, nausea, vomiting, and abdominal pain. These symptoms need to be managed as an emergency in a hospital setting. Therefore, strict adherence to the prescribed dose is essential.
• If you miss a dose of this combination, take it as soon as you remember. But, if the next dose is near, skip the missed dose and resume the regular dosing regime.

Management Of Side Effects

• Take this combination with food to reduce gastrointestinal side effects and continue taking it as prescribed. If side effects worsen or persist, consult your doctor for a possible treatment plan adjustment.

Use In Driving And Operating Machinery

• This combination can make you feel dizzy. It is not recommended to drive, operate machinery, or do other activities that require mental alertness or coordination after taking this combination. 

Use In Pregnancy And Lactation

• This combination is not recommended during pregnancy and breastfeeding.

Caution In Other Conditions

• Caution is advised in older adults and patients with heart conditions, severe coagulation disorders and kidney and liver impairment.

Special Dietary And Lifestyle Recommendation

• Avoid alcohol consumption, as it may increase the risk of adverse side effects.
• Take this combination only for the prescribed duration.
• Excess weight can put a strain on joints and exacerbate osteoarthritis pain. Aim to maintain a healthy weight through a balanced diet and regular exercise.
• You may apply a warm compress or ice pack to affected areas to relieve muscle pains.
• Choose comfortable, supportive shoes to minimise the impact on joints and muscles.