Selexipag

Dosage Forms Available

• This medicine is available for oral use in the form of tablets.

Age and Dose Restrictions

• This medicine is meant for use by adults only.

Contraindications

• This medicine is contraindicated in patients with severe hepatic impairment (Child-Pugh class C).

Other Medications to Avoid

• This medicine may interact with strong inhibitors of CYP2C8 (such as gemfibrozil) and moderate inhibitors of CYP2C8 (such as clopidogrel).

Overdose and Missed Dose

• In case of an overdose, supportive measures should be taken as required, as there is no specific antidote. Dialysis is unlikely to be effective owing to the high plasma protein binding of Selexipag and its metabolite.

• If a dose is missed, it should be taken as soon as you remember. However, skip the missed dose if it is almost time for your next scheduled dose. Do not take an extra dose to make up for the missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• To manage headaches, consider adjusting the timing of your medication or increasing water intake.

• For nausea or diarrhoea, it may help to take Selexipag with food and increase fluid intake, respectively.

Use in Driving and Operating Machinery

• Selexipag may cause side effects like headache or flushing which could affect your ability to drive or operate heavy machinery. You should be cautious about driving or operating machinery until you know how this medicine affects you.

Use in Pregnancy and Lactation

• The effects of Selexipag during pregnancy and lactation have not been sufficiently studied. Therefore, it is recommended to consult your doctor regarding its use if you are pregnant or breastfeeding.

Caution in Other Conditions

• Patients with severe renal impairment should also exercise caution when using this medicine.

Special Dietary and Lifestyle Recommendations

• Maintain a balanced diet rich in high-fibre foods, which can help manage potential gastrointestinal side effects like nausea or diarrhoea associated with Selexipag usage.

• Regular physical activity can help improve cardiovascular health. Consult your doctor about suitable exercises that you can perform safely.

• Avoid smoking and limit alcohol consumption as these can worsen symptoms of PAH.