Home/Drugs By Ailments / Olaparib

Olaparib

Uses of Olaparib

  • Primarily, Olaparib is used for the management of specific types of ovarian, breast, pancreatic, and prostate cancers in patients with BRCA gene mutations. This medication belongs to a class of medicines known as PARP inhibitors.

  • Secondary uses of Olaparib include its application as a maintenance treatment for advanced ovarian cancer, fallopian tube cancer, or primary peritoneal cancer in patients who have responded well to first-line platinum-based chemotherapy.

Side effects of Olaparib

Common side effects of Olaparib include:

  • Anaemia

  • Nausea and vomiting

  • Fatigue and weakness

  • Diarrhea

  • Loss of appetite

How Olaparib works

  • Olaparib is a type of anti-cancer medicine known as poly ADP-ribose polymerase (PARP) inhibitors.

  • It works by blocking the PARP enzyme, which is involved in repairing damaged DNA in cells. In cancer cells, especially those with BRCA mutations, this inhibition prevents the repair of DNA damage, leading to cell death. This helps slow down or stop the growth of cancer cells, particularly in cancers like ovarian and breast cancer with defective DNA repair mechanisms.

Certified content

Written By

docImg
Dr Nikita LoboMedical Editor & Reviewer| 8 years

BDS, MDS

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 9 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Olaparib is available for use as a tablet.

  • This formulation allows for oral administration.

Age and Dose Restrictions

  • This medicine is meant for use by adults only.

Contraindications

  • Olaparib is contraindicated in patients with known hypersensitivity to the active substance or any of the excipients.

Other Medications to Avoid

  • Olaparib may interact with certain medications, including antifungals (such as ketoconazole), antivirals (like ritonavir), antibiotics (such as rifampin), and anticonvulsants (like phenytoin). These interactions can alter how olaparib is processed in the body, potentially increasing side effects or reducing its effectiveness.

Overdose and Missed Dose

  • In the event of an overdose, there is no specific treatment; general supportive measures and symptomatic treatment are recommended.

  • If you miss a dose of Olaparib, take your next dose at its scheduled time. Do not take an extra dose to make up for the missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • Adjusting the timing of the medication may help manage nausea or fatigue.

  • Increasing fluid intake can help alleviate issues such as dry mouth or constipation.

Use in Driving and Operating Machinery

  • Olaparib may cause fatigue and dizziness. It is advisable to avoid driving or operating heavy machinery if you experience these side effects.

Use in Pregnancy and Lactation

  • Olaparib is not recommended during pregnancy or breastfeeding due to potential risks to the fetus or baby.

  • Consult your doctor before using this medicine if you are pregnant or breastfeeding.

Caution in Other Conditions

  • Patients with moderate to severe renal impairment or severe hepatic impairment may require dose adjustments when using Olaparib.

  • Caution is advised for patients with pre-existing lung conditions due to the risk of pneumonitis.

Special Dietary and Lifestyle Recommendations

  • Avoid consuming grapefruit or Seville oranges as they can increase blood levels of Olaparib, potentially leading to increased side effects.

  • Maintain a well-balanced diet to help manage potential side effects like loss of appetite and weight changes.

  • Opt for small, frequent meals if experiencing nausea.

  • Engage in light physical activities such as walking to combat fatigue, unless advised otherwise by your doctor.

  • Stay hydrated especially if experiencing diarrhoea or vomiting to prevent dehydration.

  • Ensure adequate rest periods to help counteract feelings of fatigue and weakness.

Frequently asked questions

Olaparib is an anti-cancer medication that falls under the class of medications known as PARP (poly ADP-ribose polymerase) inhibitors.

There are no specific studies suggesting that Olaparib directly affects mood or emotions. However, like any other medication, side effects such as fatigue and weakness might influence your overall well-being. Always communicate any emotional or psychological changes to your doctor while on this medication.

Yes, Olaparib is safe for vegetarians and vegans. However, if you have any specific dietary concerns or allergies, you should consult your doctor.

Olaparib exhibits an elimination half-life of approximately 12 hours at the 300mg twice-daily dose. This means after 12 hours, approximately half of the medicine is eliminated from the body.

Grapefruit and Seville oranges should not be consumed while on Olaparib as they can increase the amount of the medicine in your blood.

Olaparib is not known to cause dependence or addiction. It is a prescription medication used to manage certain types of cancers and must be used strictly as directed by your doctor.

There are other medicines in the same class as Olaparib, known as PARP inhibitors, which may serve as alternatives. These include Rucaparib and Niraparib amongst others.

Terms & Conditions

Available medicines for OLAPARIB
Ribaxa 100mg Tablet 10
Ribaxa 100mg Tablet 10
Dr. Reddys Laboratories Ltd
Pack of 10 Units
₹1333.28
MRP ₹1666.6
20% OFF
Olparib 100mg Tablet 60
Olparib 100mg Tablet 60
Glenmark Pharmaceuticals Ltd.
Pack of 60 Units
₹7193.6
MRP ₹8992
20% OFF
Bracanat 150 Tablet 30
Bracanat 150 Tablet 30
Natco Pharma Ltd
Pack of 30 Units
₹18000
MRP ₹22500
20% OFF
Ribaxa + 100mg Tablet 60
Ribaxa + 100mg Tablet 60
Dr. Reddys Laboratories Ltd
Pack of 60 Units
₹8000
MRP ₹10000
20% OFF
Olparib 150mg Tablet 60
Olparib 150mg Tablet 60
Glenmark Pharmaceuticals Ltd.
Pack of 60 Units
₹10312
MRP ₹12890
20% OFF
Lupiparp 150 Tablet 60
Lupiparp 150 Tablet 60
Lupin Ltd
Pack of 60 Units
₹19520
MRP ₹24400
20% OFF
Ribaxa + 150mg Tablet 60
Ribaxa + 150mg Tablet 60
Dr. Reddys Laboratories Ltd
Pack of 60 Units
₹11200
MRP ₹14000
20% OFF
Lupiparp 100 Tablet 60
Lupiparp 100 Tablet 60
Lupin Ltd
Pack of 60 Units
₹14000
MRP ₹17500
20% OFF

Subscribe

Claim your complimentary health and fitness tips subscription and stay updated on our newest promotions.

Registered Office Address

Intellihealth Solutions Private Limited
Office Unit no. 1, 2, 5, & 7, 6th floor Urmi Corporate Park Solaris, Saki Vihar Rd, Opp. L&T Flyover, New Mhada Colony, Budhia Jadhav Wadi, Mumbai, Maharashtra 400072.
CIN: U85320MH2019PTC320566
Telephone:09240250346

Grievance Officer

Name: Chandrasekhar Swaminathan

Download Truemeds

Manage your health with ease Download Truemeds today!Get easy access to medicine refills, health information, and more. With our app, you'll never have to wait in line again. Download now and start taking control of your health.
playstoreIcon

Contact Us

Our customer representative team is available 7 days a week from 9 am - 9 pm.


v3.7.0

copyright2025 - Truemeds | All rights reserved

Our Payment Partners

paymentPartnerpaymentPartnerpaymentPartnerpaymentPartnerpaymentPartner
paymentPartnerpaymentPartnerpaymentPartnerpaymentPartner