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Ondansetron + Ranitidine

Uses of Ondansetron + Ranitidine

  • The primary use of Ondansetron + Ranitidine is to prevent and manage nausea and vomiting associated with cancer chemotherapy, radiation therapy, and surgery. This combination belongs to the class of serotonin 5-HT3 receptor antagonists and histamine-2 (H2) blockers.
  • It also helps in managing symptoms of indigestion and acid reflux that could worsen nausea.

Side effects of Ondansetron + Ranitidine

  • Headache

  • Constipation or diarrhoea

  • Fatigue or weakness

  • Drowsiness

  • Dry mouth

How Ondansetron + Ranitidine works

  • Ondansetron + Ranitidine is a combination of a serotonin 5-HT3 receptor antagonist and a histamine-2 (H2) blocker.
  • Ondansetron works by selectively blocking serotonin 5-HT3 receptors in the brain and in the stomach. This action prevents serotonin, a natural substance in the body, from sending signals that can cause feelings of nausea and vomiting.
  • Ranitidine, on the other hand, works by blocking the action of histamine on H2 receptors in the stomach. This decreases the production of stomach acid, which can help prevent acid reflux and alleviate symptoms of indigestion that can worsen feelings of nausea.

Certified content

Written By

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Dr. Michelle FrankMedical Content Writer| 8 years

Doctor of Medicine

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Ondansetron + Ranitidine is available as oral tablets and orally disintegrating tablets for use via oral route.
  • It is also accessible as an oral solution, which is also taken orally.

Age and Dose Restrictions

  • The combination of Ondansetron + Ranitidine is intended for use in adults.
  • It is not recommended for use in children unless advised otherwise by a doctor.

Contraindications

  • Ondansetron + Ranitidine should not be used in patients with a known hypersensitivity to either of the active ingredients.
  • This combination is contraindicated in patients who are taking apomorphine due to the risk of profound hypotension and loss of consciousness.

Other Medications to Avoid

  • This combination may interact with medications such as apomorphine (risk of severe hypotension and loss of consciousness), tramadol (reduction in analgesic effect), selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) (increased risk of serotonin syndrome), QT-prolonging medicines (e.g., quinidine, procainamide, amiodarone - increased risk of QT prolongation and arrhythmias), and anticholinergic medications (additive effects may worsen constipation and drowsiness).
  • Before starting any new medications, ensure to consult your doctor.

Overdose and Missed Dose

  • An overdose of Ondansetron + Ranitidine may result in severe effects like irregular heartbeat, seizures, or blurred vision. If you suspect an overdose, seek immediate medical attention.
  • If you miss a dose, take it as soon as you remember. However, if it is almost time for the next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take extra medicine to make up for the missed dose.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • Drinking plenty of water can help manage constipation.
  • Rest and avoid strenuous activities if you experience fatigue or weakness.
  • Suck on sugar-free hard candy or chew sugar-free gum to manage dry mouth.

Use in Driving and Operating Machinery

  • Ondansetron + Ranitidine may cause drowsiness or tiredness. If you feel drowsy or tired after taking this medicine, avoid driving or operating heavy machinery.

Use in Pregnancy and Lactation

  • Consult your doctor before using this Ondansetron + Ranitidine during pregnancy and breastfeeding.

Caution in Other Conditions

  • Patients with liver disease, heart problems, or electrolyte imbalances should exercise caution when using Ondansetron + Ranitidine.
  • Ondansetron may prolong the QT interval and should be used carefully in patients with congenital long QT syndrome or other heart rhythm disorders.

Special Dietary and Lifestyle Recommendations

  • Maintain a balanced diet rich in fruits, vegetables, whole grains, lean proteins, and healthy fats to support overall health.
  • Stay hydrated by drinking plenty of water throughout the day.
  • Adopt a regular exercise routine to maintain physical health and well-being.
  • Avoid alcohol as it can worsen side effects like drowsiness and may irritate the stomach lining.

Frequently asked questions

Though it is uncommon, some patients may experience mood changes while taking Ondansetron + Ranitidine. If you notice any significant mood swings or behavioural changes, please consult your doctor.

There is no significant evidence to suggest that Ondansetron + Ranitidine directly impacts the menstrual cycle. However, if you notice any changes in your cycle while taking this medicine, please discuss it with your doctor.

Some patients might experience changes in appetite while taking Ondansetron + Ranitidine. If there are significant changes in your eating habits or weight, please consult your doctor.

Ondansetron + Ranitidine does not typically affect the hormones in the body. However, if you observe any unexplained symptoms related to hormonal imbalance, please consult your doctor immediately.

There is no evidence to suggest that long-term use of Ondansetron + Ranitidine can lead to dependency. It is important, however, to use this medicine strictly as prescribed by your doctor.

While natural remedies like ginger, peppermint oil, and certain yoga exercises can help manage mild nausea and vomiting, they may not be effective in managing severe symptoms related to chemotherapy, radiation therapy, or postoperative conditions. Always consult your doctor before starting any alternative therapies.

The form of the medicine depends on the manufacturer. If you need a specific type of capsule, such as a vegetarian one, please discuss it with your doctor or pharmacist.

Terms & Conditions


Available medicines for ONDANSETRON + RANITIDINE
R T Dom Injection 2 ML
R T Dom Injection 2 ML
Speciality Meditech Pvt Ltd
Pack of 2 ML
â‚ą11.48
MRP â‚ą14.00
18.00% OFF
Ranikul O Tablets 10
Ranikul O Tablets 10
Smart Laboratories Pvt Ltd
Pack of 10 Units
â‚ą20.80
MRP â‚ą40.00
48.00% OFF
Acidom O 4/150 MG Tablet 10
Acidom O 4/150 MG Tablet 10
Siesta Pharmaceuticals
Pack of 10 Units
â‚ą13.39
MRP â‚ą16.33
18.00% OFF
Doran O 2/50 MG Injection 2 ML
Doran O 2/50 MG Injection 2 ML
Bestochem Formulations (i) Ltd
Pack of 2 ML
â‚ą12.52
MRP â‚ą15.27
18.00% OFF
Anset R Injection 2ml
Anset R Injection 2ml
Bennet Mypher Pharmaceuticals Llp.ltd
Pack of 2 ML
â‚ą17.59
MRP â‚ą21.45
18.00% OFF
Ranidom On + Rantdn Injection 2 ML
Ranidom On + Rantdn Injection 2 ML
Mankind Pharmaceuticals Ltd.
Pack of 2 ML
â‚ą10.06
MRP â‚ą12.27
18.00% OFF
Reden O 2/150 MG Tablet 10
Reden O 2/150 MG Tablet 10
Medoz Pharma
Pack of 10 Units
â‚ą34.85
MRP â‚ą42.50
18.00% OFF
Aaro Plus Kit 2/25 MG Injection 1 ML
Aaro Plus Kit 2/25 MG Injection 1 ML
Dial Pharmaceuticals Pvt. Ltd.
Pack of 1 ML
â‚ą25.77
MRP â‚ą31.43
18.00% OFF

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