Rasburicase

Dosage Forms Available

• Rasburicase is available in the form of a sterile, lyophilized powder which needs to be reconstituted before use.

• Once reconstituted, it is administered through an intravenous infusion route.

Age and Dose Restrictions

• This medicine is approved for use in both adults and children. The specific age at which it can be administered is not restricted, making it suitable across a broad age range.

Contraindications

• Rasburicase is contraindicated in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency.

• It is also contraindicated for patients with a history of severe allergic or hypersensitivity reactions to the medication or any of its components.

Other Medications to Avoid

• This medicine may interact with other medications such as xanthine oxidase inhibitors (such as allopurinol), anticoagulants (like warfarin), and certain types of chemotherapeutic agents (such as cyclophosphamide).

• It is crucial to consult a doctor before starting or stopping any other medications while using Rasburicase.

Overdose and Missed Dose

• An overdose of Rasburicase may lead to severe side effects such as abnormal breakdown of red blood cells (hemolysis) or elevated levels of methaemoglobin (methaemoglobinaemia). It is important to seek immediate medical attention if an overdose is suspected.

• If a dose of Rasburicase is missed, it should be administered as soon as possible. However, if it is nearly time for the next scheduled dose, the missed dose should be skipped to avoid potential overdose.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• To manage nausea, try taking the medication with a small amount of food or water.

• If experiencing headaches, ensure adequate hydration and rest.

Use in Driving and Operating Machinery

• Rasburicase generally does not affect your ability to drive or operate machinery. However, individual responses can vary, and it is important to know how you react to this medicine before engaging in such activities.

Use in Pregnancy and Lactation

• The safety of Rasburicase during pregnancy and lactation has not been fully established.

• It is recommended that pregnant or breastfeeding women consult their doctor before using this medication.

Caution in Other Conditions

• Patients with kidney issues need to use Rasburicase with caution due to its effects on uric acid levels and potential kidney stress.

• Patients already suffering from liver conditions should discuss their health with their doctor before starting treatment with Rasburicase, to avoid any potential complications.

Special Dietary and Lifestyle Recommendations

• Maintain hydration by drinking plenty of fluids. This assists in preventing kidney stones and supports the kidneys in filtering out waste products efficiently.

• A diet low in purines may be beneficial as it helps decrease uric acid production. Foods high in purines include red meats, organ meats, and some seafood.

• Engaging in regular light exercise can help maintain joint mobility and general health without overexerting the kidneys.