The main use of Phenobarbitone + Phenytoin is to control and manage certain types of seizures in people with epilepsy. It belongs to the group of anticonvulsant medicines.
Additionally, this combination of medications is also indicated for managing complex partial seizures, preventing and treating seizures that may occur during or after neurosurgery, and controlling seizures associated with status epilepticus.
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Phenobarbitone + Phenytoin is an anticonvulsant combination.
Phenobarbitone falls under the category of barbiturates. It enhances the effect of GABA, a brain neurotransmitter that inhibits nerve impulses. By boosting GABA's activity, Phenobarbitone makes neurons less excitable and increases the seizure threshold.
Phenytoin is a hydantoin anticonvulsant. It selectively blocks voltage-sensitive sodium channels in neurons and stabilises the threshold for electrical stimulation in the motor cortex during a seizure. This extends the effective refractory period and curtails repetitive firing of action potentials.
Together, these two components work to suppress the rapid firing of neurons in the central nervous system that instigates a seizure, effectively managing different types of seizures.
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Phenobarbitone + Phenytoin is available in the form of oral tablets for administration.
Phenobarbitone + Phenytoin combination is intended for use in adults and children. The starting dose for children is usually calculated based on their body weight.
Phenobarbitone + Phenytoin combination should not be used by patients with a known hypersensitivity to either phenobarbitone or phenytoin.
It is also contraindicated in patients with conditions such as porphyria and severe respiratory depression.
This combination can interact with cytochrome P450 inducers (e.g., rifampin, carbamazepine) and cytochrome P450 inhibitors (e.g., cimetidine, fluoxetine), and affect the effectiveness of oral contraceptives (e.g., ethinylestradiol, norethindrone), corticosteroids (e.g., hydrocortisone), cardiac glycosides (e.g., digoxin), tetracycline antibiotics (e.g., doxycycline), oral anticoagulants (e.g., rivaroxaban), and antiarrhythmics (e.g., quinidine).
Overdosing on Phenobarbitone + Phenytoin could lead to symptoms such as drowsiness, dizziness, nausea, and vomiting. In case of an overdose, seek immediate medical attention.
If a dose is missed, take it as soon as you remember. However, do not double the dose to make up for the missed one.
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening symptoms, please consult your doctor.
Drinking plenty of water can help manage side effects such as constipation.
Resting and avoiding strenuous activities can help manage fatigue and dizziness.
Phenobarbitone + Phenytoin may cause drowsiness and affect your ability to drive or operate heavy machinery. It is advisable to avoid these activities if you feel dizzy or sleepy after taking the medicine.
The use of Phenobarbitone + Phenytoin during pregnancy and lactation should be done under the guidance of a doctor due to potential risks to the baby.
Caution should be exercised while using Phenobarbitone + Phenytoin in patients with renal or hepatic impairment.
Elderly patients should also be careful while taking this medicine due to increased sensitivity to its effects.
It is advisable to maintain a healthy, balanced diet to support overall health while managing epilepsy.
Adequate sleep is recommended, as lack of sleep can trigger seizures.
Stress management techniques such as meditation and yoga can be beneficial in managing epilepsy.
Regular follow-ups with the doctor are necessary for monitoring the condition and adjusting the dosage if required.
Frequently asked questions
No, Phenobarbitone + Phenytoin is not a steroid. It is a combination of two anticonvulsant medications used to manage certain types of seizures.
Yes, it can be safe to take Phenobarbitone + Phenytoin daily as long as it is prescribed by your doctor.
The onset of action for Phenobarbitone + Phenytoin varies from person to person. Your doctor can provide more specific information based on your condition and dosage.
Phenobarbitone + Phenytoin can be taken at any time of the day, consistently, either with or without food, as advised by your doctor.
The duration of treatment with Phenobarbitone + Phenytoin is decided by your doctor based on your specific condition and response to the medication.
Phenobarbitone + Phenytoin is not available over the counter and requires a prescription from a doctor.
Yes, one of the common side effects of Phenobarbitone + Phenytoin can be drowsiness. Therefore, it may affect your sleep patterns.
Phenobarbitone + Phenytoin in other salts
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