Silymarin
DRUGS FOR LIVER DISEASEUses of Silymarin
- Silymarin is used in the treatment of chronic liver diseases and liver cirrhosis.
- It is a herbal supplement derived from milk thistle that helps protect liver cells from damage, supports liver regeneration, and has antioxidant and anti-inflammatory properties, making it beneficial in managing various liver conditions.
Side effects of Silymarin
- Abdominal fullness
- Bloating
- Flatulence
- Abdominal pain
- Anorexia (lack of appetite)
- Nausea
- Diarrhoea
- Headache
- Pruritus (generalised itching)
How Silymarin works
Silymarin is a hepato-protectant with an antioxidant effect that reduces damage from free radicals and regulates the content of glutathione, an important protective molecule against reactive oxygen species. It stabilises the cell membrane, which helps block toxic substances from entering the liver cells and causing damage. It helps promote RNA synthesis, helps regenerate damaged liver cells, and prevents a decrease in liver function, which can occur due to liver fibrosis.
Certified content
Written By
B. Pharm
Reviewed By
B. Pharm, MSc.
Expert Advice
Dosage Forms Available
- Silymarin can be taken orally (tablet and suspension).
Age and Dose Restrictions
- It is not intended to be used by children.
Contraindications
- It is contraindicated in patients with a history of hypersensitivity to Silymarin. It is also contraindicated in patients with hormonal disorders like uterine, breast, and ovarian cancer.
Other Medications To Avoid With This Medicine
- Avoid taking analgesics & antipyretics (paracetamol), lipid-lowering medications (atorvastatin), anticonvulsatns (phenytoin), antipsychotics (risperidone), blood thinners (warfarin), anti-allergy medications (allegra), and anti-anxiety medications (alprazolam). These medications may alter the safety and effectiveness of Silymarin.
Overdose and Missed Dose
- In case of accidental overdose if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
- If you miss a dose of Silymarin, take it as soon as you remember. But, if the next dose is near, skip the missed dose and resume the regular dosing regime.
Use In Driving And Operating Machinery
- The impact of this medication on driving is uncertain. Should you experience any symptoms, please seek advice from your doctor.
Use in Pregnancy and Lactation
- This medication is not recommended during pregnancy and breastfeeding.
Caution In Other Conditions
- Caution is advised in elderly patients with any other pre-existing diseases.
Special Dietary & Lifestyle Recommendation
- Avoid taking painkillers in excess if you have been diagnosed with liver disease or liver damage as these medicines can cause further damage to the liver.
- Avoid alcohol consumption.
- Get your liver function test done routinely on the advice of your doctor to monitor liver enzyme levels.
Frequently asked questions
Can Silymarin cure fatty liver?
It can help in fatty liver to some extent as it helps in the regeneration of liver cells.
When is the best time to take Silymarin?
Take it as directed by your doctor. It is best to take it after meals to avoid abdominal discomfort.
Does Silymarin cause gas?
Yes. stomach upset, gas and flatulence are the common side effects seen with the use of this medication.
Who should not take Silymarin?
It should not be taken by children under 18 years of age,
Is Silymarin good for the heart?
It is mainly given for its liver protective effect. However, some studies have shown its benefit in heart conditions, but it has not been approved for the same.
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