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Norethisterone

Uses of Norethisterone

  • Norethisterone is used to treat heavy, painful, or irregular menstrual periods and belongs to the class of medications called progestins.

  • It is also used to manage endometriosis, amenorrhoea (absence of menstrual periods), and premenstrual syndrome (PMS).

  • It is used as a component of hormonal contraceptives to prevent pregnancy and, in some cases, in the treatment of breast cancer.

Side effects of Norethisterone

  • Irregular vaginal bleeding or spotting

  • Nausea

  • Vomiting

  • Bloating

  • Breast tenderness and enlargement

  • Headaches

  • Dizziness

  • Mood changes

  • Acne

  • Oily skin

  • Hair loss or excessive growth

How Norethisterone works

  • Norethisterone is a synthetic progestin medication.

  • It works by mimicking the activity of the natural hormone progesterone.

  • Norethisterone binds to progesterone receptors in the body and regulates the growth and shedding of the uterine lining (endometrium).

  • By maintaining high progestin levels, norethisterone delays the shedding of the endometrium and the onset of menstruation. This helps in treating various menstrual irregularities and disorders.

Certified content

Written By

docImg
Dr Vatsalya D GhanekarMedical Content Writer| 5 years

MD Ayurveda

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Norethisterone is available as oral tablets, injectable suspensions, and subdermal implants. It is taken orally or administered through intramuscular injections or implants.

Age and Dose Restrictions

  • Norethisterone is typically prescribed for adult women.

Contraindications

  • Norethisterone should be used with caution in patients with liver disease, a history of heart attack, stroke, or blood clots, breast cancer or other hormone-sensitive cancers, undiagnosed abnormal vaginal bleeding, porphyria (a blood disorder), diabetes, hypertension, or high cholesterol.
  • This medicine is contraindicated in pregnant women as it may harm the foetus. It should also be avoided in women with known allergies to norethisterone or any of its components.

Other Medications to Avoid

  • This drug may interact with antiretrovirals (such as ritonavir and efavirenz), antibiotics (like rifabutin and griseofulvin), anticoagulants (such as warfarin), and anti-seizure medications (including topiramate and phenobarbital).
  • Before starting any prescription or over-the-counter medications, it's crucial to consult a doctor.

Overdose and Missed Dose

  • In case of an overdose, contact your doctor immediately or seek emergency medical care if you experience severe symptoms.
  • If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • Nausea and vomiting can often be managed by taking the medication with food. If these symptoms are severe, contact your doctor.

Use in Driving and Operating Machinery

  • Norethisterone may cause dizziness in some people. Before you know how this medicine affects you, exercise caution while driving or operating heavy machinery.

Use in Pregnancy and Lactation

  • Norethisterone is contraindicated in pregnancy as it may cause foetal harm. It should only be used during breastfeeding if the potential benefits outweigh the risks.

Caution in Other Conditions

  • Patients with liver disease should use norethisterone with caution and under close medical supervision.

Special Dietary and Lifestyle Recommendations

  • Maintain a healthy lifestyle with regular exercise and a balanced diet to help manage menstrual and gynaecological disorders.
  • Engage in stress-reducing activities like yoga, meditation, or deep breathing exercises, as stress can sometimes worsen menstrual symptoms.

Frequently asked questions

Yes, norethisterone can be used to postpone menstruation when taken as directed by a doctor.

While norethisterone is a component of some hormonal contraceptives, it is not a standalone contraceptive. Additional non-hormonal methods should be used to prevent pregnancy.

Some women may experience weight gain as a side effect of norethisterone. However, this varies among individuals.

The onset of action depends on the condition being treated. For menstrual disorders, effects may be seen within the first treatment cycle.

Acne is a potential side effect of norethisterone, particularly in the first few months of treatment. If it persists or becomes severe, consult a doctor.

The safety of long-term use should be discussed with your doctor, as it depends on your health condition and medical history.

Yes, norethisterone is sometimes prescribed to manage endometriosis symptoms by suppressing the growth of endometrial tissue.

Terms & Conditions

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