Tibolone
Uses of Tibolone
Tibolone is used mainly for managing menopausal symptoms in postmenopausal women and belongs to the class of synthetic steroid medications.
It is also useful in preventing osteoporosis in postmenopausal women who are at high risk of fractures.
Side effects of Tibolone
Abdominal pain and discomfort
Vaginal bleeding or spotting
Breast tenderness or pain
Weight gain
Depression
How Tibolone works
Tibolone is a synthetic steroid medication used in hormone replacement therapy.
It acts as a prodrug that is metabolized into compounds that mimic the effects of estrogen, progesterone, and testosterone. This results in the alleviation of menopausal symptoms such as hot flashes and vaginal dryness, and also helps in maintaining bone density.
Certified content
Written By
BDS, MDS
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Tibolone is available for use as oral tablets.
Age and Dose Restrictions
This medicine is meant for adult women, specifically postmenopausal women.
Contraindications
This medicine is contraindicated in women with unexplained vaginal bleeding, active history of venous thromboembolism, active or recent thromboembolic disease (e.g., angina, myocardial infarction), liver disease or liver function test abnormalities, known or suspected oestrogen-dependent malignant tumours, and porphyria.
Other Medications to Avoid
Tibolone can interact with anticonvulsants (such as phenytoin and carbamazepine), antimicrobials (like rifampicin and griseofulvin), antiretrovirals (including ritonavir and nelfinavir), and herbal supplements containing St. John's wort.
Overdose and Missed Dose
An overdose of Tibolone may lead to symptoms such as nausea, dizziness, and vaginal bleeding. If these symptoms occur, it is important to seek medical advice immediately.
If you miss a dose of Tibolone, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a forgotten tablet.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening symptoms, please consult your doctor.
If experiencing nausea, try taking the medicine with food or a glass of milk.
For headaches or dizziness, it may help to take the medicine at bedtime.
Use in Driving and Operating Machinery
Tibolone may cause dizziness or blurred vision. It is advised to avoid driving or operating heavy machinery until you know how Tibolone affects you.
Use in Pregnancy and Lactation
Tibolone is contraindicated during pregnancy and while breastfeeding. It can harm the developing baby.
If you are planning to become pregnant or are breastfeeding, consult your doctor before starting Tibolone.
Caution in Other Conditions
Women with liver disease should exercise caution when using Tibolone due to its extensive metabolism in the liver.
Caution should also be exercised in women with a history of thromboembolic disorders due to an increased risk of blood clots.
Special Dietary and Lifestyle Recommendations
A diet rich in calcium and vitamin D is recommended to help manage bone health in menopause. Foods such as dairy products, green leafy vegetables, and fish can be beneficial.
Regular weight-bearing exercise like walking or jogging can help maintain bone density.
Smoking cessation is strongly advised as smoking can accelerate bone loss.
Limiting alcohol intake can also reduce the risk of osteoporosis.
Ensure adequate hydration by drinking plenty of water throughout the day.
Frequently asked questions
Can Tibolone be taken by pre-menopausal women?
No, Tibolone is specifically designed for postmenopausal women experiencing symptoms of menopause. It should not be taken by pre-menopausal women or those who are still having periods.
Does Tibolone have any effect on my mood?
Tibolone may have some effects on mood due to its hormone-like actions. Some women report feeling more balanced and less prone to mood swings while taking it. However, depression is also listed as a possible side effect.
How long does it take for Tibolone to start working?
The time for Tibolone to show its effects varies among individuals. Some may experience relief from menopausal symptoms within a few weeks, while others may need to take it for up to three months before they notice a significant improvement.
Can I take Tibolone if I am at risk of developing breast cancer?
Tibolone may not be suitable for those at high risk of developing breast cancer. Always discuss your medical history and potential risks with your doctor before starting any new medication.
Does Tibolone interact with any foods?
While there is no specific dietary restriction while taking Tibolone, grapefruit juice may increase the side effects of this medicine by slowing down its breakdown in the body.
Is Tibolone available over the counter, or do I need a prescription?
Tibolone is not available over the counter and requires a doctor's prescription.
What precautions should I take while using Tibolone?
You should inform your doctor about any medical conditions you have, particularly liver or kidney disease, history of thromboembolic disorders, endometrial hyperplasia, uterine fibroids, epilepsy, migraine, diabetes, hypertension, cholelithiasis, and otosclerosis before starting treatment with Tibolone.
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