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Pregabalin + Nortriptyline + Methylcobalamin

DRUGS FOR PERIPHERAL NEUROPATHY

Uses of Pregabalin + Nortriptyline + Methylcobalamin

  • Pregabalin + Nortriptyline + Methylcobalamin helps treat neuropathic pain, including conditions such as diabetic neuropathy, post-herpetic neuralgia, and fibromyalgia.
  • This combination of three medicines is used to alleviate chronic nerve pain associated with various neurological disorders by calming damaged or overactive nerves in the brain, which decreases the pain sensation. 
  • Additionally, it is effective in treating Vitamin B12 deficiency, often linked to nerve damage. 
  • Overall, it provides comprehensive pain relief and supports nerve health in individuals suffering from these conditions.

Side effects of Pregabalin + Nortriptyline + Methylcobalamin

The side effects of Pregabalin + Nortriptyline + Methylcobalamin are:

  • Constipation
  • Weight gain
  • Orthostatic
  • Hypotension
  • Increased heart rate
  • Dizziness
  • Sleepiness
  • Tiredness
  • Blurred vision
  • Dryness in mouth
  • Difficulty in urination
  • Uncoordinated body movements

How Pregabalin + Nortriptyline + Methylcobalamin works

  • Pregabalin binds to calcium channels in nerve cells, which helps reduce the release of neurotransmitters involved in transmitting pain signals. This action decreases the intensity of pain messages sent to the brain, making it effective in treating neuropathic pain.
  • Nortriptyline is a tricyclic antidepressant that works by inhibiting the reuptake of neurotransmitters such as serotonin and norepinephrine in the brain. By increasing the levels of these neurotransmitters, Nortriptyline helps modulate pain perception and improve mood, which can be particularly beneficial for those experiencing chronic pain.
  • Methylcobalamin, a form of Vitamin B12, is essential for maintaining nerve health. It plays a critical role in the regeneration and repair of damaged nerve cells, which helps restore normal nerve function and alleviates pain associated with nerve damage.

Certified content

Written By

docImg
Amit SharmaClinical Health & Medical Writer| 3 years

B. Pharm

Reviewed By

Amatul Ameen
Amatul Ameen Clinical Health & Medical Writer| 13 years

B. Pharm, MSc.

Expert Advice

Dosage Forms Available

  • Pregabalin + Nortriptyline + Methylcobalamin is taken orally (tablet).

Age and Dose Restrictions

  • This combination can be used for adults only. 

Contraindications

  • This medicine is contraindicated in patients with known allergies to methylcobalamin,  nortriptyline or pregabalin.

Other Medications to Avoid

  • Avoid taking other antidepressants, antihypertensives, antidiabetics (pioglitazone, rosiglitazone), any narcotic pain medicine (such as oxycodone), tranquillisers or medicines for anxiety (such as lorazepam), muscle relaxants, antiarrhythmic (quinidine), sedatives, selective serotonin reuptake inhibitors (SSRIs) (citalopram (Celexa), escitalopram) and antihistamines. The concomitant use may reduce the effectiveness of Methylcobalamin + Nortriptyline + Pregabalin.

Overdose and Missed Dose

  • If you take an excessive amount of Methylcobalamin + Nortriptyline + Pregabalin by accident, it is essential to take immediate medical attention from your doctor or nearby hospital. Symptoms of an overdose include drowsiness, confusional state, agitation, and restlessness. 
  • If you miss the dose, take it as soon as you remember. If the time for the next dosage is close, skip the missed one now and resume your regular dosage pattern. Do not double up the dose.

Management of Side Effects

  • Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening symptoms, please consult your doctor.

Use in Driving and Operating Machinery

  • This combination may cause dizziness and drowsiness and impair your ability to drive or operate machinery.

Use in Pregnancy and Lactation

  • This combination is not recommended during pregnancy. Caution is advised before using this combination during breastfeeding.

Caution in Other Conditions

  • Caution is advised in older adults and in patients with angioedema, kidney and heart failure, a bleeding problem or a low blood platelet count, diabetes, thyroid gland, and angle-closure glaucoma. 

Special Dietary and Lifestyle Recommendations

  • Keep your blood sugar levels within the target range for preventing and managing neuropathy.
  • Alcohol can cause further damage to nerves, so limit your alcohol consumption or avoid it.
  • Check your feet daily for wounds, cuts, or blisters, as neuropathy can reduce sensation and increase the risk of foot problems.
  • Follow your prescribed medication regimen consistently.  
  • Avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Nortriptyline may make your skin sensitive to sunlight.

Frequently asked questions

No, using this medicine during pregnancy may not be safe. Although there is a lack of information in human research, there is evidence from animal studies that this is harmful to a fetus. Your doctor will consider the risks and benefits before a prescription is given. Please consult your physician.

Within 2 to 4 hours, you must experience the benefit of this medicine.

No, it's likely unsafe to take this medication during breastfeeding. According to human data, the medicine may enter the breast milk and damage the unborn baby.

It is not recommended to use any antidepressants (like duloxetine, sertraline, and escitalopram), pain relievers (like codeine, hydrocodone, morphine, oxycodone, tramadol, and acetaminophen), and anti-seizure drugs (like topiramate), anti-anxiety medications (like alprazolam), sedative-hypnotic medications (like zolpidem), antihistamine medications (like diphenhydramine, cetirizine), muscle relaxant medications (like cyclobenzaprine), antiemetic medications (like ondansetron), and herbal medications to treat depression (like St. John's wort). Before using any prescription or over-the-counter medications, you must consult with your doctor.

Do not use Pregabalin + Nortriptyline + Methylcobalamin if you have an allergic reaction (hypersensitivity) to any of its components. Do not take this medicine if you consume alcohol. Due to a possible interaction, this medicine may increase the chance of serious adverse effects. We recommend that you consult a doctor as soon as possible.

No, please do not stop taking this medication without first consulting your doctor. There is a chance that symptoms may return if Pregabalin + Nortriptyline + Methylcobalamin is suddenly stopped.

Yes, this medication may lead to weight gain because it stimulates appetite. However, continuous movement and a diet that balances low-calorie foods with balanced meals may help you maintain your weight. If you continue to have issues maintaining a healthy weight, you must consult with a doctor.

No, the use of Pregabalin + Nortriptyline + Methylcobalamin will not lead to the development of any habitual actions. There have been no reports that withdrawal symptoms may appear when it is stopped. People in this situation can develop a psychological dependence on the medication if they continue to use it.

Yes, taking Pregabalin + Nortriptyline + Methylcobalamin frequently can cause dry mouth. If this side effect continues to disturb you, make an appointment with your doctor.

No, avoid consuming alcohol while taking Pregabalin + Nortriptyline + Methylcobalamin because it could increase dizziness and drowsiness.

No, this medication is unlikely to affect fertility in either men or women. However, there is currently insufficient evidence to justify any clear conclusion. Consult your doctor for the most accurate information.

Yes, Pregabalin + Nortriptyline + Methylcobalamin should be used with precaution, specifically if you have a history of kidney disorders or problems. Some patients may need a dosage modification. If you have any problems, you should consult your doctor.

Yes, it's likely safe to take this medication in liver disease patients. No modification to the dosage is recommended. If you have any problems, you should consult your doctor.

Yes, this medication may cause dizziness. While using this medication, it is recommended that you should not drive or operate heavy machinery. It is suggested to relax until you feel better if you are experiencing sleep or dizziness.

Terms & Conditions


Pregabalin + Nortriptyline + Methylcobalamin in other salts

ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE) + VITAMIN D3 (CHOLECALCIFEROL)ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEASCORBIC ACID + BIOTIN + CALCIUM PANTOTHENATE + FOLIC ACID + METHYLCOBALAMIN + NIACINAMIDE + RIBOFLAVIN + THIAMINE MONONITRATE + ZINC SULPHATEELEMENTAL CALCIUM + L-METHYLFOLATE CALCIUM + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATE + VITAMIN D3 (CHOLECALCIFEROL)METHYLCOBALAMIN + PREGABALINMETHYLCOBALAMINPREGABALINGABAPENTIN + NORTRIPTYLINEL METHYL FOLATE + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATEPREGABALIN + NORTRIPTYLINEGABAPENTIN + METHYLCOBALAMINDULOXETINE + PREGABALINALFACALCIDOL + DOCOSAHEXAENOIC ACID + EICOSAPENTAENOIC ACID + ELEMENTAL BORON + ELEMENTAL CALCIUM + FOLIC ACID + METHYLCOBALAMINMETHYLCOBALAMIN + THIOCTIC ACIDL METHYLFOLATE + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATEALPHA LIPOIC ACID + BENFOTIAMINE + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEBORON + CALCITRIOL/ CHOLECALCIFEROL + CALCIUM CARBONATE + DOCOSAHEXAENOIC ACID + EICOSAPENTAENOIC ACID + FOLIC ACID + METHYLCOBALAMINDHA + L-METHYLFOLATE + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEDOCOSAHEXAENOIC ACID + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEFOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + BENFOTIAMINE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + PREGABALIN + VITAMIN B6 / PYRIDOXINEDULOXETINE + METHYLCOBALAMINALPHA LIPOIC ACID + BENFOTIAMINE + ELEMENTAL CHROMIUM + INOSITOL + METHYLCOBALAMINDHA + L-METHYLFOLATE + METHYLCOBALAMINALPHA LIPOIC ACID + BENFOTIAMINE + INOSITOL + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEDOCOSAHEXAENOIC ACID + L METHYLFOLATE + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATEL-METHYLFOLATE + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + METHYLCOBALAMIN + PREGABALINALPHA LIPOIC ACID + GABAPENTIN + METHYLCOBALAMINBENFOTIAMINE + FOLIC ACID + METHYLCOBALAMIN + PREGABALIN + VITAMIN B6 / PYRIDOXINEFOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + BENFOTIAMINE + BIOTIN + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + THIAMINE MONONITRATE + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + METHYLCOBALAMINALPHA LIPOIC ACID + BIOTIN + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + BENFOTIAMINE + BIOTIN + ELEMENTAL CHROMIUM + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEMECOBALAMIN + PREGABALINALPHA LIPOIC ACID + CHROMIUM PICOLINATE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + SELENOMETHIONINE + ZINC MONOMETHIONINEALPHA LIPOIC ACID + BENFOTIAMINE + CHROMIUM PICOLINATE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINECYANOCOBALAMIN / VITAMIN B12 + PREGABALINALPHA LIPOIC ACID + BENFOTIAMINE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEFOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINE + VITAMIN D3 (CHOLECALCIFEROL)ALPHA LIPOIC ACID + BENFOTIAMINE + CHROMIUM POLYNICOTINATE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + SELENIUM DIOXIDEFOLIC ACID + METHYLCOBALAMINALPHA LIPOIC ACID + BENFOTIAMINE + BIOTIN + CHROMIUM PICOLINATE + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + CHROMIUM PICOLINATE + METHYLCOBALAMIN + OMEGA 3 FATTY ACID + SELENIUM DIOXIDEALPHA LIPOIC ACID + BENFOTIAMINE + CHROMIUM PICOLINATE + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + BENFOTIAMINE + CHROMIUM PICOLINATE + FOLIC ACID + METHYLCOBALAMIN + MYO INOSITOL + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + PREGABALIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINE + VITAMIN D3 (CHOLECALCIFEROL)DOCOSAHEXAENOIC ACID + L METHYLFOLATE + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATE + VITAMIN D3 (CHOLECALCIFEROL)FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE) + VITAMIN D3 (CHOLECALCIFEROL)CITICOLINE + METHYLCOBALAMINELEMENTAL IRON + ELEMENTAL ZINC + FOLIC ACID + METHYLCOBALAMINBORON + CALCITRIOL/ CHOLECALCIFEROL + CALCIUM CARBONATE + DHA / DOCOSAHEXAENOIC ACID + EPA / EICOSAPENTAENOIC ACID + FOLIC ACID + METHYLCOBALAMINALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + PYRIDOXINE HYDROCHLORIDE + THIAMINE MONONITRATEBENFOTIAMINE + FOLIC ACID + METHYLCOBALAMIN + PREGABALIN + VITAMIN B6 (PYRIDOXINE)AMITRIPTYLINE + PREGABALINCALCITRIOL/ CHOLECALCIFEROL + CALCIUM CARBONATE + L METHYLFOLATE + MAGNESIUM + METHYLCOBALAMIN + VITAMIN K27 + ZINCDHA / DOCOSAHEXAENOIC ACID + L METHYLFOLATE + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATE + VITAMIN D3 (CHOLECALCIFEROL)ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + PYRIDOXINE HYDROCHLORIDE + VITAMIN D3 (CHOLECALCIFEROL)ELEMENTAL IRON + FOLIC ACID + METHYLCOBALAMINCAPSAICIN + DICLOFENAC DIETHYLAMINE + MENTHOL + METHYL SALICYLATE + PREGABALINMETHYLCOBALAMIN + NICOTINAMIDE + VITAMIN B6 / PYRIDOXINEFOLIC ACID + METHYLCOBALAMIN + NIACINAMIDE + VITAMIN C / ASCORBIC ACIDD-PANTHENOL + METHYLCOBALAMIN + NIACINAMIDE + VITAMIN B6 / PYRIDOXINEFOLIC ACID + METHYLCOBALAMIN + NIACINAMIDEMETHYLCOBALAMIN + NIACINAMIDE + VITAMIN B6 / PYRIDOXINEFOLIC ACID + METHYLCOBALAMIN + NIACINAMIDE + VITAMIN B6 / PYRIDOXINEMETHYLCOBALAMIN + NICOTINAMIDE + VITAMIN B6 (PYRIDOXINE)D-PANTHENOL + METHYLCOBALAMIN + NIACINAMIDE + VITAMIN B6 (PYRIDOXINE)FERROUS ASCORBATE + FOLIC ACID + METHYLCOBALAMINACECLOFENAC + PREGABALINEPALRESTAT + METHYLCOBALAMINEPALRESTAT + PREGABALINAMITRIPTYLINE + METHYLCOBALAMINFOLIC ACID + L-CARNITINE / LEVOCARNITINE + METHYLCOBALAMINMETFORMIN + METHYLCOBALAMINCALCIUM-5 METHYLTETRAHYDROFOLATE + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATEALPHA LIPOIC ACID + BENFOTIAMINE + CALCIUM CARBONATE + CHROMIUM PICOLINATE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINE + VITAMIN D3 (CHOLECALCIFEROL)NORTRIPTYLINED CHIRO INOSITOL + L-METHYLFOLATE + METFORMIN + METHYLCOBALAMIN + MYO INOSITOLFOLIC ACID + METHYLCOBALAMIN + PREGABALIN + VITAMIN B6 / PYRIDOXINEL-METHYLFOLATE CALCIUM + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATEMECOBALAMIN + NORTRIPTYLINE + PREGABALINFERROUS BISGLYCINATE + FOLIC ACID + METHYLCOBALAMIN + ZINC BISGLYCINATEFOLIC ACID + METHYLCOBALAMIN + PYRIDOXINE HYDROCHLORIDECYANOCOBALAMIN / VITAMIN B12 + NORTRIPTYLINE + PREGABALINADENOSYLCOBALAMIN + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B1 + VITAMIN B2 + VITAMIN B6 (PYRIDOXINE)ETORICOXIB + PREGABALINDIACEREIN + GLUCOSAMINE SULFATE POTASSIUM CHLORIDE + METHYL SULFONYL METHANE + METHYLCOBALAMINBORON + CALCITRIOL/ CHOLECALCIFEROL + CALCIUM CARBONATE + FOLIC ACID + METHYLCOBALAMIN + OMEGA 3 FATTY ACIDALPHA LIPOIC ACID + BENFOTIAMINE + CALCIUM CARBONATE + CHROMIUM PICOLINATE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + PYRIDOXINE HYDROCHLORIDE + VITAMIN D3 (CHOLECALCIFEROL)ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + THIAMINE + VITAMIN B6 / PYRIDOXINE
Available medicines for PREGABALIN + NORTRIPTYLINE + METHYLCOBALAMIN
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