Reteplase

Dosage Forms Available

• Reteplase is available as a sterile powder for reconstitution and is administered intravenously (injection).

Age and Dose Restrictions

• This medicine is exclusively meant for adults of age above 18 years.

Contraindications

• Reteplase is contraindicated in patients having active internal bleeding, recent history of cerebrovascular accident, intracranial or intraspinal surgery or trauma within 2 months, presence of intracranial neoplasm, arteriovenous malformation, or aneurysm, known bleeding diathesis, and severe uncontrolled hypertension.

Other Medications to Avoid

• Reteplase can interact with anticoagulants (such as heparin and warfarin), antiplatelet agents (like aspirin and clopidogrel), and other medicines affecting coagulation (such as thrombin inhibitors like lepirudin).

Overdose and Missed Dose

• An overdose of Reteplase might result in severe bleeding complications. In such cases, immediate medical attention is necessary.

• If a prescribed dose of Reteplase is missed during the treatment course, it should be administered as soon as possible. However, it should be noted that no more than two doses should be used to manage a single myocardial infarction.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• Drinking plenty of fluids and resting may help manage nausea and vomiting.

• Sitting or lying down can help manage episodes of hypotension.

Use in Driving and Operating Machinery

• Reteplase may not directly affect the ability to drive or operate heavy machinery. However, some side effects like dizziness or fatigue may impair these abilities. Avoid driving or operating machinery if you experience such symptoms.

Use in Pregnancy and Lactation

• It is advised to consult a doctor before using this medicine during pregnancy and lactation.

Caution in Other Conditions

• Patients with recent major surgery, obstetrical delivery, organ biopsy, recent trauma, or cardiopulmonary resuscitation should exercise caution when administering Reteplase.

Special Dietary and Lifestyle Recommendations

• A balanced diet rich in fruits and vegetables and low in saturated fats can help manage heart health.

• Regular physical activity under the guidance of a trained professional helps maintain cardiovascular health.

• Regular monitoring of blood pressure and cholesterol levels is recommended.