Tenecteplase

Dosage Forms Available

• Tenecteplase is available for use via the intravenous route in the form of a sterile, white-to-off-white lyophilized powder.

Age and Dose Restrictions

• This medicine is meant for adults aged 18 and above.

Contraindications

• Tenecteplase is contraindicated in patients with known structural cerebral vascular lesions or arteriovenous malformations. It is also contraindicated in patients with active bleeding or bleeding diathesis, excluding menses. Significant head trauma or prior stroke within the past 3 months are also contraindications for the use of Tenecteplase.

Other Medications to Avoid

• Tenecteplase may interact with anticoagulants (such as heparin and warfarin) and antiplatelet agents (such as clopidogrel).

Overdose and Missed Dose

• An overdose of Tenecteplase may lead to severe bleeding complications, including intracranial, gastrointestinal, retroperitoneal bleeding, and excessive bleeding at the injection site. If you suspect an overdose, contact your doctor immediately.

• If you forget a dose of this medicine, consult your doctor immediately. As Tenecteplase is typically administered in emergency situations under medical supervision, missing a dose is unlikely.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor. Some tips include:

• Drinking plenty of fluids may help manage side effects like nausea and vomiting.

• Try to rest and relax if you experience hypotension, as stress can worsen this condition.

Use in Driving and Operating Machinery

• As Tenecteplase may cause side effects such as hypotension, which can impact your ability to concentrate, it is advised not to drive or operate heavy machinery until you know how this medicine affects you.

Use in Pregnancy and Lactation

• Tenecteplase should be used during pregnancy only if the potential benefit justifies the potential risk to the foetus. Caution should be exercised when this medicine is administered to a nursing woman.

Caution in Other Conditions

• Patients with a history of stroke or intracranial haemorrhage, active internal bleeding, acute pericarditis or subacute bacterial endocarditis, and hemostatic defects, including those secondary to severe hepatic or renal disease, should also exercise caution when taking Tenecteplase.

Special Dietary and Lifestyle Recommendations

• Limit your intake of saturated fats, trans fats, sodium (salt), and added sugars.

• Monitor your blood pressure regularly if you have been diagnosed with hypertension.