Nitazoxanide + Ofloxacin

Dosage Forms Available

• Nitazoxanide + Ofloxacin can be taken orally (tablet).

Age and Dose Restrictions

• This medication is intended for use in adults and children above 12 years of age.

Contraindications

• Nitazoxanide + Ofloxacin should not be used by individuals with known allergies to nitazoxanide, ofloxacin, or other quinolone antibiotics. It is also contraindicated in individuals suffering from hepatic encephalopathy or Clostridium difficile associated diarrhoea, and those with a history of tendon inflammation or rupture. Individuals with known glucose-6-phosphate dehydrogenase (G6PD) deficiency should avoid this medication.

Other Medications to Avoid

• The Nitazoxanide + Ofloxacin combination may interact with highly plasma protein-bound medicines (such as warfarin), multivitamins (such as those containing zinc), antidiabetic agents (like metformin), nonsteroidal anti-inflammatory medicines (such as ibuprofen), and certain antiarrhythmics (like amiodarone).

Overdose and Missed Dose

• Overdosing on Nitazoxanide + Ofloxacin can result in symptoms like nausea, vomiting, epigastric distress, dizziness, and headache. If these symptoms are observed, professional medical help should be sought immediately.

• In case of a missed dose of this medication, it should be taken as soon as one remembers. However, if it is near the time for the next dose, the missed dose should be skipped to prevent doubling up on dosage.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• Drinking plenty of water can help manage diarrhoea and nausea, which are common side effects.

• Rest and relaxation techniques can help manage headache and dizziness.

Use in Driving and Operating Machinery

• Nitazoxanide + Ofloxacin might affect the ability to concentrate, hence caution should be exercised while driving or operating heavy machinery.

Use in Pregnancy and Lactation

• Nitazoxanide + Ofloxacin is not recommended for use during pregnancy and lactation. It is always advised to consult a doctor before using this medicine during these periods.

Caution in Other Conditions

• Patients with kidney failure should exercise caution when taking Nitazoxanide + Ofloxacin as dose adjustments may be needed.

• Individuals with conditions causing QT interval prolongation should also be cautious as this medication could potentially worsen the condition.

Special Dietary and Lifestyle Recommendations

• Maintain good personal hygiene to prevent recurrent infections.

• Maintain proper hydration, especially if suffering from diarrhoea.

• Avoid crowded places and contact with sick individuals to prevent catching infections.