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Silymarin + Ursodeoxycholic Acid

Uses of Silymarin + Ursodeoxycholic Acid

  • Silymarin + Ursodeoxycholic Acid is primarily used for managing various liver disorders. This medicine belongs to the class of hepatoprotective and gallstone dissolution agents.

  • It is also indicated for conditions such as acute and chronic viral hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease (NAFLD), cirrhosis, primary biliary cholangitis (PBC), gallstones, and Amanita mushroom poisoning.

Side effects of Silymarin + Ursodeoxycholic Acid

  • Nausea

  • Diarrhoea

  • Abdominal discomfort

  • Headache

  • Skin rash or pruritus

How Silymarin + Ursodeoxycholic Acid works

  • Silymarin is a polyphenolic flavonoid derived from milk thistle seeds. It acts as an antioxidant, neutralising harmful substances known as free radicals. Additionally, it stabilises cell membranes and regulates their permeability, helping to protect liver cells.

  • Ursodeoxycholic Acid is a naturally occurring bile acid. It reduces cholesterol absorption in the intestine and decreases cholesterol secretion into bile, which can help dissolve cholesterol gallstones.

  • Together, these components work synergistically to protect the liver cells, reduce inflammation, and improve bile flow, thereby managing various liver diseases effectively.

Certified content

Written By

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Dr. Osama AhmedDental/Medical Writer, Editor, Reviewer| 2 years

Bachelor of Dental Surgery

Reviewed By

Dr. Michelle Frank
Dr. Michelle FrankMedical Content Writer| 8 years

Doctor of Medicine

Expert Advice

Dosage forms available

  • Silymarin + Ursodeoxycholic Acid is available as tablets and capsules to be taken orally.

Age and dose restrictions

  • This medication is intended for use in adults and children over the age of 12 years.

Contraindications

  • Silymarin + Ursodeoxycholic Acid is contraindicated in patients with known allergies to silymarin or Ursodeoxycholic acid.

  • It should not be used in patients with bile duct obstruction or intestinal disorders that impair absorption.

Other medications to avoid

  • This combination may interact with cytochrome P450 enzyme system metabolisers anti-arrhythmic medication (such as amiodarone), anti-ulcer medication (such as cimetidine), bile acid sequestrants (such as cholestyramine and colestipol) and antidiabetic agents (such as insulin and metformin).

Overdose and missed dose

  • Overdose of this combination can lead to symptoms such as severe stomach pain, nausea, vomiting, and jaundice. If you suspect an overdose, seek immediate medical attention.

  • If you miss a dose of this medicine, take it as soon as you remember. However, if it's nearing the time of your next dose, skip the missed one and continue with your regular dosing schedule. Do not double up on the doses.

Management of side effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • Drinking plenty of water may help manage any gastrointestinal symptoms, such as nausea or diarrhoea.

  • Taking the medication with food can help minimise stomach discomfort.

Use in driving and operating machinery

  • This medication does not usually affect your ability to drive or operate heavy machinery. However, if you experience side effects such as dizziness or fatigue, avoid these activities.

Use in pregnancy and lactation

  • It is advisable to consult your doctor before using Silymarin + Ursodeoxycholic Acid during pregnancy or breastfeeding.

Caution in other conditions

  • Patients with gallbladder disease or those with severe liver disease should take caution while using this medicine.

Special dietary and lifestyle recommendations

  • Maintain a balanced diet, low in saturated fats and high in fruits, vegetables and whole grains, to support overall liver health.

  • Moderate exercise can help maintain a healthy weight and improve liver function.

  • Avoid the use of illegal substances and unnecessary medications as they can potentially damage the liver.

Frequently asked questions

No, Silymarin and Ursodeoxycholic Acid are not steroids. Silymarin is a liver-protective antioxidant and Ursodeoxycholic Acid helps with liver function.

Silymarin + Ursodeoxycholic Acid is not associated with affecting sleep. However, if you have concerns about how this medication might affect your sleep patterns or overall sleep quality, you should consult your doctor for advice.

Silymarin + Ursodeoxycholic Acid is not directly associated with affecting fertility. If you are planning to conceive and are concerned about how taking this medication might impact your fertility, it would be wise to discuss this with your doctor.

Yes, it is generally safe to take Silymarin + Ursodeoxycholic Acid daily as directed by your physician. The dosage and frequency of administration will be based on your specific condition and how you respond to treatment.

The exact time Silymarin + Ursodeoxycholic Acid takes to work can vary depending on individual patient factors and the specific disorder being managed. Your doctor can provide more personalised information based on your health condition and response to treatment.

Silymarin + Ursodeoxycholic Acid is usually a prescription medication and may not be available over the counter. Always consult your doctor before starting any new medication.

The best time to take Silymarin + Ursodeoxycholic Acid is usually decided by your doctor, according to your health condition and response to treatment.

Terms & Conditions


Available medicines for SILYMARIN + URSODEOXYCHOLIC ACID
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