Olaparib
Uses of Olaparib
Primarily, Olaparib is used for the management of specific types of ovarian, breast, pancreatic, and prostate cancers in patients with BRCA gene mutations. This medication belongs to a class of medicines known as PARP inhibitors.
Secondary uses of Olaparib include its application as a maintenance treatment for advanced ovarian cancer, fallopian tube cancer, or primary peritoneal cancer in patients who have responded well to first-line platinum-based chemotherapy.
Side effects of Olaparib
Common side effects of Olaparib include:
Anaemia
Nausea and vomiting
Fatigue and weakness
Diarrhea
Loss of appetite
How Olaparib works
Olaparib is a type of anti-cancer medicine known as poly ADP-ribose polymerase (PARP) inhibitors.
It works by blocking the PARP enzyme, which is involved in repairing damaged DNA in cells. In cancer cells, especially those with BRCA mutations, this inhibition prevents the repair of DNA damage, leading to cell death. This helps slow down or stop the growth of cancer cells, particularly in cancers like ovarian and breast cancer with defective DNA repair mechanisms.
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Written By
BDS, MDS
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Olaparib is available for use as a tablet.
This formulation allows for oral administration.
Age and Dose Restrictions
This medicine is meant for use by adults only.
Contraindications
Olaparib is contraindicated in patients with known hypersensitivity to the active substance or any of the excipients.
Other Medications to Avoid
Olaparib may interact with certain medications, including antifungals (such as ketoconazole), antivirals (like ritonavir), antibiotics (such as rifampin), and anticonvulsants (like phenytoin). These interactions can alter how olaparib is processed in the body, potentially increasing side effects or reducing its effectiveness.
Overdose and Missed Dose
In the event of an overdose, there is no specific treatment; general supportive measures and symptomatic treatment are recommended.
If you miss a dose of Olaparib, take your next dose at its scheduled time. Do not take an extra dose to make up for the missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Adjusting the timing of the medication may help manage nausea or fatigue.
Increasing fluid intake can help alleviate issues such as dry mouth or constipation.
Use in Driving and Operating Machinery
Olaparib may cause fatigue and dizziness. It is advisable to avoid driving or operating heavy machinery if you experience these side effects.
Use in Pregnancy and Lactation
Olaparib is not recommended during pregnancy or breastfeeding due to potential risks to the fetus or baby.
Consult your doctor before using this medicine if you are pregnant or breastfeeding.
Caution in Other Conditions
Patients with moderate to severe renal impairment or severe hepatic impairment may require dose adjustments when using Olaparib.
Caution is advised for patients with pre-existing lung conditions due to the risk of pneumonitis.
Special Dietary and Lifestyle Recommendations
Avoid consuming grapefruit or Seville oranges as they can increase blood levels of Olaparib, potentially leading to increased side effects.
Maintain a well-balanced diet to help manage potential side effects like loss of appetite and weight changes.
Opt for small, frequent meals if experiencing nausea.
Engage in light physical activities such as walking to combat fatigue, unless advised otherwise by your doctor.
Stay hydrated especially if experiencing diarrhoea or vomiting to prevent dehydration.
Ensure adequate rest periods to help counteract feelings of fatigue and weakness.
Frequently asked questions
What class of medicine does Olaparib belong to?
Olaparib is an anti-cancer medication that falls under the class of medications known as PARP (poly ADP-ribose polymerase) inhibitors.
Can Olaparib affect my mood or emotions?
There are no specific studies suggesting that Olaparib directly affects mood or emotions. However, like any other medication, side effects such as fatigue and weakness might influence your overall well-being. Always communicate any emotional or psychological changes to your doctor while on this medication.
Is it safe for vegetarians or vegans to take Olaparib?
Yes, Olaparib is safe for vegetarians and vegans. However, if you have any specific dietary concerns or allergies, you should consult your doctor.
How long does Olaparib stay in the body?
Olaparib exhibits an elimination half-life of approximately 12 hours at the 300mg twice-daily dose. This means after 12 hours, approximately half of the medicine is eliminated from the body.
Does Olaparib interact with any food items?
Grapefruit and Seville oranges should not be consumed while on Olaparib as they can increase the amount of the medicine in your blood.
Can I become dependent on Olaparib?
Olaparib is not known to cause dependence or addiction. It is a prescription medication used to manage certain types of cancers and must be used strictly as directed by your doctor.
What are some alternative salts similar to Olaparib?
There are other medicines in the same class as Olaparib, known as PARP inhibitors, which may serve as alternatives. These include Rucaparib and Niraparib amongst others.
List of Medicines for Olaparib
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