Rifampicin

Dosage Forms Available

• Rifampicin is available in oral form (capsule) and administered intravenously (injection).

Age and Dose Restrictions

• Rifampicin is generally prescribed for adults. In children, it is prescribed by the doctor as per the child's weight.

Contraindications

• This medicine is contraindicated for individuals who have a known allergy to Rifampicin. It should be avoided in patients with jaundice or a history of Rifampicin-induced jaundice.

Other Medications to Avoid

• Rifampicin can interact with cytochrome P450 inducers (such as phenytoin, and phenobarbital), antacids and H2 blockers (like ranitidine and omeprazole), anticoagulants (like warfarin), antidiabetic agents (such as metformin, glipizide), and antiretroviral medicines (like ritonavir, efavirenz).

Overdose and Missed Dose

• An overdose of Rifampicin may lead to symptoms such as nausea, vomiting, abdominal pain, pruritus, headache, and orange-red discolouration of skin and body fluids. In such cases, consult a doctor immediately.

• If you miss a dose of Rifampicin, it should be taken as soon as you remember. However, avoid doubling the dose to catch up.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• Nausea and vomiting can be managed by taking Rifampicin with food.

• Drinking plenty of water may help alleviate abdominal pain.

• Diarrhoea can be managed by staying hydrated and consuming a diet high in fibre.

Use in Driving and Operating Machinery

• Rifampicin may cause dizziness or drowsiness. Therefore, caution is advised while driving or operating heavy machinery after taking this medication.

Use in Pregnancy and Lactation

• The use of Rifampicin during pregnancy should be done only if the benefits outweigh the risks, as it may increase the risk of maternal and neonatal bleeding.

• Because of the potential for tumorigenicity shown for this medication in animal studies, a decision should be made whether to discontinue nursing or discontinue the medication.

Caution in Other Conditions

• Patients who have pre-existing liver or kidney disease should exercise caution when taking Rifampicin as the dosage may need to be adjusted.

• Caution is also recommended for patients with porphyria as Rifampicin may precipitate acute attacks.

Special Dietary and Lifestyle Recommendations

• Regular monitoring of liver function tests is advisable to prevent hepatotoxicity.

• Consuming a healthy diet rich in essential nutrients can support overall health while under treatment.

• Adequate hydration is critical to prevent any dehydration from diarrhoea side effects.