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Olanzapine

Uses of Olanzapine

  • Olanzapine, an atypical antipsychotic, is primarily used to manage schizophrenia and bipolar I disorder in adults and teenagers aged 13 and older. It can also help treat psychosis or agitation related to Alzheimer's dementia, bipolar depression, and treatment-resistant depression (when combined with antidepressants).
  • Additionally, Olanzapine is used for conditions such as Tourette syndrome, delirium, and chemotherapy-induced nausea and vomiting.

Side effects of Olanzapine

  • Postural hypotension (sudden drop in blood pressure on standing)

  • Constipation

  • Dizziness

  • Personality disorder

  • Weight gain

How Olanzapine works

  • Olanzapine is an atypical antipsychotic medicine.

  • Olanzapine primarily acts as an antagonist at dopamine and serotonin receptors. Specifically, it has a high affinity for dopamine D1, D2, D4, 5HT2A, 5HT2C, 5HT6, muscarinic M1-M5, histamine H1, and adrenergic α1 receptors. It works by restoring the balance of certain natural substances in the brain, known as neurotransmitters.

  • Although the exact mechanism of action of Olanzapine in schizophrenia is unknown, it is believed that the medicine's effectiveness in managing schizophrenia is mediated through a combination of dopamine and serotonin type 2 (5HT2) competition. In simple terms, Olanzapine may work by blocking the effects of chemicals associated with most symptoms of schizophrenia.

  • By managing the action of these chemicals in the brain, Olanzapine helps reduce hallucinations, disturbed thoughts, and hostility often associated with psychiatric conditions.

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Dr. Osama AhmedDental/Medical Writer, Editor, Reviewer| 2 years

Bachelor of Dental Surgery

Reviewed By

Ashmita Borgohain
Ashmita BorgohainMedical Content Writer & Editor| 12 years

MSc (Applied Genetics)

Expert Advice

Dosage Forms Available

  • Olanzapine is available in various dosage forms for use via the oral (tablets and orally disintegrating tablets) and intramuscular (intramuscular injection) routes.

Age and Dose Restrictions

  • Olanzapine is primarily meant for adults and patients above 18 years of age.

Contraindications

  • Olanzapine is contraindicated in patients with a known hypersensitivity to Olanzapine or any components in the formulation.

  • Caution should be exercised when prescribing to patients with Alzheimer's disease, Parkinson's disease, and Lewy body dementia due to increased sensitivity to antipsychotics.

Other Medications to Avoid

  • Olanzapine may interact with proton pump inhibitors (e.g., omeprazole), antibiotics (e.g., ciprofloxacin, rifampin), and CNS depressants like benzodiazepines (e.g., clonazepam, diazepam) and opioids (e.g., codeine, oxycodone).

Overdose and Missed Dose

  • An overdose of Olanzapine can cause severe mental changes such as restlessness, hallucinations, or confusion. If you suspect an overdose, seek immediate medical attention.

  • If you miss a dose of Olanzapine, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • For side effects such as constipation or dry mouth, increasing water intake can help.

  • If dizziness occurs, sitting or lying down until the feeling passes can be beneficial.

Use in Driving and Operating Machinery

  • Olanzapine may cause drowsiness and affect your ability to drive or operate heavy machinery. If you feel dizzy or sleepy after taking this medicine, avoid driving or operating machinery.

Use in Pregnancy and Lactation

  • Olanzapine should only be used during pregnancy if the potential benefit to the mother justifies the potential risk to the foetus. This can be discussed with your doctor, who will advise you accordingly.

  • It is not known if Olanzapine is excreted in human breast milk. Consult your doctor before using this medicine during breastfeeding.

Caution in Other Conditions

  • Patients with liver disease should exercise caution when taking Olanzapine as it is metabolised in the liver.

  • Patients with a history of seizures or conditions that lower the seizure threshold should also exercise caution.

Special Dietary and Lifestyle Recommendations

  • Because one of the common side effects of Olanzapine is weight gain, a balanced diet low in processed foods and high in fruits, vegetables, and lean proteins can help manage weight.

  • Regular physical activity can also assist in managing weight gain associated with Olanzapine use.

  • Adequate sleep and stress management techniques such as yoga or meditation may help manage underlying conditions like schizophrenia or bipolar disorder.

Frequently asked questions

No, Olanzapine is not a steroid. It is an atypical antipsychotic medication.

Yes, one of the common side effects of Olanzapine is somnolence, which means it might make you feel drowsy or sleepy.

There are no specific studies about its effect on fertility, but it is always advisable to consult your doctor if you are planning to conceive while taking this medication.

No specific diet restrictions are mentioned in the references. However, a balanced diet always helps in maintaining overall health.

Yes, it is safe to take Olanzapine daily as advised by your doctor. Do not self-medicate, and always follow your doctor's instructions.

Olanzapine reaches peak plasma concentrations within 5 to 8 hours after oral administration. However, the therapeutic effects may take longer to appear.

Although it can be taken at any time of the day, it is generally advised to take it as per your doctor's instructions and preferably at the same time each day for better efficacy.

Terms & Conditions


Olanzapine in other salts

Available medicines for OLANZAPINE
Olet 1.25 MG Tablet 10
Olet 1.25 MG Tablet 10
Alteus Biogenics Pvt.ltd.
Pack of 10 Units
₹22.82
MRP ₹27.83
18.00% OFF
Oliza 5 MG Tablet 10
Oliza 5 MG Tablet 10
Intas Pharmaceuticals Ltd
Pack of 10 Units
₹31.57
MRP ₹38.50
18.00% OFF
Oleanz 2.5 MG Tablet 10
Oleanz 2.5 MG Tablet 10
Sun Pharma Laboratories Ltd.
Pack of 10 Units
₹25.42
MRP ₹31.00
18.00% OFF
Oliza 2.5 MG Tablet 10
Oliza 2.5 MG Tablet 10
Intas Pharmaceuticals Ltd
Pack of 10 Units
₹26.24
MRP ₹32.00
18.00% OFF
Anzip 2.5 MG Tablet Md 10
Anzip 2.5 MG Tablet Md 10
Alde Medi Impex
Pack of 10 Units
₹23.78
MRP ₹29.00
18.00% OFF
Oltha 5 MG Tablet 10
Oltha 5 MG Tablet 10
Shine Pharmaceuticals Ltd
Pack of 10 Units
₹27.55
MRP ₹33.60
18.00% OFF
Oleanz Rapitab 20 MG Tablet 10
Oleanz Rapitab 20 MG Tablet 10
Sun Pharma Laboratories Ltd.
Pack of 10 Units
₹139.40
MRP ₹170.00
18.00% OFF
Olimelt 2.5 MG Tablet 10
Olimelt 2.5 MG Tablet 10
Intas Pharmaceuticals Ltd
Pack of 10 Units
₹26.24
MRP ₹32.00
18.00% OFF

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