Primarily, Olaparib is used for the management of specific types of ovarian, breast, pancreatic, and prostate cancers in patients with BRCA gene mutations. This medication belongs to a class of medicines known as PARP inhibitors.
Secondary uses of Olaparib include its application as a maintenance treatment for advanced ovarian cancer, fallopian tube cancer, or primary peritoneal cancer in patients who have responded well to first-line platinum-based chemotherapy.
Common side effects of Olaparib include:
Anaemia
Nausea and vomiting
Fatigue and weakness
Diarrhea
Loss of appetite
Olaparib is a type of anti-cancer medicine known as poly ADP-ribose polymerase (PARP) inhibitors.
It works by blocking the PARP enzyme, which is involved in repairing damaged DNA in cells. In cancer cells, especially those with BRCA mutations, this inhibition prevents the repair of DNA damage, leading to cell death. This helps slow down or stop the growth of cancer cells, particularly in cancers like ovarian and breast cancer with defective DNA repair mechanisms.
BDS, MDS
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Olaparib is available for use as a tablet.
This formulation allows for oral administration.
This medicine is meant for use by adults only.
Olaparib is contraindicated in patients with known hypersensitivity to the active substance or any of the excipients.
Olaparib may interact with certain medications, including antifungals (such as ketoconazole), antivirals (like ritonavir), antibiotics (such as rifampin), and anticonvulsants (like phenytoin). These interactions can alter how olaparib is processed in the body, potentially increasing side effects or reducing its effectiveness.
In the event of an overdose, there is no specific treatment; general supportive measures and symptomatic treatment are recommended.
If you miss a dose of Olaparib, take your next dose at its scheduled time. Do not take an extra dose to make up for the missed one.
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Adjusting the timing of the medication may help manage nausea or fatigue.
Increasing fluid intake can help alleviate issues such as dry mouth or constipation.
Olaparib may cause fatigue and dizziness. It is advisable to avoid driving or operating heavy machinery if you experience these side effects.
Olaparib is not recommended during pregnancy or breastfeeding due to potential risks to the fetus or baby.
Consult your doctor before using this medicine if you are pregnant or breastfeeding.
Patients with moderate to severe renal impairment or severe hepatic impairment may require dose adjustments when using Olaparib.
Caution is advised for patients with pre-existing lung conditions due to the risk of pneumonitis.
Avoid consuming grapefruit or Seville oranges as they can increase blood levels of Olaparib, potentially leading to increased side effects.
Maintain a well-balanced diet to help manage potential side effects like loss of appetite and weight changes.
Opt for small, frequent meals if experiencing nausea.
Engage in light physical activities such as walking to combat fatigue, unless advised otherwise by your doctor.
Stay hydrated especially if experiencing diarrhoea or vomiting to prevent dehydration.
Ensure adequate rest periods to help counteract feelings of fatigue and weakness.
Frequently asked questions
Olaparib is an anti-cancer medication that falls under the class of medications known as PARP (poly ADP-ribose polymerase) inhibitors.
There are no specific studies suggesting that Olaparib directly affects mood or emotions. However, like any other medication, side effects such as fatigue and weakness might influence your overall well-being. Always communicate any emotional or psychological changes to your doctor while on this medication.
Yes, Olaparib is safe for vegetarians and vegans. However, if you have any specific dietary concerns or allergies, you should consult your doctor.
Olaparib exhibits an elimination half-life of approximately 12 hours at the 300mg twice-daily dose. This means after 12 hours, approximately half of the medicine is eliminated from the body.
Grapefruit and Seville oranges should not be consumed while on Olaparib as they can increase the amount of the medicine in your blood.
Olaparib is not known to cause dependence or addiction. It is a prescription medication used to manage certain types of cancers and must be used strictly as directed by your doctor.
There are other medicines in the same class as Olaparib, known as PARP inhibitors, which may serve as alternatives. These include Rucaparib and Niraparib amongst others.
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