Rebamipide
Uses of Rebamipide
Rebamipide is primarily used for the management of gastric ulcers and gastritis. It falls under the classification of gastroprotective medications.
Secondary uses of Rebamipide include the management of duodenal ulcers, the prevention of NSAID-induced ulcers, and the treatment of chronic gastritis. Off-label and investigational uses also include treatment of dry eye and Sjögren's syndrome, oral ulcers and stomatitis, chemotherapy-induced mucositis, and inflammatory bowel diseases, like ulcerative colitis.
Side effects of Rebamipide
Diarrhoea
Nausea
Vomiting
Abdominal Pain
Rash
How Rebamipide works
Rebamipide is a gastroprotective medicine.
It helps protect the stomach by increasing mucus, reducing inflammation, and healing ulcers. It also helps fight damage from harmful substances and promotes new blood vessel growth for better healing.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
- Rebamipide is available for use via the oral route in the form of tablets.
Age and Dose Restrictions
- Rebamipide is meant for adult use only. It is not recommended for use in children as its safety and efficacy have not been established in this age group.
Contraindications
- Rebamipide is contraindicated in patients with a known hypersensitivity to the medication or any of its components.
Other Medications to Avoid
- Rebamipide may interact with Proton pump inhibitors (such as omeprazole lansoprazole), which may decrease its efficacy by reducing gastric prostaglandin production.
Overdose and Missed Dose
- An overdose of Rebamipide may cause gastrointestinal symptoms, such as diarrhoea, constipation, nausea, vomiting, and abdominal pain. If you suspect an overdose, inform your doctor and follow the advice accordingly.
- If you miss a dose of Rebamipide, take it as soon as you remember. However, if it is near the time of your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for a missed one.
Management of Side Effects
Most side effects of Rebamipide are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
- Drinking plenty of water can help manage gastrointestinal side effects such as nausea and constipation.
- Taking the medication with or after food may reduce gastrointestinal side effects.
Use in Driving and Operating Machinery
- Rebamipide does not usually affect your ability to drive or operate machinery. However, if you experience side effects such as dizziness or headache after taking this medication, avoid such activities until you feel better.
Use in Pregnancy and Lactation
- Rebamipide should be used during pregnancy and lactation only if the potential benefits justify the potential risks to the fetus or infant. Women who are pregnant or breastfeeding should consult their doctor before using this medicine.
Caution in Other Conditions
- Patients with severe renal or hepatic dysfunction should be cautious while taking Rebamipide as it may increase concentrations of the medicine in the body.
- Patients with gastric ulcers should consult their doctor before starting Rebamipide.
Special Dietary and Lifestyle Recommendations
- Maintaining a balanced diet can help manage gastric ulcers and chronic gastritis conditions for which Rebamipide is indicated.
- Regular consumption of fruits and vegetables can help promote a healthy gut.
- Avoiding spicy, fried, and fatty foods can reduce gastric discomfort associated with these conditions.
- Limiting alcohol and caffeine intake can help prevent further irritation of the stomach lining.
- Quitting smoking can improve overall gastric health as it reduces acid production in the stomach.
Frequently asked questions
Is Rebamipide a gastro-protective medication?
Yes, Rebamipide is a gastro-protective medication. It is used to manage and prevent gastric ulcers and gastritis.
Does Rebamipide impact metabolism or weight gain?
There is no scientific evidence indicating that Rebamipide directly impacts metabolism or causes weight gain. However, any changes in weight or metabolic abnormalities should be discussed with your doctor.
Can Rebamipide be used as an anti-inflammatory medicine?
Rebamipide has gastro-protective effects that include inhibiting inflammatory cytokines like TNF-alpha and IL-8 that are involved in gastric inflammation and ulceration. However, it is not typically used as a general anti-inflammatory medicine.
Does Rebamipide cause drowsiness or affect alertness?
Rebamipide may cause dizziness in some patients. If you experience dizziness while taking this medicine, you should avoid driving or operating machinery until the effect subsides.
Can I take Rebamipide without food?
Rebamipide should be taken orally with a glass of water after meals to ensure the best absorption and effectiveness.
How long does it take for Rebamipide to start working?
Rebamipide is absorbed in the small intestine and reaches peak blood concentrations within 1-2 hours of oral administration, thus starting its action during this period.
Will stopping Rebamipide suddenly cause any problems?
Abruptly stopping any medication can possibly lead to withdrawal symptoms or a relapse of the condition it was managing. Therefore, if you need to stop taking Rebamipide, discuss this with your doctor, who will guide you on how to safely discontinue the medicine.
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